{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:24:38Z","timestamp":1783416278881,"version":"3.54.6"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Since March 2024, the European Center for Disease Prevention and Control has reported increased Parvovirus B19 (B19V) infections across 14 European countries. While often self-limiting in healthy children, B19V may cause severe disease in vulnerable populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter prospective study aimed to characterize the clinical presentation of B19V infection in hospitalized children and identify risk factors for severe outcomes. Data were collected through the INF-ACT pediatric surveillance system, as part of the National Recovery and Resilience Plan. Children hospitalized with confirmed B19V infection were enrolled from January to December 2024 in 10 Italian INF-ACT centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 135 children were included (median age 7.6 years, interquartile range 4.4\u20139.9), with 78.5% of cases occurring between April and July 2024. Acute myocarditis (20.7%) and neurologic complications (17.8%) were the most frequent severe manifestations. Myocarditis was significantly associated with younger age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), longer hospital stays (median 19.5 vs. 6.5 days;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0018) and higher intensive care unit (ICU) admission rates (71.4% vs. 20.8%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Multivariate analysis showed myocardial involvement increased the risk of ICU admission over 20-fold (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although often mild, B19V infection can cause severe complications in children, particularly myocarditis and neurologic involvement. Prompt recognition is essential, even in the absence of classic features like erythema infectiosum, to ensure timely monitoring and management of potentially life-threatening outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/inf.0000000000005014","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:19:22Z","timestamp":1760541562000},"page":"e37-e42","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Severe Presentations and Outcomes in Hospitalized Pediatric Patients With Parvovirus B19 Infection During the 2024 Outbreak: A Multicenter Prospective Study in Italy"],"prefix":"10.1097","volume":"45","author":[{"given":"Elisabetta","family":"Venturini","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Meyer Children\u2019s Hospital IRCCS, Florence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese Maria","family":"Tamborino","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Meyer Children\u2019s Hospital IRCCS, Florence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusy","family":"Arrichiello","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, Department of Maternal and Child health, University Hospital \u201cFederico II,\u201d"},{"name":"Department of Translational Medical Science, University of Naples \u201cFederico II,\u201d Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Attaianese","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Meyer Children\u2019s Hospital IRCCS, Florence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Ippolita","family":"Cal\u00f2 Carducci","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cafagno","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Children\u2019s Hospital Giovanni XXIII, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e","family":"Caselli","sequence":"additional","affiliation":[{"name":"Department of Consorziale Policlinico di Bari, Ospedale Pediatrico Giovanni XXIII, Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia","family":"De Luca","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Garbo","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo"},{"name":"Division of Paediatric Infectious Disease, \u201cG. Di Cristina\u201d Hospital, ARNAS Civico Di Cristina Benfratelli, Palermo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Giacomet","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, Department of Pediatrics, L. Sacco Hospital, University of Milan, Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Liberati","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Diseases, Department for Women\u2019s and Children\u2019s Health, University of Padua, Padua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lancella","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Licari","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia"},{"name":"Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Maglione","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Santobono-Pausilipon Children Hospital, Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Midulla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sapienza University of Rome, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Moracas","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, Department of Maternal and Child health, University Hospital \u201cFederico II,\u201d"},{"name":"PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Moriondo","sequence":"additional","affiliation":[{"name":"Pediatric Immunology Unit, Meyer Children\u2019s Hospital IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Poeta","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, Department of Maternal and Child health, University Hospital \u201cFederico II,\u201d"},{"name":"Department of Translational Medical Science, University of Naples \u201cFederico II,\u201d Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Rossini","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Children\u2019s Hospital Giovanni XXIII, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Guarino","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, Department of Maternal and Child health, University Hospital \u201cFederico II,\u201d"},{"name":"Department of Translational Medical Science, University of Naples \u201cFederico II,\u201d Naples"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7912-3366","authenticated-orcid":false,"given":"Luisa","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Consorziale Policlinico di Bari, Ospedale Pediatrico Giovanni XXIII, Bari"},{"name":"Department of Health Sciences, University of Florence, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4274\/balkanmedj.galenos.2025.2025-1-50","article-title":"Epidemiology of Parvovirus B19 in T\u00fcrkiye: a descriptive analysis of national surveillance data (2020-2024).","volume":"42","author":"Kalip","year":"2025","journal-title":"Balkan Med J"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/s00103-010-1109-9","article-title":"Parvovirus B19. 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