{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:47:42Z","timestamp":1778676462161,"version":"3.51.4"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1097\/jcp.0b013e31829798d5","type":"journal-article","created":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T13:53:03Z","timestamp":1376574783000},"page":"600-607","source":"Crossref","is-referenced-by-count":39,"title":["Efficacy and Tolerability of Risperidone, Yokukansan, and Fluvoxamine for the Treatment of Behavioral and Psychological Symptoms of Dementia"],"prefix":"10.1097","volume":"33","author":[{"given":"Mika","family":"Teranishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatake","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Takeyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Numata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amane","family":"Tateno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiro","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"suppl 1","key":"R1-3-20210128","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/(SICI)1099-1166(200004)15:1+<S2::AID-GPS159>3.0.CO;2-3","article-title":"Introduction to behavioural and psychological symptoms of dementia (BPSD).","volume":"15","author":"Finkel","year":"2000","journal-title":"Int J Geriatr Psychiatry"},{"issue":"7","key":"R2-3-20210128","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0929-6646(09)60150-9","article-title":"Behavioral and psychologic symptoms in different types of dementia.","volume":"105","author":"Chiu","year":"2006","journal-title":"J Formos Med Assoc"},{"issue":"2","key":"R3-3-20210128","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1212\/01.WNL.0000129990.32253.7B","article-title":"The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease.","volume":"63","author":"Holmes","year":"2004","journal-title":"Neurology"},{"issue":"14","key":"R4-3-20210128","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa066583","article-title":"Donepezil for the treatment of agitation in Alzheimers disease.","volume":"357","author":"Howard","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"R6-3-20210128","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1532-5415.1990.tb02407.x","article-title":"A metaanalysis of controlled trials of neuroleptic treatment in dementia.","volume":"38","author":"Schneider","year":"1990","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"R7-3-20210128","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4088\/JCP.v66n0214","article-title":"A randomized, observer-blind, controlled trial of the traditional Chinese medicine yi-gan san for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients.","volume":"66","author":"Iwasaki","year":"2005","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"R8-3-20210128","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1532-5415.2011.03373.x","article-title":"Open label trial to evaluate the efficacy and safety of yokukansan, a traditional Asian medicine, in dementia with Lewy bodies.","volume":"59","author":"Iwasaki","year":"2011","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"R9-3-20210128","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.pnpbp.2008.12.008","article-title":"Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimers disease.","volume":"33","author":"Monji","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"2","key":"R10-3-20210128","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S146114570800970X","article-title":"A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia.","volume":"12","author":"Mizukami","year":"2009","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"R11-3-20210128","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1176\/appi.ajp.159.3.460","article-title":"Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients.","volume":"159","author":"Pollock","year":"2002","journal-title":"Am J Psychiatry"},{"issue":"2","key":"R12-3-20210128","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5387\/fms.52.143","article-title":"Effects of fluvoxamine on behavioral and psychological symptoms of dementia in Alzheimers disease: a report of three cases.","volume":"52","author":"Kurita","year":"2006","journal-title":"Fukushima J Med Sci"},{"issue":"1","key":"R13-3-20210128","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-2003-814885","article-title":"State of the art management of BPSD in dementia.","volume":"32","author":"Rainer","year":"2005","journal-title":"Psychiatr Prax"},{"issue":"11","key":"R14-3-20210128","doi-asserted-by":"crossref","first-page":"894","DOI":"10.4088\/JCP.v62n1110","article-title":"Effect of risperidone on behavioral and psychological symptoms and cognitive function in dementia.","volume":"62","author":"Rainer","year":"2001","journal-title":"J Clin Psychiatry"},{"issue":"2","key":"R15-3-20210128","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4088\/JCP.v64n0205","article-title":"A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia.","volume":"64","author":"Brodaty","year":"2003","journal-title":"J Clin Psychiatry"},{"issue":"7","key":"R16-3-20210128","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimers disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimers Disease.","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"2","key":"R17-3-20210128","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop.","volume":"43","author":"Roman","year":"1993","journal-title":"Neurology"},{"issue":"5","key":"R18-3-20210128","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop.","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"issue":"3","key":"R19-3-20210128","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"1","key":"R20-3-20210128","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00019442-200002000-00010","article-title":"The use of the neuropsychiatric inventory in nursing home residents. Characterization and measurement.","volume":"8","author":"Wood","year":"2000","journal-title":"Am J Geriatr Psychiatry"},{"issue":"6","key":"R21-3-20210128","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.eurpsy.2007.03.001","article-title":"Quetiapine versus risperidone in elderly patients with behavioural and psychological symptoms of dementia: efficacy, safety and cognitive function.","volume":"22","author":"Rainer","year":"2007","journal-title":"Eur Psychiatry"},{"issue":"4","key":"R22-3-20210128","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2165\/00003495-198632040-00002","article-title":"Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.","volume":"32","author":"Benfield","year":"1986","journal-title":"Drugs"},{"issue":"6","key":"R23-3-20210128","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1600-0447.1991.tb05579.x","article-title":"Double-blind comparative multicentre study of fluvoxamine and mianserin in the treatment of major depressive episode in elderly people.","volume":"83","author":"Phanjoo","year":"1991","journal-title":"Acta Psychiatr Scand"},{"issue":"12","key":"R24-3-20210128","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia.","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"issue":"1","key":"R26-3-20210128","first-page":"39","article-title":"Extrapyramidal symptom profiles assessed with the Drug-Induced Extrapyramidal Symptom Scale: comparison with Western scales in the clinical double-blind studies of schizophrenic patients treated with either olanzapine or haloperidol.","volume":"18","author":"Inada","year":"2003","journal-title":"Int Clin Psychopharmacol"},{"issue":"1","key":"R27-3-20210128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1592\/phco.22.1.1.33496","article-title":"Comparison of risperidone with olanzapine in elderly patients with dementia and psychosis.","volume":"22","author":"Ellingrod","year":"2002","journal-title":"Pharmacotherapy"},{"issue":"3","key":"R28-3-20210128","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/01.JGP.0000200589.01396.6d","article-title":"Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials.","volume":"14","author":"Schneider","year":"2006","journal-title":"Am J Geriatr Psychiatry"},{"issue":"15","key":"R30-3-20210128","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.294.15.1934","article-title":"Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials.","volume":"294","author":"Schneider","year":"2005","journal-title":"JAMA"},{"issue":"1","key":"R32-3-20210128","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1176\/appi.ajp.2011.11030347","article-title":"Risk of mortality among individual antipsychotics in patients with dementia.","volume":"169","author":"Kales","year":"2012","journal-title":"Am J Psychiatry"},{"issue":"11","key":"R33-3-20210128","first-page":"1269","article-title":"Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials.","volume":"167","author":"Wooltorton","year":"2002","journal-title":"Cmaj"},{"issue":"8","key":"R34-3-20210128","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1176\/ajp.147.8.1049","article-title":"Psychiatric symptoms and nursing home placement of patients with Alzheimers disease.","volume":"147","author":"Steele","year":"1990","journal-title":"Am J Psychiatry"},{"issue":"1","key":"R35-3-20210128","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1179\/147683008X301414","article-title":"Suppressive effect of yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats.","volume":"11","author":"Takeda","year":"2008","journal-title":"Nutr Neurosci"},{"issue":"4","key":"R36-3-20210128","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.neuroscience.2009.02.004","article-title":"Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells.","volume":"159","author":"Kawakami","year":"2009","journal-title":"Neuroscience"},{"key":"R37-3-20210128","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1744-859X-9-6","article-title":"Sigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimers disease.","volume":"9","author":"Furuse","year":"2010","journal-title":"Ann Gen Psychiatry"},{"issue":"3","key":"R38-3-20210128","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/1871524910909030197","article-title":"Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship.","volume":"9","author":"Hashimoto","year":"2009","journal-title":"Cent Nerv Syst Agents Med Chem"},{"issue":"7","key":"R39-3-20210128","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2174\/138161212799436476","article-title":"Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases.","volume":"18","author":"Niitsu","year":"2012","journal-title":"Curr Pharm Des"}],"container-title":["Journal of Clinical Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/JCP.0b013e31829798d5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T02:01:50Z","timestamp":1620957710000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00004714-201310000-00003"}},"subtitle":["A Blinded, Randomized Trial"],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/jcp.0b013e31829798d5","relation":{},"ISSN":["0271-0749"],"issn-type":[{"value":"0271-0749","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}