{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:39:02Z","timestamp":1782520742346,"version":"3.54.5"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>A 53-year-old man presented with smooth-domed, variegated cysts (polycystic disease) of all 4 eyelids, worse on the left side. Some of the cysts were clear, while others were creamy-white colored. In addition, multiple, very fine vesicopapules were noted along the eyelid margins. Histopathologic examination revealed a trichilemmal cyst, several pure apocrine hidrocystomas displaying multiple chambers, a hybrid cyst, and many small eccrine cysts of the deep dermis. The apocrine lesions, including the small ones at the eyelid margins, predominated. Smooth muscle actin sometimes positively stained outer myoepithelial cells in some of the apocrine cysts, which helped to distinguish them from eccrine cysts. Most noteworthy was the fact that the patient had been diagnosed with a prolactinoma 20 years earlier. There is only 1 previous report of multiple apocrine cysts and an antecedent prolactinoma in the dermatologic literature. This syndrome should be separated from that of Sch\u00f6pf\u2013Schulz\u2013Passarge, which manifests multiple small eyelid apocrine cysts and other ectodermal dysplasias without any association with neoplasia, and from that of focal dermal hypoplasia (Goltz\u2013Gorlin) syndrome with apocrine cysts but again without neoplasia.<\/jats:p>","DOI":"10.1097\/iop.0000000000001069","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T15:11:10Z","timestamp":1516374670000},"page":"e83-e85","source":"Crossref","is-referenced-by-count":6,"title":["Multiple Eyelid Cysts (Apocrine and Eccrine Hidrocystomas, Trichilemmal Cyst, and Hybrid Cyst) in a Patient With a Prolactinoma"],"prefix":"10.1097","volume":"34","author":[{"given":"Lina","family":"Ma","sequence":"first","affiliation":[{"name":"David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Jakobiec","sequence":"additional","affiliation":[{"name":"David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Wolkow","sequence":"additional","affiliation":[{"name":"David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus P.","family":"Dryja","sequence":"additional","affiliation":[{"name":"David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Borodic","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA and Associate Eye Physicians and Surgeons, Quincy, Massachusetts, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230817","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-2133.1997.tb03803.x","article-title":"Multiple apocrine hidrocystomas of the eyelids.","volume":"137","author":"Alessi","year":"1997","journal-title":"Br J Dermatol"},{"key":"R2-20230817","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0161-6420(87)33501-8","article-title":"Multiple bilateral apocrine cystadenomas of the lower eyelids. Light and electron microscopic studies.","volume":"94","author":"Sacks","year":"1987","journal-title":"Ophthalmology"},{"key":"R3-20230817","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/IOP.0b013e3181b9e87b","article-title":"Palpebro-orbital apocrine cystadenoma: immunohistochemical verification of a unique variant with a critical differential diagnosis.","volume":"26","author":"Jakobiec","year":"2010","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"R4-20230817","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.eye.6701404","article-title":"Eccrine hidrocystoma of the eyelid.","volume":"19","author":"Singh","year":"2005","journal-title":"Eye (Lond)"},{"key":"R5-20230817","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ajo.2010.08.028","article-title":"A reappraisal of eyelid eccrine and apocrine hidrocystomas: microanatomic and immunohistochemical studies of 40 lesions.","volume":"151","author":"Jakobiec","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"R6-20230817","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1097\/IOP.0000000000000855","article-title":"Eyelid eccrine cyst: an exceptional lesion among dominant apocrine cysts.","volume":"33","author":"Jakobiec","year":"2017","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"R7-20230817","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/IOP.0b013e3181647ce9","article-title":"Hybrid cysts of the eyelid with follicular and apocrine differentiation: an under-recognized entity?","volume":"24","author":"Milman","year":"2008","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"R8-20230817","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000246098","article-title":"Multiple Moll\u2019s gland cysts (apocrine hidrocystomas) of the eyelids.","volume":"194","author":"Combemale","year":"1997","journal-title":"Dermatology"},{"key":"R9-20230817","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000017951","article-title":"The Sch\u00f6pf-Schulz-Passarge syndrome.","volume":"196","author":"Verplancke","year":"1998","journal-title":"Dermatology"},{"key":"R10-20230817","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/bjd.13158","article-title":"Clinical features and WNT10A mutations in seven unrelated cases of Sch\u00f6pf-Schulz-Passarge syndrome.","volume":"171","author":"Tziotzios","year":"2014","journal-title":"Br J Dermatol"},{"key":"R11-20230817","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/archderm.1992.01680180072008","article-title":"Focal dermal hypoplasia syndrome in a male patient. Report of a case and histologic and immunohistochemical studies.","volume":"128","author":"B\u00fcchner","year":"1992","journal-title":"Arch Dermatol"}],"container-title":["Ophthalmic Plastic &amp; Reconstructive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00002341-201805000-00033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T21:08:32Z","timestamp":1692306512000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00002341-201805000-00033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/iop.0000000000001069","relation":{},"ISSN":["0740-9303"],"issn-type":[{"value":"0740-9303","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}