{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T23:40:01Z","timestamp":1749944401856,"version":"3.41.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>There has been a 5-fold increase in the number of cases of hepatitis C virus (HCV) infection among pregnant women, which is potentially associated with the increase in opioid use.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This study was a retrospective review of infants born at a tertiary urban hospital in New Jersey, from January 1, 2011 to January 1, 2021, who were born to mothers with a prenatal diagnosis of HCV.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Of the 142 mothers with a prenatal diagnosis of HCV, 114 (80%) infants had a diagnosis of HCV exposure in the electronic health records. Of the HCV-exposed infants with follow-up data at 24 months of age, 52 (46%) were tested, with 34 of 52 (65%) receiving adequate testing. Infants documented as HCV exposed were more likely to be born to a mother with nonopioid drug use in pregnancy (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01) and have a higher birth weight (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.03). Of tested infants, those with a higher number of well-child pediatrician visits (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01) were more likely to receive adequate testing. Trends showed more polymerase chain reaction testing than antibody testing for those who were inadequately tested.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>A significant proportion of infants born to HCV-infected mothers were either not identified at birth (20%) or did not receive adequate testing on follow-up (35%). Further work needs to be done to improve documentation of HCV exposure at birth and follow-up testing to avoid missing congenitally acquired HCV.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/inf.0000000000004355","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T20:00:34Z","timestamp":1713211234000},"page":"803-808","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Hepatitis C Exposure Diagnosis and Testing in Infants Born to Hepatitis C Virus-infected Mothers"],"prefix":"10.1097","volume":"43","author":[{"given":"Natalie","family":"Morris","sequence":"first","affiliation":[{"name":"From the Cooper Medical School of Rowan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystal","family":"Hunter","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Cooper Children\u2019s Regional Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwanath","family":"Bhat","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Cooper University Hospital, Camden, New Jersey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla","family":"Kushnir","sequence":"additional","affiliation":[{"name":"From the Cooper Medical School of Rowan University"},{"name":"Division of Neonatology, Department of Pediatrics, Cooper Children\u2019s Regional Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"R1-20250614","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2105\/AJPH.2017.304132","article-title":"Increases in acute hepatitis C virus infection related to a growing opioid epidemic and associated injection drug use, United States, 2004 to 2014.","volume":"108","author":"Zibbell","year":"2018","journal-title":"Am J Public Health"},{"key":"R3-20250614","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s10620-019-05511-y","article-title":"New face of hepatitis C.","volume":"64","author":"Wu","year":"2019","journal-title":"Dig Dis Sci"},{"key":"R5-20250614","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/cid\/ciw026","article-title":"Failure to test and identify perinatally infected children born to hepatitis C virus-infected women.","volume":"62","author":"Kuncio","year":"2016","journal-title":"Clin Infect Dis"},{"key":"R7-20250614","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/cid\/ciu447","article-title":"Vertical transmission of hepatitis C virus: systematic review and meta-analysis.","volume":"59","author":"Benova","year":"2014","journal-title":"Clin Infect Dis"},{"key":"R9-20250614","first-page":"35","article-title":"Infants, children born to HCV-infected moms need to be tested, followed up.","volume":"34","author":"Abughali","year":"2013","journal-title":"Am Acad Pediatr"},{"key":"R10-20250614","doi-asserted-by":"crossref","first-page":"e20192482","DOI":"10.1542\/peds.2019-2482","article-title":"Hepatitis C testing among perinatally exposed infants.","volume":"145","author":"Lopata","year":"2020","journal-title":"Pediatrics"},{"key":"R12-20250614","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/MPG.0b013e318258328d","article-title":"NASPGHAN practice guidelines: diagnosis and management of hepatitis C infection in infants, children, and adolescents.","volume":"54","author":"Mack","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"R13-20250614","doi-asserted-by":"crossref","first-page":"ofz448","DOI":"10.1093\/ofid\/ofz448","article-title":"Addressing the disease burden of vertically acquired hepatitis C virus infection among opioid-exposed infants.","volume":"6","author":"Protopapas","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"R16-20250614","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10995-015-1845-4","article-title":"Pediatric return appointment adherence for child welfare-involved children in Los Angeles California.","volume":"20","author":"Schneiderman","year":"2016","journal-title":"Matern Child Health J"},{"key":"R17-20250614","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2017.07.039","article-title":"Hepatitis C in pregnancy: screening, treatment, and management.","volume":"217","author":"Hughes","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"R18-20250614","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7204a1","article-title":"CDC recommendations for hepatitis C testing among perinatally exposed infants and children - United States, 2023.","volume":"72","author":"Panagiotakopoulos","year":"2023","journal-title":"MMWR Recomm Rep"}],"container-title":["Pediatric Infectious Disease Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000004355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T23:05:54Z","timestamp":1749942354000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/INF.0000000000004355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/inf.0000000000004355","relation":{},"ISSN":["0891-3668"],"issn-type":[{"type":"print","value":"0891-3668"}],"subject":[],"published":{"date-parts":[[2024,4,10]]}}}