{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:49:21Z","timestamp":1791521361604,"version":"4.3.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NextGenerationEUMUR PNRR Extended Partnership initiative on Emerging Infectious Diseases","award":["PE00000007, INF-ACT"],"award-info":[{"award-number":["PE00000007, INF-ACT"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Human metapneumovirus (hMPV) is an important cause of pediatric lower respiratory tract infection. We describe the epidemiology and clinical severity of hMPV-associated pediatric hospitalizations in Italy in the post\u2013coronavirus disease 2019 period and identify predictors of pediatric intensive care unit (PICU) admission and prolonged hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a multicenter observational study across 11 tertiary care centers in Italy. Children hospitalized for \u226548 hours with laboratory-confirmed hMPV infection between January 2023 and June 2025 were included. Clinical features were analyzed overall and compared across co-infection categories and age groups. Associations with prolonged hospitalization (&gt;7 days) and PICU admission were evaluated using logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 312 children were hospitalized with hMPV infection (median age 14 months, interquartile range 5\u201336); 86.2% were &lt;5 years, and 44.6% were infants &lt;1 year. Oxygen supplementation was required in 67.5% of cases, and 10.6% were admitted to the PICU. Co-detected pathogens were identified in 47.1% of cases, without significant differences in severity or outcomes. Infants experienced more severe respiratory involvement, whereas older children more frequently had underlying comorbidities, radiologic consolidation and received antibiotics. In adjusted models, comorbidities, moderate-to-severe respiratory distress, dehydration and higher base excess were independently associated with prolonged hospitalization and PICU admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In the post\u2013coronavirus disease 2019 period, hMPV remains a clinically relevant cause of pediatric hospitalization, particularly among infants and children with underlying medical conditions. Simple bedside assessment of respiratory distress and hydration status may support early risk stratification and inform diagnostic-driven clinical management, including antimicrobial stewardship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/inf.0000000000005295","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:00:17Z","timestamp":1780372817000},"page":"957-963","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Features and Predictors of Severity in Children Hospitalized With Human Metapneumovirus"],"prefix":"10.1097","volume":"45","author":[{"given":"Sofia","family":"Sgubbi","sequence":"first","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy"},{"name":"Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Maria","family":"Corso","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy"},{"name":"Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7515-1394","authenticated-orcid":false,"given":"Marco","family":"Poeta","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, Department of Maternal and Child Health, University Hospital \u201cFederico II,\u201d Naples, Italy"},{"name":"Department of Translational Medical Science, University of Naples \u201cFederico II,\u201d Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Abrate","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics, Postgraduate School of Pediatrics, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Albano","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Disease, \u201cG. Di Cristina\u201d Hospital, ARNAS Civico Di Cristina Benfratelli, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Anania","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatrics, Postgraduate School of Pediatrics, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cafagno","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Children\u2019s Hospital Giovanni XXIII, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Colomba","sequence":"additional","affiliation":[{"name":"Division of Paediatric Infectious Disease, \u201cG. Di Cristina\u201d Hospital, ARNAS Civico Di Cristina Benfratelli, Palermo, Italy"},{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties \u201cG. D\u2019Alessandro\u201d, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia","family":"De Luca","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, IRCCS Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Denina","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Public Health and Pediatrics, University of Turin, Regina Margherita Children\u2019s Hospital, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Folgori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cV. 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Moracas","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Unit, Department of Maternal and Child Health, University Hospital \u201cFederico II,\u201d Naples, Italy"},{"name":"PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Moriondo","sequence":"additional","affiliation":[{"name":"Immunology Division, Section of Pediatrics, Meyer Children\u2019s Hospital IRCCS, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Petrarca","sequence":"additional","affiliation":[{"name":"Department of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, Rome, 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