{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:22:58Z","timestamp":1789424578635,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1097\/jgp.0b013e318196a632","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T13:19:16Z","timestamp":1234963156000},"page":"196-209","source":"Crossref","is-referenced-by-count":44,"title":["Modeling Brain Reserve: Experience-Dependent Neuronal Plasticity in Healthy and Huntington's Disease Transgenic Mice"],"prefix":"10.1016","volume":"17","author":[{"given":"Jess","family":"Nithianantharajah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Barkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirosen","family":"Vijiaratnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/JGP.0b013e318196a632_bib1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1023\/A:1013353613591","article-title":"Genetic structure of spatial and verbal working memory","volume":"31","author":"Ando","year":"2001","journal-title":"Behav Genet"},{"key":"10.1097\/JGP.0b013e318196a632_bib2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/archneur.60.3.359","article-title":"Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis","volume":"60","author":"Scarmeas","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1076\/jcen.25.5.625.14576","article-title":"Cognitive reserve and lifestyle","volume":"25","author":"Scarmeas","year":"2003","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1097\/JGP.0b013e318196a632_bib4","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1001\/jama.288.18.2271","article-title":"Effects of cognitive training interventions with older adults: a randomized controlled trial","volume":"288","author":"Ball","year":"2002","journal-title":"JAMA"},{"key":"10.1097\/JGP.0b013e318196a632_bib5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington's in mice","volume":"404","author":"van Dellen","year":"2000","journal-title":"Nature"},{"key":"10.1097\/JGP.0b013e318196a632_bib7","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1523\/JNEUROSCI.1658-03.2004","article-title":"Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism","volume":"24","author":"Spires","year":"2004","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib8","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.nbd.2007.11.006","article-title":"Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice","volume":"29","author":"Nithianantharajah","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1097\/JGP.0b013e318196a632_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ana.10094","article-title":"Environmental enrichment slows disease progression in R6\/2 Huntington's disease mice","volume":"51","author":"Hockly","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib10","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset","volume":"101","author":"Wexler","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/JGP.0b013e318196a632_bib11","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1136\/jnnp.74.7.968","article-title":"Genetically confirmed clinical Huntington's disease with no observable cell loss","volume":"74","author":"Caramins","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1097\/JGP.0b013e318196a632_bib12","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1073\/pnas.110078997","article-title":"Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease","volume":"97","author":"Turmaine","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/JGP.0b013e318196a632_bib13","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"10.1097\/JGP.0b013e318196a632_bib14","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1523\/JNEUROSCI.11-12-03877.1991","article-title":"Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry","volume":"11","author":"Ferrante","year":"1991","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib15","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1111\/j.0953-816X.2004.03374.x","article-title":"Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6\/1 Huntington's disease transgenic mice","volume":"19","author":"Spires","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib16","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","article-title":"Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington's disease transgenic mice","volume":"86","author":"Klapstein","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1097\/JGP.0b013e318196a632_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/exnr.2000.7626","article-title":"Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production","volume":"169","author":"Guidetti","year":"2001","journal-title":"Exp Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib18","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/hmg\/8.5.839","article-title":"Impaired synaptic plasticity in mice carrying the Huntington's disease mutation","volume":"8","author":"Usdin","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1097\/JGP.0b013e318196a632_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","article-title":"A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration","volume":"23","author":"Hodgson","year":"1999","journal-title":"Neuron"},{"key":"10.1097\/JGP.0b013e318196a632_bib20","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1523\/JNEUROSCI.20-13-05115.2000","article-title":"Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation","volume":"20","author":"Murphy","year":"2000","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1523\/JNEUROSCI.23-03-00961.2003","article-title":"Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease","volume":"23","author":"Cepeda","year":"2003","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib22","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1111\/j.1460-9568.2005.04349.x","article-title":"A similar impairment in CA3 mossy fibre LTP in the R6\/2 mouse model of Huntington's disease and in the complexin II knockout mouse","volume":"22","author":"Gibson","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib23","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/hmg\/ddl092","article-title":"Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease","volume":"15","author":"Milnerwood","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1097\/JGP.0b013e318196a632_bib24","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1093\/hmg\/ddl224","article-title":"Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease","volume":"15","author":"Cummings","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1097\/JGP.0b013e318196a632_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1097\/JGP.0b013e318196a632_bib26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","article-title":"Differential effects of voluntary physical exercise on al and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice","volume":"141","author":"Pang","year":"2006","journal-title":"Neuroscience"},{"key":"10.1097\/JGP.0b013e318196a632_bib27","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1097\/JGP.0b013e318196a632_bib28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/72945","article-title":"Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice","volume":"3","author":"Rampon","year":"2000","journal-title":"Nat Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib29","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1523\/JNEUROSCI.4320-04.2005","article-title":"Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice","volume":"25","author":"Mazarakis","year":"2005","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddn385","article-title":"Altered serotonin receptor expression is associated with depression-related behavior in the R6\/1 transgenic mouse model of Huntington's disease","author":"Pang","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1097\/JGP.0b013e318196a632_bib31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0014-4886(73)90090-3","article-title":"Pattern of dendritic branching in occipital cortex of rats reared in complex environments","volume":"40","author":"Greenough","year":"1973","journal-title":"Exp Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0014-4886(73)90278-1","article-title":"Effects of rearing complexity on dendritic branching in frontolateral and temporal cortex of the rat","volume":"41","author":"Greenough","year":"1973","journal-title":"Exp Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib33","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1073\/pnas.82.13.4549","article-title":"Evidence for active synapse formation or altered postsynaptic metabolism in visual cortex of rats reared in complex environments","volume":"82","author":"Greenough","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/JGP.0b013e318196a632_bib34","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0014-4886(82)90064-4","article-title":"Increased length of terminal dendritic segments in old adult rats' somatosensory cortex: an environmentally induced response","volume":"78","author":"Connor","year":"1982","journal-title":"Exp Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(85)90525-6","article-title":"Differential rearing effects on rat visual cortex synapses. I Synaptic and neuronal density and synapses per neuron","volume":"329","author":"Turner","year":"1985","journal-title":"Brain Res"},{"key":"10.1097\/JGP.0b013e318196a632_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-3806(02)00642-9","article-title":"A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment","volume":"141","author":"Faherty","year":"2003","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1097\/JGP.0b013e318196a632_bib37","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2005.04.009","article-title":"Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat","volume":"163","author":"Leggio","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1097\/JGP.0b013e318196a632_bib38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"key":"10.1097\/JGP.0b013e318196a632_bib39","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1523\/JNEUROSCI.18-09-03206.1998","article-title":"Experience-induced neurogenesis in the senescent dentate gyrus","volume":"18","author":"Kempermann","year":"1998","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0960-9822(07)00377-6","article-title":"Environmental stimulation of 129\/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus","volume":"8","author":"Kempermann","year":"1998","journal-title":"Curr Biol"},{"key":"10.1097\/JGP.0b013e318196a632_bib41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat Rev Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ana.10262","article-title":"Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment","volume":"52","author":"Kempermann","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib43","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1460-9568.2005.03875.x","article-title":"New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment","volume":"21","author":"Bruel-Jungerman","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib44","doi-asserted-by":"crossref","first-page":"12880","DOI":"10.1073\/pnas.97.23.12880","article-title":"Effects of environmental enrichment on gene expression in the brain","volume":"97","author":"Rampon","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/JGP.0b013e318196a632_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/exnr.2000.7415","article-title":"Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain","volume":"164","author":"Ickes","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1097\/JGP.0b013e318196a632_bib46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/jn.1986.55.4.739","article-title":"Altered synaptic transmission in dentate gyrus of rats reared in complex environments: evidence from hippocampal slices maintained in vitro","volume":"55","author":"Green","year":"1986","journal-title":"J Neurophysiol"},{"key":"10.1097\/JGP.0b013e318196a632_bib47","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0006-8993(96)00707-X","article-title":"Mechanism of altered synaptic strength due to experience: relation to long-term potentiation","volume":"736","author":"Foster","year":"1996","journal-title":"Brain Res"},{"key":"10.1097\/JGP.0b013e318196a632_bib48","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1152\/jn.2001.85.4.1377","article-title":"Mechanism for increased hippocampal synaptic strength following differential experience","volume":"85","author":"Foster","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1097\/JGP.0b013e318196a632_bib49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1101\/lm.36301","article-title":"Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory","volume":"8","author":"Duffy","year":"2001","journal-title":"Learn Mem"},{"key":"10.1097\/JGP.0b013e318196a632_bib50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1460-9568.2005.04552.x","article-title":"Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioral stress and environmental enrichment","volume":"23","author":"Artola","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2006.09.017","article-title":"Factors critical for the plasticity of dendritic spines and memory storage","volume":"57","author":"Matsuzaki","year":"2007","journal-title":"Neurosci Res"},{"key":"10.1097\/JGP.0b013e318196a632_bib52","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1111\/j.1460-9568.2006.05182.x","article-title":"Morphological and cellular changes within embryonic striatal grafts associated with enriched environment and involuntary exercise","volume":"24","author":"Dobrossy","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib53","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/jnnp.2002.002576","article-title":"Fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease is qualitatively distinct","volume":"75","author":"Bradshaw","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1097\/JGP.0b013e318196a632_bib54","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases","volume":"443","author":"Palop","year":"2006","journal-title":"Nature"},{"key":"10.1097\/JGP.0b013e318196a632_bib55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature05772","article-title":"Recovery of learning and memory is associated with chromatin remodelling","volume":"447","author":"Fischer","year":"2007","journal-title":"Nature"},{"key":"10.1097\/JGP.0b013e318196a632_bib56","doi-asserted-by":"crossref","first-page":"11557","DOI":"10.1073\/pnas.0504984102","article-title":"Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile \u00d7 syndrome","volume":"102","author":"Restivo","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/JGP.0b013e318196a632_bib57","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1523\/JNEUROSCI.5080-04.2005","article-title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease","volume":"25","author":"Jankowsky","year":"2005","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318196a632_bib58","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/sj.mp.4002046","article-title":"Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration","volume":"13","author":"McOmish","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1097\/JGP.0b013e318196a632_bib59","first-page":"351","article-title":"Huntington's disease: which drugs might help patients?","volume":"7","author":"Hannan","year":"2004","journal-title":"IDrugs"},{"key":"10.1097\/JGP.0b013e318196a632_bib60","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1517\/14728222.9.4.639","article-title":"Novel therapeutic targets for Huntington's disease","volume":"9","author":"Hannan","year":"2005","journal-title":"Expert Opin Ther Targets"},{"key":"10.1097\/JGP.0b013e318196a632_bib61","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1517\/14728222.11.7.899","article-title":"Enviromimetics: exploring gene environment interactions to identify therapeutic targets for brain disorders","volume":"11","author":"McOmish","year":"2007","journal-title":"Expert Opin Ther Targets"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112616005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112616005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T03:36:40Z","timestamp":1558150600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748112616005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S1064748112616005"],"URL":"https:\/\/doi.org\/10.1097\/jgp.0b013e318196a632","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}