{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:06:22Z","timestamp":1786118782335,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1097\/iop.0b013e318030459c","type":"journal-article","created":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T04:03:10Z","timestamp":1174276990000},"page":"130-133","source":"Crossref","is-referenced-by-count":38,"title":["Efficacy of Skin Cooling and EMLA Cream Application for Pain Relief of Periocular Botulinum Toxin Injection"],"prefix":"10.1097","volume":"23","author":[{"given":"Orhan","family":"Elibol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin Kaynak","family":"Hekimhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"\u00c7a\u011flar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20210129","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0039-6257(91)90207-V","article-title":"Botulinum A toxin (Oculinum) in ophthalmology.","volume":"36","author":"Osako","year":"1991","journal-title":"Surv Ophthalmol"},{"key":"R2-11-20210129","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/archopht.1985.01050030043017","article-title":"Botulinum toxin injection as a treatment for blepharospasm.","volume":"103","author":"Scott","year":"1985","journal-title":"Arch Ophthalmol"},{"key":"R3-11-20210129","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0039-6257(97)81995-9","article-title":"Botulinum A toxin in the treatment of craniocervical muscle spasms: Short and long-term, local and systemic effects.","volume":"41","author":"Dutton","year":"1996","journal-title":"Surv Ophthalmol"},{"key":"R4-11-20210129","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00266-002-2030-x","article-title":"Indications and limitations for the use of Botulinum toxin for the treatment of facial wrinkles.","volume":"26","author":"Sarrabayrouse","year":"2002","journal-title":"Aesth Plast Surg"},{"key":"R5-11-20210129","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00004397-200404410-00018","article-title":"Injectible agents for facial rejuvenation: Botulinum toxin and dermal filling agents.","volume":"44","author":"Mandeville","year":"2004","journal-title":"Int Ophthalmol Clin"},{"key":"R6-11-20210129","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/01.iio.0000167241.28311.48","article-title":"Selective Botulinum neurotoxin injection. Cosmetic Botulinum neurotoxin application.","volume":"45","author":"Khan","year":"2005","journal-title":"Int Ophthalmol Clin"},{"key":"R7-11-20210129","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/jnnp.51.6.767","article-title":"Blepharospasm: A review of 264 patients.","volume":"51","author":"Grandas","year":"1988","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"R8-11-20210129","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000066186","article-title":"Anesthesia with EMLA cream for botulinum A toxin injection into eyelids.","volume":"216","author":"Soylev","year":"2002","journal-title":"Ophthalmologica"},{"key":"R9-11-20210129","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3959(95)00100-X","article-title":"Determinants of success and failure of EMLA.","volume":"64","author":"Lander","year":"1996","journal-title":"Pain"},{"key":"R10-11-20210129","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00002341-200211000-00010","article-title":"Skin cooling before periocular botulinum toxin injection.","volume":"18","author":"Linder","year":"2002","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"R11-11-20210129","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/01.sap.0000139563.51598.75","article-title":"Evaluating the effects of ice application on the pain felt during Botulinum toxin type-A injections. A prospective, randomized, single blind controlled trial.","volume":"53","author":"Sarifakioglu","year":"2004","journal-title":"Ann Plast Surg"},{"key":"R12-11-20210129","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ajo.2004.04.011","article-title":"Lidocaine tape (Penles) reduces the pain of botulinum toxin injection for Meige Syndrome.","volume":"138","author":"Onguchi","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"R13-11-20210129","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archderm.138.4.510","article-title":"Pain associated with injection of Botulinum A exotoxin reconstituted using isotonic sodium chloride with and without preservative: a double-blind, randomized controlled trial.","volume":"138","author":"Alam","year":"2002","journal-title":"Arch Dermatol"},{"key":"R14-11-20210129","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0025-6196(11)64616-8","article-title":"Addition of an anesthetic agent to enhance the predictability of the effects of Botulinum toxin type A injections: a randomized controlled study.","volume":"75","author":"Gassner","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"R15-11-20210129","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0020-7489(00)00061-4","article-title":"The effect of cold on the occurrence of bruising, heamatoma and pain at the injection site in subcutaneous low molecular weight heparin.","volume":"38","author":"Kuzu","year":"2001","journal-title":"Int J Nursing Studies"},{"key":"R16-11-20210129","first-page":"1057","article-title":"Cryoanalgesia with dichlorotetrafluoroethane lessens the pain of Botulinum toxin injections for the treatment of palmar hyperhidrosis.","volume":"29","author":"Baumann","year":"2003","journal-title":"Dermatol Surg"},{"key":"R17-11-20210129","first-page":"495","article-title":"EMLA versus ice as a topical anesthetic.","volume":"27","author":"Kuwahara","year":"2001","journal-title":"Dermatol Surg"},{"key":"R18-11-20210129","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0536.1997.tb00915.x","article-title":"Purpura caused by EMLA is of toxic origin.","volume":"36","author":"Van den Spek","year":"1997","journal-title":"Contact Dermatitis"},{"key":"R19-11-20210129","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1034\/j.1600-0560.2002.290312.x","article-title":"EMLA cream induced irritant contact dermatitis.","volume":"29","author":"Dong","year":"2002","journal-title":"J Cutan Pathol"},{"key":"R20-11-20210129","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.0105-1873.2004.00475.x","article-title":"Contact urticaria from EMLA cream.","volume":"51","author":"Waton","year":"2004","journal-title":"Contact Dermatitis"},{"key":"R21-11-20210129","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1067\/mjd.2000.104303","article-title":"Depth of cutaneous analgesia after application of eutectic mixture of local anesthetics lidocaine and prilocaine (EMLA cream).","volume":"42","author":"Wahlgren","year":"2000","journal-title":"J Am Acad Dermatol"}],"container-title":["Ophthalmic Plastic & Reconstructive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/IOP.0b013e318030459c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:34:59Z","timestamp":1786034099000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002341-200703000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/iop.0b013e318030459c","relation":{},"ISSN":["0740-9303"],"issn-type":[{"value":"0740-9303","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}