{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T12:37:43Z","timestamp":1751459863163},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1097\/jcma.0000000000000063","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T18:37:01Z","timestamp":1562783821000},"page":"568-575","source":"Crossref","is-referenced-by-count":5,"title":["Effects of intravenous phosphodiesterase inhibitors and corticosteroids on severe meconium aspiration syndrome"],"prefix":"10.1097","volume":"82","author":[{"given":"Ju-Ing","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hsueh","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hsin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Jy","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-10-20210129","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1203\/01.PDR.0000082017.97479.39","article-title":"Meconium is a source of pro-inflammatory substances and can induce cytokine production in cultured A549 epithelial cells.","volume":"54","author":"de Beaufort","year":"2003","journal-title":"Pediatr Res"},{"key":"R2-10-20210129","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1203\/00006450-199808000-00008","article-title":"Morphology and function of pulmonary surfactant inhibited by meconium.","volume":"44","author":"Bae","year":"1998","journal-title":"Pediatr Res"},{"key":"R3-10-20210129","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1542\/peds.100.6.998","article-title":"Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration.","volume":"100","author":"Cleary","year":"1997","journal-title":"Pediatrics"},{"key":"R4-10-20210129","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ppul.1950160205","article-title":"Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model.","volume":"16","author":"Davey","year":"1993","journal-title":"Pediatr Pulmonol"},{"key":"R5-10-20210129","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000318748","article-title":"Meconium aspiration delays normal decline of pulmonary vascular resistance shortly after birth through lung parenchymal injury.","volume":"99","author":"Ban","year":"2011","journal-title":"Neonatology"},{"key":"R6-10-20210129","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.jpeds.2010.11.008","article-title":"Pulmonary hypertension and the asphyxiated newborn.","volume":"158","author":"Lapointe","year":"2011","journal-title":"J Pediatr"},{"key":"R7-10-20210129","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bpa.2010.02.021","article-title":"Pulmonary hypertension of the newborn.","volume":"24","author":"Stayer","year":"2010","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"R8-10-20210129","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.acvd.2012.12.005","article-title":"Pathophysiology of persistent pulmonary hypertension of the newborn: impact of the perinatal environment.","volume":"106","author":"Storme","year":"2013","journal-title":"Arch Cardiovasc Dis"},{"key":"R9-10-20210129","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1053\/j.semperi.2013.11.004","article-title":"Update on PPHN: mechanisms and treatment.","volume":"38","author":"Nair","year":"2014","journal-title":"Semin Perinatol"},{"key":"R10-10-20210129","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1203\/00006450-199911000-00022","article-title":"Human meconium has high phospholipase A2 activity and induces cellular injury and apoptosis in piglet lungs.","volume":"46","author":"Holopainen","year":"1999","journal-title":"Pediatr Res"},{"key":"R11-10-20210129","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1203\/00006450-200102000-00006","article-title":"Dexamethasone treatment attenuates pulmonary injury in piglet meconium aspiration.","volume":"49","author":"Holopainen","year":"2001","journal-title":"Pediatr Res"},{"key":"R12-10-20210129","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1038\/jp.2008.147","article-title":"Phospholipase A2 in meconium-induced lung injury.","volume":"28","author":"Kaapa","year":"2008","journal-title":"J Perinatol"},{"key":"R13-10-20210129","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1021\/bp0497886","article-title":"Inflammatory response and apoptosis in newborn lungs after meconium aspiration.","volume":"21","author":"Vidyasagar","year":"2005","journal-title":"Biotechnol Prog"},{"key":"R14-10-20210129","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1038\/jp.2008.153","article-title":"Studies of meconium-induced lung injury: inflammatory cytokine expression and apoptosis.","volume":"28","author":"Vidyasagar","year":"2008","journal-title":"J Perinatol"},{"key":"R15-10-20210129","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.lfs.2004.10.033","article-title":"Apoptosis of airway epithelial cells in response to meconium.","volume":"76","author":"Zagariya","year":"2005","journal-title":"Life Sci"},{"key":"R16-10-20210129","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1542\/peds.2005-0274","article-title":"Inhibition of meconium-induced cytokine expression and cell apoptosis by pretreatment with captopril.","volume":"117","author":"Zagariya","year":"2006","journal-title":"Pediatrics"},{"key":"R17-10-20210129","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s004310000581","article-title":"Cell death and lung cell histology in meconium aspirated newborn rabbit lung.","volume":"159","author":"Zagariya","year":"2000","journal-title":"Eur J Pediatr"},{"key":"R18-10-20210129","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0970-2113.80324","article-title":"Corticosteroids and ARDS: a review of treatment and prevention evidence.","volume":"28","author":"Khilnani","year":"2011","journal-title":"Lung India"},{"key":"R19-10-20210129","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/CCM.0b013e31819fb507","article-title":"Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis.","volume":"37","author":"Tang","year":"2009","journal-title":"Crit Care Med"},{"key":"R20-10-20210129","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1203\/00006450-199908000-00009","article-title":"Effects of dexamethasone on meconium aspiration syndrome in newborn piglets.","volume":"46","author":"Khan","year":"1999","journal-title":"Pediatr Res"},{"key":"R21-10-20210129","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ppul.20330","article-title":"Dexamethasone alleviates meconium-induced airway hyperresponsiveness and lung inflammation in rabbits.","volume":"41","author":"Mokry","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"R22-10-20210129","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1203\/00006450-199708000-00003","article-title":"Methylprednisolone attenuates the pulmonary hypertensive response in porcine meconium aspiration.","volume":"42","author":"Soukka","year":"1997","journal-title":"Pediatr Res"},{"key":"R23-10-20210129","first-page":"751","article-title":"Short-term cardiovascular effects of selective phosphodiesterase 3 inhibitor olprinone versus non-selective phosphodiesterase inhibitor aminophylline in a meconium-induced acute lung injury.","volume":"64","author":"Mokra","year":"2013","journal-title":"J Physiol Pharmacol"},{"key":"R24-10-20210129","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/978-94-007-4549-0_41","article-title":"Cardiovascular side effects of aminophylline in meconium-induced acute lung injury.","volume":"756","author":"Mokra","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"R25-10-20210129","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/01902149709039229","article-title":"Postexposure treatment with aminophylline protects against phosgene-induced acute lung injury.","volume":"23","author":"Sciuto","year":"1997","journal-title":"Exp Lung Res"},{"key":"R26-10-20210129","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-94-007-4549-0_24","article-title":"Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury.","volume":"756","author":"Mokra","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"R27-10-20210129","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1183\/09031936.00071307","article-title":"Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury.","volume":"31","author":"de Visser","year":"2008","journal-title":"Eur Respir J"},{"key":"R28-10-20210129","doi-asserted-by":"crossref","first-page":"L56","DOI":"10.1152\/ajplung.00041.2011","article-title":"Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats.","volume":"302","author":"de Visser","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R29-10-20210129","doi-asserted-by":"crossref","first-page":"e3445","DOI":"10.1371\/journal.pone.0003445","article-title":"Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats.","volume":"3","author":"Mehats","year":"2008","journal-title":"PLoS One"},{"key":"R30-10-20210129","doi-asserted-by":"crossref","first-page":"e287","DOI":"10.1097\/PCC.0000000000000729","article-title":"Effects of surfactant lavage combined with intratracheal budesonide instillation on meconium-injured piglet lungs.","volume":"17","author":"Lin","year":"2016","journal-title":"Pediatr Crit Care Med"},{"key":"R31-10-20210129","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1203\/PDR.0b013e3181a29092","article-title":"Effective lavage volume of diluted surfactant improves the outcome of meconium aspiration syndrome in newborn piglets.","volume":"66","author":"Jeng","year":"2009","journal-title":"Pediatr Res"},{"key":"R32-10-20210129","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.2017.21907","article-title":"Acute respiratory distress syndrome: advances in diagnosis and treatment.","volume":"319","author":"Fan","year":"2018","journal-title":"JAMA"},{"key":"R36-10-20210129","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/1472-6963-7-188","article-title":"Using hospital discharge data for determining neonatal morbidity and mortality: a validation study.","volume":"7","author":"Ford","year":"2007","journal-title":"BMC Health Serv Res"},{"key":"R37-10-20210129","first-page":"138","article-title":"Inhaled nitric oxide in the treatment of persistent pulmonary hypertension\/ hypoxic respiratory failure in neonates: an update.","volume":"103","author":"Cook","year":"2005","journal-title":"J Ky Med Assoc"},{"key":"R38-10-20210129","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1365-2125.2008.03155.x","article-title":"Phosphodiesterase 4 inhibitors in chronic obstructive pulmonary disease: a new approach to oral treatment.","volume":"65","author":"Currie","year":"2008","journal-title":"Br J Clin Pharmacol"},{"key":"R39-10-20210129","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.resp.2013.02.004","article-title":"Immunological aspects of phosphodiesterase inhibition in the respiratory system.","volume":"187","author":"Mokry","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"R40-10-20210129","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2005.12.059","article-title":"Phosphodiesterase inhibitors in airways disease.","volume":"533","author":"Fan Chung","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"R41-10-20210129","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.coph.2012.02.016","article-title":"Selective PDE inhibitors as novel treatments for respiratory diseases.","volume":"12","author":"Page","year":"2012","journal-title":"Curr Opin Pharmacol"},{"key":"R42-10-20210129","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/bjp.2008.307","article-title":"PDE4 inhibitors: current status.","volume":"155","author":"Spina","year":"2008","journal-title":"Br J Pharmacol"},{"key":"R43-10-20210129","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1165\/rcmb.2014-0344OC","article-title":"Inhibitors of phosphodiesterase 4, but not phosphodiesterase 3, increase \u03b22-agonist-induced expression of antiinflammatory mitogen-activated protein kinase phosphatase 1 in airway smooth muscle cells.","volume":"52","author":"Patel","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"R44-10-20210129","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(05)17708-3","article-title":"Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease.","volume":"365","author":"Lipworth","year":"2005","journal-title":"Lancet"},{"key":"R45-10-20210129","first-page":"969","article-title":"Vulnerable COPD patients with comorbidities: the role of roflumilast.","volume":"10","author":"Lipari","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"R46-10-20210129","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1476-5381.1992.tb14451.x","article-title":"Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors.","volume":"106","author":"de Boer","year":"1992","journal-title":"Br J Pharmacol"},{"key":"R47-10-20210129","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S2213-2600(13)70187-5","article-title":"Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.","volume":"1","author":"Franciosi","year":"2013","journal-title":"Lancet Respir Med"},{"key":"R48-10-20210129","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1476-5381.2009.00170.x","article-title":"Dual PDE3\/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease.","volume":"157","author":"Banner","year":"2009","journal-title":"Br J Pharmacol"},{"key":"R49-10-20210129","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1465-9921-13-28","article-title":"Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts.","volume":"13","author":"Tannheimer","year":"2012","journal-title":"Respir Res"},{"key":"R50-10-20210129","first-page":"Cd003486","article-title":"Lung lavage for meconium aspiration syndrome in newborn infants.","volume":"4","author":"Hahn","year":"2013","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Journal of the Chinese Medical Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/JCMA.0000000000000063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T01:34:06Z","timestamp":1620956046000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/02118582-201907000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1097\/jcma.0000000000000063","relation":{},"ISSN":["1726-4901"],"issn-type":[{"value":"1726-4901","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}