{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:47:37Z","timestamp":1791355657187,"version":"4.3.1"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1097\/inf.0b013e3180618c42","type":"journal-article","created":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T04:03:14Z","timestamp":1185249794000},"page":"733-739","source":"Crossref","is-referenced-by-count":99,"title":["The Association Between Respiratory Syncytial Virus Infection and the Development of Childhood Asthma"],"prefix":"10.1097","volume":"26","author":[{"given":"Eduardo G.","family":"P\u00e9rez-Yarza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"L\u00e1zaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Mej\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Ramilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210202","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1056\/NEJM200106213442507","article-title":"Respiratory syncytial virus and parainfluenza virus.","volume":"344","author":"Hall","year":"2001","journal-title":"N Engl J Med"},{"key":"R2-14-20210202","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0140-6736(99)80040-3","article-title":"Respiratory syncytial virus infection.","volume":"354","author":"Simoes","year":"1999","journal-title":"Lancet"},{"key":"R3-14-20210202","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1017\/S0950268803008926","article-title":"Hospitalization for respiratory syncytial virus in paediatric population in Spain.","volume":"131","author":"Vicente","year":"2003","journal-title":"Epidemiol Infect"},{"key":"R4-14-20210202","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00006454-200207000-00005","article-title":"Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999.","volume":"21","author":"Leader","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"R5-14-20210202","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","article-title":"Bronchiolitis-associated hospitalizations among US children, 1980\u20131996.","volume":"282","author":"Shay","year":"1999","journal-title":"JAMA"},{"key":"R6-14-20210202","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaci.2006.05.025","article-title":"Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response.","volume":"118","author":"Schaller","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"R7-14-20210202","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1695-4033(02)77905-8","article-title":"Astma y virus sincitial respiratorio. Mito o realidad.","volume":"57","author":"Mejias","year":"2002","journal-title":"An Esp Pediatr"},{"key":"R8-14-20210202","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1164\/rccm.200308-1203OC","article-title":"Latency and persistence of respiratory syncytial virus despite T cell immunity.","volume":"169","author":"Schwarze","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"R9-14-20210202","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1743-422X-2-46","article-title":"Respiratory syncytial virus-induced acute and chronic airway disease is independent of genetic background: an experimental murine model.","volume":"2","author":"Chavez-Bueno","year":"2005","journal-title":"Virol J"},{"key":"R10-14-20210202","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1513\/pats.200502-014AW","article-title":"Cytokines and respiratory syncytial virus infection.","volume":"2","author":"Tripp","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"R11-14-20210202","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S1695-4033(04)78805-0","article-title":"Asthma and respiratory syncytial virus. New opportunities for therapeutic intervention.","volume":"61","author":"Mejias","year":"2004","journal-title":"An Pediatr (Barc)"},{"key":"R12-14-20210202","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0895-4356(96)00019-4","article-title":"Rating the quality of evidence for clinical practice guidelines.","volume":"49","author":"Hadorn","year":"1996","journal-title":"J Clin Epidemiol"},{"key":"R13-14-20210202","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/01.inf.0000122604.32137.29","article-title":"Impact of wheezing after respiratory syncytial virus infection on health-related quality of life.","volume":"23","author":"Bont","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"R14-14-20210202","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1164\/ajrccm.155.4.9105078","article-title":"Infant respiratory function after RSV-proven bronchiolitis.","volume":"155","author":"Dezateux","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"R15-14-20210202","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1067\/mpd.2001.114479","article-title":"The association between respiratory viruses and symptoms in 2-week-old infants at high risk for asthma and allergy.","volume":"138","author":"Hegele","year":"2001","journal-title":"J Pediatr"},{"key":"R16-14-20210202","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0091-6749(96)70131-8","article-title":"Induction of allergen-specific IL-2 responsiveness of lymphocytes after respiratory syncytial virus infection and prediction of onset of recurrent wheezing and bronchial asthma.","volume":"98","author":"Noma","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"R17-14-20210202","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1183\/09031936.02.00249902","article-title":"Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy.","volume":"20","author":"Pala","year":"2002","journal-title":"Eur Respir J"},{"key":"R18-14-20210202","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/ppul.20232","article-title":"Validation of a pediatric caregiver diary to measure symptoms of postacute respiratory syncytial virus bronchiolitis.","volume":"40","author":"Santanello","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"R19-14-20210202","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2004.06.038","article-title":"Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis.","volume":"114","author":"Heinzmann","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"R20-14-20210202","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archpedi.1994.02170100077015","article-title":"Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia. An 8-year follow-up study.","volume":"148","author":"Korppi","year":"1994","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R21-14-20210202","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1651-2227.1994.tb13131.x","article-title":"Bronchial asthma after early childhood wheezing: a follow-up until 4.5\u20136 years of age.","volume":"83","author":"Kuikka","year":"1994","journal-title":"Acta Paediatr"},{"key":"R22-14-20210202","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1053\/rmed.1999.0748","article-title":"Asthma and airway hyper-responsiveness in adults who required hospital admission for bronchiolitis in early childhood.","volume":"94","author":"Larouch","year":"2000","journal-title":"Respir Med"},{"issue":"Suppl 1","key":"R23-14-20210202","first-page":"S149","article-title":"Pulmonary function and exercise challenge test in Thai children: 10 years post respiratory syncytial virus infection.","volume":"82","author":"Lerdluedeeporn","year":"1999","journal-title":"J Med Assoc Thai"},{"key":"R24-14-20210202","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/adc.67.4.482","article-title":"Respiratory status and allergy after bronchiolitis.","volume":"67","author":"Murray","year":"1992","journal-title":"Arch Dis Child"},{"key":"R25-14-20210202","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/archpedi.158.11.1070","article-title":"Asthma and lung function 20 years after wheezing in infancy: results from a prospective follow-up study.","volume":"158","author":"Piippo-Savolainen","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R26-14-20210202","first-page":"233","article-title":"Correlaci\u00f3n bronquiolitis-asma. Estudio comparativo entre dos grupos de poblaci\u00f3n.","volume":"38","author":"Povoa","year":"1987","journal-title":"Archivos de Pediatr\u00eda"},{"key":"R27-14-20210202","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1651-2227.1997.tb09021.x","article-title":"Wheezing bronchitis reinvestigated at the age of 10 years.","volume":"86","author":"Wennergren","year":"1997","journal-title":"Acta Paediatr"},{"key":"R28-14-20210202","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/adc.72.1.16","article-title":"Lung function, airway responsiveness, and respiratory symptoms before and after bronchiolitis.","volume":"72","author":"Young","year":"1995","journal-title":"Arch Dis Child"},{"key":"R29-14-20210202","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1695-4033(01)77730-2","article-title":"Bronquiolitis y obstrucci\u00f3n bronquial: es la eosinofilia un factor de riesgo?","volume":"55","author":"Calvo","year":"2001","journal-title":"An Esp Pediatr"},{"key":"R30-14-20210202","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/08035250500499440","article-title":"Asthma symptoms in early childhood\u2014what happens then?","volume":"95","author":"Goks\u00f6r","year":"2006","journal-title":"Acta Paediatr"},{"key":"R31-14-20210202","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/adc.76.4.315","article-title":"Respiratory status and allergy nine to 10 years after acute bronchiolitis.","volume":"76","author":"Noble","year":"1997","journal-title":"Arch Dis Child"},{"key":"R32-14-20210202","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-2222.2004.1947.x","article-title":"Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis.","volume":"34","author":"Goetghebuer","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"R33-14-20210202","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1034\/j.1399-3038.2000.00068.x","article-title":"Inhaled corticosteroids during and after respiratory syncytial virus-bronchiolitis may decrease subsequent asthma.","volume":"11","author":"Kajosaari","year":"2000","journal-title":"Pediatr Allergy Immunol"},{"key":"R34-14-20210202","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/archpedi.153.5.469","article-title":"Prospective follow-up and pulmonary functions from a placebo-controlled randomized trial of ribavirin therapy in respiratory syncytial virus bronchiolitis. Ribavirin Study Group.","volume":"153","author":"Rodriguez","year":"1999","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R35-14-20210202","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0002-9343(02)01095-1","article-title":"Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin.","volume":"112","author":"Wenzel","year":"2002","journal-title":"Am J Med"},{"key":"R35A-14-20210202","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/ppul.10365","article-title":"Risk factors for recurrent wheezing following acute bronchiolitis: a 12-month follow-up.","volume":"36","author":"Cifuentes","year":"2003","journal-title":"Pediatr Pulmonol"},{"key":"R35B-14-20210202","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1034\/j.1399-3038.2000.00076.x","article-title":"Wheezing following lower respiratory tract infections with respiratory syncytial virus and influenza A in infancy.","volume":"11","author":"Eriksson","year":"2000","journal-title":"Pediatr Allergy Immunol"},{"key":"R35C-14-20210202","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1651-2227.2005.tb01807.x","article-title":"Teenage asthma after severe infantile bronchiolitis or pneumonia.","volume":"94","author":"Hyv\u00e4rinen","year":"2005","journal-title":"Acta Paediatr"},{"key":"R35D-14-20210202","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/ppul.20273","article-title":"Teenage asthma after severe early childhood wheezing: an 11-year prospective follow-up.","volume":"40","author":"Hyv\u00e4rinen","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"R35E-14-20210202","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1034\/j.1399-3038.2002.02091.x","article-title":"Wheezing requiring hospitalization in early childhood: predictive factors for asthma in a six-year follow-up.","volume":"13","author":"Kotaniemi-Syrjanen","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"R35F-14-20210202","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1542\/peds.106.6.1406","article-title":"Predictors of asthma three years after hospital admission for wheezing in infancy.","volume":"106","author":"Reijonen","year":"2000","journal-title":"Pediatrics"},{"key":"R36-14-20210202","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/08035250410025069","article-title":"Respiratory syncytial virus infection in children hospitalized for wheezing: virus-specific studies from infancy to preschool years.","volume":"94","author":"Kotaniemi-Syrjanen","year":"2005","journal-title":"Acta Paediatr"},{"key":"R37-14-20210202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-3038.1997.tb00134.x","article-title":"Association between pronounced IgA response in RSV bronchiolitis and development of allergic sensitization.","volume":"8","author":"Strannegard","year":"1997","journal-title":"Pediatr Allergy Immunol"},{"key":"R38-14-20210202","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0301-0546(01)79034-9","article-title":"Infecci\u00f3n por el virus respiratorio sincitial y asma.","volume":"29","author":"Mart\u00edn","year":"2001","journal-title":"Allergol et Immunopathol (Madrid)"},{"key":"R39-14-20210202","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1526-0542(02)00191-4","article-title":"A cohort of children hospitalised with acute RSV bronchiolitis: impact on later respiratory disease.","volume":"3","author":"Sigurs","year":"2002","journal-title":"Paediatr Respir Rev"},{"issue":"Suppl","key":"R40-14-20210202","first-page":"S17","article-title":"RSV and reactive airway disease: is there an association?","volume":"2-4","author":"Piedimonte","year":"2000","journal-title":"J Resp Dis Ped"},{"key":"R41-14-20210202","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/088318701753436853","article-title":"Respiratory syncytial virus: an association with severe asthma exacerbations in children of all ages.","volume":"15","author":"Smith","year":"2001","journal-title":"Pediatric Asthma Allergy Immunol"},{"key":"R42-14-20210202","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1164\/ajrccm.161.5.9904078","article-title":"Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study.","volume":"161","author":"Bont","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"R43-14-20210202","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00006454-200103000-00012","article-title":"Airflow limitation during respiratory syncytial virus lower respiratory tract infection predicts recurrent wheezing.","volume":"20","author":"Bont","year":"2001","journal-title":"Pediatr Infect Dis J"},{"issue":"1,","key":"R44-14-20210202","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1542\/peds.105.1.79","article-title":"Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease.","volume":"105","author":"Ehlenfield","year":"2000","journal-title":"Pediatrics"},{"key":"R45-14-20210202","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ppul.1069","article-title":"Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing.","volume":"31","author":"Pifferi","year":"2001","journal-title":"Pediatr Pulmonol"},{"key":"R46-14-20210202","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S1081-1206(10)61762-0","article-title":"Soluble CD14 as a predictor of subsequent development of recurrent wheezing in hospitalized young children with respiratory syncytial virus-induced bronchiolitis.","volume":"92","author":"Soferman","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R47-14-20210202","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ppul.1950070307","article-title":"Childhood asthma following hospitalization with acute viral bronchiolitis in infancy.","volume":"7","author":"Sly","year":"1989","journal-title":"Pediatr Pulmonol"},{"key":"R48-14-20210202","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ppul.1950150104","article-title":"The relationship of RSV-specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7\u20138 years.","volume":"15","author":"Welliver","year":"1993","journal-title":"Pediatr Pulmonol"},{"key":"R49-14-20210202","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years.","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"R50-14-20210202","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1399-3038.2005.00298.x","article-title":"Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study.","volume":"16","author":"Henderson","year":"2005","journal-title":"Pediatr Allergy Immunol"},{"key":"R51-14-20210202","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2431-5-31","article-title":"Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway.","volume":"5","author":"Fjaerli","year":"2005","journal-title":"BMC Pediatr"},{"key":"R52-14-20210202","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1034\/j.1398-9995.2003.00233.x","article-title":"Association of an early respiratory syncytial virus infection and atopic allergy.","volume":"58","author":"Juntti","year":"2003","journal-title":"Allergy"},{"key":"R53-14-20210202","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ppul.20058","article-title":"Respiratory morbidity 20 years after RSV infection in infancy.","volume":"38","author":"Korppi","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"R54-14-20210202","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/BF01957225","article-title":"Recurrent wheezing in children with respiratory syncytial virus (RSV) bronchiolitis in Qatar.","volume":"152","author":"Osundwa","year":"1993","journal-title":"Eur J Pediatr"},{"key":"R55-14-20210202","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1183\/09031936.02.00019902","article-title":"RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life.","volume":"20","author":"Schauer","year":"2002","journal-title":"Eur Respir J"},{"key":"R56-14-20210202","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1542\/peds.95.4.500","article-title":"Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls.","volume":"95","author":"Sigurs","year":"1995","journal-title":"Pediatrics"},{"key":"R57-14-20210202","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.161.5.9906076","article-title":"Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7.","volume":"161","author":"Sigurs","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"R58-14-20210202","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13.","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R59-14-20210202","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.112.2.285","article-title":"Sequelae of severe respiratory syncytial virus infection in infancy and early childhood among Alaska Native children.","volume":"112","author":"Singleton","year":"2003","journal-title":"Pediatrics"},{"key":"R60-14-20210202","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0022-3476(99)70085-5","article-title":"Respiratory illness after severe respiratory syncytial virus disease in infancy in The Gambia.","volume":"135","author":"Weber","year":"1999","journal-title":"J Pediatr"}],"container-title":["Pediatric Infectious Disease Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/INF.0b013e3180618c42","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:54:33Z","timestamp":1786035273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006454-200708000-00014"}},"subtitle":["A Systematic Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":66,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/inf.0b013e3180618c42","relation":{},"ISSN":["0891-3668"],"issn-type":[{"value":"0891-3668","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}