{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:37:57Z","timestamp":1793644677399,"version":"4.5.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1097\/jcp.0b013e31823fe4bd","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T16:48:34Z","timestamp":1324745314000},"page":"120-126","source":"Crossref","is-referenced-by-count":45,"title":["A Randomized, Naturalistic, Parallel-Group Study for the Long-Term Treatment of Panic Disorder With Clonazepam or Paroxetine"],"prefix":"10.1097","volume":"32","author":[{"given":"Antonio E.","family":"Nardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael C.","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina D.","family":"Mochcovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Amrein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle N.","family":"Levitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre M.","family":"Valen\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 B.","family":"Veras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Sardinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valfrido L.","family":"de-Melo-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele P.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Cardoso de O.","family":"e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gast\u00e3o L.","family":"Soares-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael T.","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Mezzasalma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcele R.","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"de Cerqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E.","family":"Hallak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Crippa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Versiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20210128","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.euroneuro.2005.04.006","article-title":". The epidemiology of panic disorder and agoraphobia in Europe.","volume":"15","author":"Goodwin","year":"2005","journal-title":"Eur Neuropsychopharmacol"},{"key":"R2-20-20210128","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/archpsyc.63.4.415","article-title":". The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication.","volume":"63","author":"Kessler","year":"2006","journal-title":"Arch Gen Psychiatry"},{"issue":"suppl 4","key":"R3-20-20210128","first-page":"16","article-title":"Understanding and treating panic disorder in the primary care setting.","volume":"66","author":"Roy-Byrne","year":"2005","journal-title":"J Clin Psychiatry"},{"issue":"suppl 10","key":"R4-20-20210128","first-page":"44","article-title":"Clinical issues in the long-term treatment of panic disorder.","volume":"57","author":"Rosenbaum","year":"1996","journal-title":"J Clin Psychiatry"},{"issue":"suppl 2","key":"R5-20-20210128","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00004714-199812001-00003","article-title":"The long-term course of panic disorder and its predictors.","volume":"18","author":"Katschnig","year":"1998","journal-title":"J Clin Psychopharmacol"},{"issue":"suppl 8","key":"R6-20-20210128","first-page":"17","article-title":"The long-term treatment of panic disorder.","volume":"59","author":"Davidson","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"R7-20-20210128","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.eurpsy.2003.03.007","article-title":"A 15-year follow-up study of patients with panic disorder.","volume":"18","author":"Andersch","year":"2003","journal-title":"Eur Psychiatry"},{"key":"R9-20-20210128","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1600-0447.1997.tb00389.x","article-title":"Long-term evaluation of paroxetine, clomipramine and placebo in panic disorder. Collaborative Paroxetine Panic Study Investigators.","volume":"95","author":"Lecrubier","year":"1997","journal-title":"Acta Psychiatr Scand"},{"key":"R10-20-20210128","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1586\/14737175.4.2.191","article-title":". Paroxetine in panic disorder: clinical management and long-term follow-up.","volume":"4","author":"Dannon","year":"2004","journal-title":"Expert Rev Neurother"},{"key":"R11-20-20210128","first-page":"1432","article-title":"Goisman RM, et al..","volume":"160","author":"Bruce","year":"2003","journal-title":"Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia Am J Psychiatry"},{"key":"R12-20-20210128","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4088\/PCC.v07n0101","article-title":"The role of high-potency benzodiazepines in the treatment of panic disorder.","volume":"7","author":"Susman","year":"2005","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"R13-20-20210128","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/JCP.0b013e318210b4ee","article-title":". Randomized, open naturalistic acute treatment of panic disorder with clonazepam or paroxetine.","volume":"31","author":"Nardi","year":"2011","journal-title":"J Clin Psychopharmacol"},{"key":"R14-20-20210128","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1590\/S0004-282X2000000600008","article-title":". Double-blind clonazepam vs placebo in panic disorder treatment.","volume":"58","author":"Valenca","year":"2000","journal-title":"Arq Neuropsiquiatr"},{"key":"R15-20-20210128","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4088\/JCP.v60n0907","article-title":"Efficacy, safety, and gradual discontinuation of clonazepam in panic disorder: a placebo-controlled, multicenter study using optimized dosages.","volume":"60","author":"Moroz","year":"1999","journal-title":"J Clin Psychiatry"},{"key":"R16-20-20210128","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.psychres.2005.05.011","article-title":". A three-year follow-up study of patients with the respiratory subtype of panic disorder after treatment with clonazepam.","volume":"137","author":"Nardi","year":"2005","journal-title":"Psychiatry Res"},{"issue":"suppl 5","key":"R17-20-20210128","first-page":"7","article-title":"Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound.","volume":"65","author":"Chouinard","year":"2004","journal-title":"J Clin Psychiatry"},{"issue":"suppl 1","key":"R18-20-20210128","first-page":"53","article-title":"Treatment of panic disorder: focus on paroxetine.","volume":"37","author":"Pollack","year":"2003","journal-title":"Psychopharmacol Bull"},{"key":"R19-20-20210128","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jad.2005.05.003","article-title":"A meta-analysis of the efficacy of psycho- and pharmacotherapy in panic disorder with and without agoraphobia.","volume":"88","author":"Mitte","year":"2005","journal-title":"J Affect Disord"},{"key":"R21-20-20210128","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/01.yic.0000194377.88330.1d","article-title":". A double-blind, randomized, parallel-group, flexible-dose study to evaluate the tolerability, efficacy and effects of treatment discontinuation with escitalopram and paroxetine in patients with major depressive disorder.","volume":"21","author":"Baldwin","year":"2006","journal-title":"Int Clin Psychopharmacol"},{"key":"R22-20-20210128","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/JCP.0b013e3181dcb2f3","article-title":". Tapering clonazepam in patients with panic disorder after at least 3 years of treatment.","volume":"30","author":"Nardi","year":"2010","journal-title":"J Clin Psychopharmacol"},{"key":"R23-20-20210128","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-244X-4-16","article-title":". Three year naturalistic outcome study of panic disorder patients treated with paroxetine.","volume":"4","author":"Dannon","year":"2004","journal-title":"BMC Psychiatry"},{"key":"R24-20-20210128","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/NDT.S1557","article-title":"Pharmacological management of panic disorder.","volume":"4","author":"Marchesi","year":"2008","journal-title":"Neuropsychiatr Dis Treat"},{"key":"R25-20-20210128","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0031-6997(25)00468-5","article-title":"Benzodiazepines: use, abuse, and consequences.","volume":"44","author":"Woods","year":"1992","journal-title":"Pharmacol Rev"},{"key":"R26-20-20210128","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S0033291700007911","article-title":"Cognitive impairment in long-term benzodiazepine users.","volume":"18","author":"Golombok","year":"1998","journal-title":"Psychol Med"},{"key":"R27-20-20210128","first-page":"128","article-title":"The effect of anxiolytic drugs on memory in anxious subjects.","volume":"6","author":"Lucki","year":"1988","journal-title":"Psychopharmacol Ser"},{"key":"R28-20-20210128","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4088\/JCP.v61n0406","article-title":". Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxine.","volume":"61","author":"Kennedy","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"R29-20-20210128","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00003495-199855010-00007","article-title":"Paroxetine. An update of its pharmacology and therapeutic use in depression and a review of its use in other disorders.","volume":"55","author":"Gunasekara","year":"1998","journal-title":"Drugs"},{"key":"R30-20-20210128","first-page":"806","article-title":". An experimental study of tolerance to benzodiazepines in Romanian.","volume":"106","author":"Hriscu","year":"2002","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"R31-20-20210128","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1381612023396681","article-title":"Basic pharmacologic mechanisms involved in benzodiazepine tolerance and withdrawal.","volume":"8","author":"Bateson","year":"2002","journal-title":"Curr Pharm Des"}],"container-title":["Journal of Clinical Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00004714-201202000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T15:46:00Z","timestamp":1742139960000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00004714-201202000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/jcp.0b013e31823fe4bd","relation":{},"ISSN":["0271-0749"],"issn-type":[{"value":"0271-0749","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}