{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:03:07Z","timestamp":1768924987356,"version":"3.49.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>The authors report a case of extremely uncommon malignancy of lacrimal gland epithelial-myoepithelial carcinoma. This carcinoma is more commonly encountered in salivary glands and comprises 1% of all salivary gland tumors. Its occurrence in the orbit is very rare with only 6 cases reported in the literature, most of which arose in a pleomorphic adenoma. Epithelial-myoepithelial carcinoma is primarily a tumor of older adults, with a peak incidence in the sixth and seventh decades of life. The present case is the youngest patient reported to date and had no history of preexisting neoplasm in the lacrimal gland. Histological diagnosis of epithelial-myoepithelial carcinoma is challenging because of the similarity with other lacrimal gland epithelial tumors like malignant adenoid cystic carcinoma and benign pleomorphic adenomas.<\/jats:p>","DOI":"10.1097\/iop.0000000000001663","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T05:54:57Z","timestamp":1587794097000},"page":"e141-e144","source":"Crossref","is-referenced-by-count":4,"title":["Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland: Case Report of Youngest Patient"],"prefix":"10.1097","volume":"36","author":[{"given":"Shahzan","family":"Anjum","sequence":"first","affiliation":[{"name":"Ocular Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujeeth","family":"Modaboyina","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Sen","sequence":"additional","affiliation":[{"name":"Ocular Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehar Chand","family":"Sharma","sequence":"additional","affiliation":[{"name":"Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachna","family":"Meel","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,4,22]]},"reference":[{"key":"R1-20230829","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.anndiagpath.2011.02.004","article-title":"Epithelial-myoepithelial carcinoma of the lacrimal gland: a rare case.","volume":"16","author":"Singh","year":"2012","journal-title":"Ann Diagn Pathol"},{"key":"R2-20230829","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0161-6420(94)31236-X","article-title":"Clear cell epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the lacrimal gland.","volume":"101","author":"Ostrowski","year":"1994","journal-title":"Ophthalmology"},{"key":"R3-20230829","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1001\/archopht.122.11.1714","article-title":"Primary epithelial-myoepithelial carcinoma of the lacrimal gland.","volume":"122","author":"Chan","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"R4-20230829","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1001\/archophthalmol.2009.195","article-title":"Unusual carcinomas of the lacrimal gland: epithelial-myoepithelial carcinoma and myoepithelial carcinoma.","volume":"127","author":"Wiwatwongwana","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"R5-20230829","first-page":"e42","article-title":"Epithelial-myoepithelial carcinoma of the lacrimal gland 14 years after en bloc resection of a pleomorphic lacrimal gland adenoma.","volume":"32","author":"Allan","year":"2014","journal-title":"Ophthal mic Plast Reconstr Surg"},{"key":"R6-20230829","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-210795","article-title":"Epithelial-myoepithelial carcinoma of the lacrimal gland from an ex pleomorphic adenoma.","author":"Venkatesulu","year":"2015","journal-title":"BMJ Case Rep"},{"key":"R7-20230829","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/archophthalmol.2009.209","article-title":"Epithelial lacrimal gland tumors: pathologic classification and current understanding.","volume":"127","author":"Weis","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"R8-20230829","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/01.pas.0000213314.74423.d8","article-title":"Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract.","volume":"31","author":"Seethala","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"R9-20230829","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/2231-0746.133085","article-title":"Epithelial-myoepithelial carcinoma of the parotid gland: clinicopathological aspect, diagnosis and surgical consideration.","volume":"4","author":"Massimo","year":"2014","journal-title":"Ann Maxillofac Surg"},{"key":"R10-20230829","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1002\/cncr.25813","article-title":"Outcomes of malignant tumors of the lacrimal apparatus: the University of Texas MD Anderson Cancer Center experience.","volume":"117","author":"Skinner","year":"2011","journal-title":"Cancer"}],"container-title":["Ophthalmic Plastic &amp; Reconstructive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/IOP.0000000000001663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T02:20:08Z","timestamp":1693275608000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/IOP.0000000000001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,22]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/iop.0000000000001663","relation":{},"ISSN":["0740-9303"],"issn-type":[{"value":"0740-9303","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,22]]}}}