{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:52:06Z","timestamp":1790545926192,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1097\/jgp.0b013e318209ddf1","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T06:55:39Z","timestamp":1295333739000},"page":"618-626","source":"Crossref","is-referenced-by-count":17,"title":["Brain Biochemical Correlates of the Plasma Homocysteine Level: A Proton Magnetic Resonance Spectroscopy Study in the Elderly Subjects"],"prefix":"10.1016","volume":"19","author":[{"given":"Cheng-Sheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yi","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Fang","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Fen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suh-Hang Hank","family":"Juo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin-Chung","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/JGP.0b013e318209ddf1_bib1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archpsyc.60.6.618","article-title":"Folate, vitamin B12, homocysteine, and the MTHFR 677C\u2192T polymorphism in anxiety and depression: the Hordaland Homocysteine Study","volume":"60","author":"Bjelland","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00019442-200510000-00006","article-title":"Homocysteine levels, MTHFR C677T genotype, and MRI hyperintensities in late-onset major depressive disorder","volume":"13","author":"Chen","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib4","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcn\/63.3.306","article-title":"Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study","volume":"63","author":"Riggs","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ana.10440","article-title":"Homocysteine, white matter hyperintensities, and cognition in healthy elderly people","volume":"53","author":"Dufouil","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ajcn\/75.5.908","article-title":"Homocysteine, B vitamin status, and cognitive function in the elderly","volume":"75","author":"Duthie","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/ajcn\/73.5.927","article-title":"Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey","volume":"73","author":"Morris","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1532-5415.2005.53153.x","article-title":"Homocysteine and cognitive function in a population-based study of older adults","volume":"53","author":"Schafer","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000051275","article-title":"Homocysteine and cognitive decline in healthy elderly","volume":"12","author":"McCaddon","year":"2001","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib10","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1212\/01.WNL.0000032494.05619.93","article-title":"Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study","volume":"59","author":"Prins","year":"2002","journal-title":"Neurology"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib11","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1212\/01.WNL.0000158476.74580.A8","article-title":"Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment","volume":"64","author":"Boxer","year":"2005","journal-title":"Neurology"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.psy.0000221380.92521.51","article-title":"Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study","volume":"68","author":"Elias","year":"2006","journal-title":"Psychosom Med"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jns.2004.09.006","article-title":"Homocysteine, cerebrovascular disease and brain atrophy","volume":"226","author":"Sachdev","year":"2004","journal-title":"J Neurol Sci"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/brain\/awg006","article-title":"Homocysteine and brain atrophy on MRI of non-demented elderly","volume":"126","author":"den Heijer","year":"2003","journal-title":"Brain"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib15","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1176\/appi.ajp.159.12.2096","article-title":"Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression","volume":"159","author":"Naismith","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib16","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/archneur.65.5.642","article-title":"Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study","volume":"65","author":"Seshadri","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1056\/NEJM200202143460702","article-title":"Homocysteine and dementias","volume":"346","author":"Loscalzo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.atherosclerosis.2004.01.005","article-title":"Elevated levels of plasma homocysteine are associated with neurotoxicity","volume":"174","author":"Bisschops","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1079\/BJN2001479","article-title":"Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of young people aged 4\u201318 years, and a comparison with the survey of people aged 65 years and over","volume":"87","author":"Bates","year":"2002","journal-title":"Br J Nutr"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib20","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/ajcn\/64.4.587","article-title":"Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits","volume":"64","author":"Lussier-Cacan","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib21","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/aje\/152.2.140","article-title":"Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey","volume":"152","author":"Morris","year":"2000","journal-title":"Am J Epidemiol"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib22","first-page":"59","article-title":"Elevation of plasma homocysteine in natural menopause can not be explained by a lack of vitamin coenzyme availability: relevance to the risk of cardiovascular disease","volume":"9","author":"Masse","year":"2005","journal-title":"J Nutr Health Aging"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archpsyc.1996.01830070031007","article-title":"Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging","volume":"53","author":"Murphy","year":"1996","journal-title":"Arch Gen Psychiatry"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","article-title":"Development of a rating scale for primary depressive illness","volume":"6","author":"Hamilton","year":"1967","journal-title":"Br J Soc Clin Psychol"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib26","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.290.8.1049","article-title":"A risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study","volume":"290","author":"Wang","year":"2003","journal-title":"JAMA"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0925-4927(01)00102-0","article-title":"Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophrenia","volume":"107","author":"Bustillo","year":"2001","journal-title":"Psychiatry Res"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0730-725X(96)00334-7","article-title":"Cerebral volumes and spectroscopic proton metabolites on MR: is sex important?","volume":"15","author":"Wilkinson","year":"1997","journal-title":"Magn Reson Imaging"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1522-2594(199907)42:1<24::AID-MRM5>3.0.CO;2-3","article-title":"1H chemical shift imaging of the human brain at age 60\u201390 years reveals metabolic differences between women and men","volume":"42","author":"Sijens","year":"1999","journal-title":"Magn Reson Med"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib30","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1080\/10641960802563576","article-title":"Effect of choline-containing phospholipids on transglutaminase activity in primary astroglial cell cultures","volume":"30","author":"Bramanti","year":"2008","journal-title":"Clin Exp Hypertens"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.pscychresns.2009.01.003","article-title":"Proton magnetic resonance spectroscopy of late-life major depressive disorder","volume":"172","author":"Chen","year":"2009","journal-title":"Psychiatry Res"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2005.12.004","article-title":"Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis","volume":"147","author":"Yildiz-Yesiloglu","year":"2006","journal-title":"Psychiatry Res"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.brainresbull.2008.02.035","article-title":"Functions and effects of creatine in the central nervous system","volume":"76","author":"Andres","year":"2008","journal-title":"Brain Res Bull"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib34","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<866::AID-JNR12>3.0.CO;2-K","article-title":"Effect of osmolality and anion channel inhibitors on myo-inositol efflux in cultured astrocytes","volume":"57","author":"Isaacks","year":"1999","journal-title":"J Neurosci Res"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0022-3956(95)00005-P","article-title":"Possible acceleration of age effects on cognition following menopause","volume":"29","author":"Halbreich","year":"1995","journal-title":"J Psychiatr Res"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib36","first-page":"67","article-title":"Estrogen effects on the hippocampus and frontal lobes","volume":"50","author":"Maki","year":"2005","journal-title":"Int J Fertil Womens Med"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0197-4580(97)00056-0","article-title":"Frequency of stages of Alzheimer-related lesions in different age categories","volume":"18","author":"Braak","year":"1997","journal-title":"Neurobiol Aging"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib38","first-page":"117","article-title":"Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture","volume":"216","author":"Kim","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib39","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","article-title":"Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity","volume":"20","author":"Kruman","year":"2000","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib40","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1212\/01.wnl.0000183063.99107.5c","article-title":"Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease","volume":"65","author":"Irizarry","year":"2005","journal-title":"Neurology"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1471-4159.2001.00384.x","article-title":"Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress","volume":"78","author":"Ho","year":"2001","journal-title":"J Neurochem"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib42","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1523\/JNEUROSCI.22-05-01752.2002","article-title":"Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease","volume":"22","author":"Kruman","year":"2002","journal-title":"J Neurosci"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib43","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.febslet.2006.04.088","article-title":"Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia","volume":"580","author":"Obeid","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1097\/JGP.0b013e318209ddf1_bib44","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.neurobiolaging.2007.04.015","article-title":"Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus","volume":"29","author":"Zhang","year":"2008","journal-title":"Neurobiol Aging"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112600359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112600359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T23:04:52Z","timestamp":1559948692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748112600359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S1064748112600359"],"URL":"https:\/\/doi.org\/10.1097\/jgp.0b013e318209ddf1","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}