{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:47:54Z","timestamp":1768002474389,"version":"3.49.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Data on antifungal prescribing in neonatal patients are limited to either single-center or single-country studies or to 1-day recording. Therefore, we assessed antifungal longitudinal usage in neonatal units (NUs) within Europe.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>CALYPSO, a prospective weekly point prevalence study on antifungal drug usage in NUs in 18 hospitals (8 European countries), was conducted in 2020 during a 12-week period. All patients receiving systemic antifungals were included. Ward demographics were collected at the beginning; ward and patient data including indication, risk factors and antifungal regimen were weekly collected prospectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Among 27 participating NUs, 15 (56%) practiced antifungal prophylaxis for neonates with birth weight &lt;1000\u2009g or &lt;1500\u2009g and additional risk factors. In total, 174 patients received antifungals with a median frequency per week of 10.5% ranging from 6.9% to 12.6%. Indication for antifungal prescribing was prophylaxis in 135\/174 (78%) courses and treatment in 22% [39 courses (69% empirical, 10% preemptive, 21% targeted)]. Fluconazole was the most frequent systemic agent used both for prophylaxis (133\/135) and treatment (15\/39, 39%). Among neonates receiving prophylaxis, the most common risk factors were prematurity (119\/135, 88%), mechanical ventilation (109\/135, 81%) and central vascular catheters (89\/135, 66%). However, gestational age &lt;28 weeks was only recorded in 55\/135 (41%) courses and birth weight &lt;1000\u2009g in 48\/135 (35%). Most common reason for empirical treatment was late-onset sepsis; all 8 targeted courses were prescribed for invasive candidiasis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Antifungal usage in European NUs is driven by prophylaxis and empirical treatment with fluconazole being the most prescribed agent for both indications.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/inf.0000000000004445","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T16:03:42Z","timestamp":1719331422000},"page":"1047-1048","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Antifungal Drug Usage in European Neonatal Units: A Multicenter Weekly Point Prevalence Study"],"prefix":"10.1097","volume":"43","author":[{"given":"Elisavet","family":"Chorafa","sequence":"first","affiliation":[{"name":"From the Infectious Diseases Unit, 3rd Department of Pediatrics, Aristotle University School of Medicine, Hippokration Hospital, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Iosifidis","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, 3rd Department of Pediatrics, Aristotle University School of Medicine, Hippokration Hospital, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Oletto","sequence":"additional","affiliation":[{"name":"Fondazione Penta ETS, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilia","family":"Warris","sequence":"additional","affiliation":[{"name":"Medical Research Council Center for Medical Mycology, University of Exeter, Exeter, United Kingdom"},{"name":"European Pediatric Mycology 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lehrnbecher","sequence":"additional","affiliation":[{"name":"European Pediatric Mycology Network"},{"name":"Division of Hematology, Oncology and Hemostaseology, Department of Pediatrics, Goethe University Frankfurt, Frankfurt\/Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ferreras Antolin","sequence":"additional","affiliation":[{"name":"Medical Research Council Center for Medical Mycology, University of Exeter, Exeter, United Kingdom"},{"name":"European Pediatric Mycology Network"},{"name":"Pediatric Infectious Diseases and Immunology Unit, St George\u2019s University Hospitals, NHS Foundation Trust, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Mesini","sequence":"additional","affiliation":[{"name":"European Pediatric Mycology Network"},{"name":"Pediatric Infectious Diseases Unit, IRCCS 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