{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:39:30Z","timestamp":1772548770422,"version":"3.50.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>Monocyte-lymphocyte ratio (MLR) and platelet-lymphocyte ratio (PLR) are emerging biomarkers; they have not been widely utilized in orbital disease. This study investigated the role of these ratios in distinguishing orbital inflammation from infection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A retrospective review of medical records was conducted to identify adult patients who presented acutely to a single emergency department at an academic medical center and were diagnosed with serologically and biopsy-proven idiopathic orbital inflammation (IOI, n = 9), orbital cellulitis (OC, n = 14), or necrotizing fasciitis (NF, n = 12). MLR and PLR were calculated from the first blood draw on presentation to the emergency department. Statistical analysis was performed via the Mann\u2013Whitney test with a dedicated computerized software package (GraphPad Prism, La Jolla, CA) with <jats:italic toggle=\"yes\">p<\/jats:italic> values &lt;0.05 considered statistically significant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Mean PLRs were 194.90 (SD = 118.01), 304.21 (SD = 341.39), and 203.38 (SD = 196.32) for IOI, NF, and OC, respectively. Mean MLRs were 0.40 (SD = 0.24), 1.74 (SD = 2.41), and 0.75 (SD = 0.40) for IOI, NF, and OC, respectively. MLR was significantly lower in the IOI group compared to the NF group (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.018) and OC group (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.020). Differences in MLR between OC and NF groups were not statistically significant (<jats:italic toggle=\"yes\">p<\/jats:italic> = 0.43).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>While MLR showed no significant difference between different infectious etiologies, it was significantly higher in infectious processes than in IOI, distinguishing inflammation from infection. MLR could be a valuable addition to the diagnostic toolkit for triaging patients in the emergency department and initiating prompt, focused therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/iop.0000000000002829","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T18:01:05Z","timestamp":1733767265000},"page":"303-305","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Value of Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratios in Differentiating Idiopathic Orbital Inflammation From Orbital Infectious Disease"],"prefix":"10.1097","volume":"41","author":[{"given":"Robert J.","family":"Thomson","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Lions Eye Institute, Albany Medical College, Albany, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carisa 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