{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:36:53Z","timestamp":1793929013207,"version":"4.8.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1097\/jgp.0b013e3182423b6a","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T14:13:56Z","timestamp":1330524836000},"page":"603-611","source":"Crossref","is-referenced-by-count":15,"title":["The Polymorphism of the ATP-Binding Cassette Transporter 1 Gene Modulates Alzheimer Disease Risk in Chinese Han Ethnic Population"],"prefix":"10.1016","volume":"20","author":[{"given":"Yi-Min","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Hao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Zhen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/JGP.0b013e3182423b6a_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2377-8-9","article-title":"APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway","volume":"8","author":"Sando","year":"2008","journal-title":"BMC Neurol"},{"issue":"10","key":"10.1097\/JGP.0b013e3182423b6a_bib2","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrn2494","article-title":"Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses","volume":"9","author":"Bertram","year":"2008","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"10.1097\/JGP.0b013e3182423b6a_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/psc.1207","article-title":"Interaction of a beta-sheet breaker peptide with lipid membranes","volume":"16","author":"Vitiello","year":"2010","journal-title":"J Pept Sci"},{"issue":"5","key":"10.1097\/JGP.0b013e3182423b6a_bib4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10863-009-9242-6","article-title":"Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease","volume":"41","author":"Colell","year":"2009","journal-title":"J Bioenerg Biomembr"},{"issue":"2","key":"10.1097\/JGP.0b013e3182423b6a_bib5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.plipres.2009.10.004","article-title":"Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk","volume":"49","author":"Takechi","year":"2010","journal-title":"Prog Lipid Res"},{"issue":"2","key":"10.1097\/JGP.0b013e3182423b6a_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/156720507780362119","article-title":"Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver","volume":"4","author":"Sparks","year":"2007","journal-title":"Curr Alzheimer Res"},{"issue":"Suppl 2","key":"10.1097\/JGP.0b013e3182423b6a_bib7","first-page":"130","article-title":"Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis","volume":"36","author":"McLaurin","year":"2003","journal-title":"Pharmacopsychiatry"},{"issue":"6","key":"10.1097\/JGP.0b013e3182423b6a_bib8","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1471-4159.2009.06408.x","article-title":"Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease","volume":"111","author":"Martins","year":"2009","journal-title":"J Neurochem"},{"issue":"1","key":"10.1097\/JGP.0b013e3182423b6a_bib9","doi-asserted-by":"crossref","first-page":"e8556","DOI":"10.1371\/journal.pone.0008556","article-title":"LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease","volume":"5","author":"Abisambra","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1097\/JGP.0b013e3182423b6a_bib10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/WAD.0b013e3181a80242","article-title":"On cholesterol levels and statins in cognitive decline and Alzheimer disease: progress and setbacks","volume":"23","author":"Sabbagh","year":"2009","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"2","key":"10.1097\/JGP.0b013e3182423b6a_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.expneurol.2009.09.013","article-title":"Cholesterol and statins in Alzheimer's disease: current controversies","volume":"223","author":"Fonseca","year":"2010","journal-title":"Exp Neurol"},{"issue":"5","key":"10.1097\/JGP.0b013e3182423b6a_bib12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0006-2952(02)01654-4","article-title":"Statin effects on cholesterol micro-domains in brain plasma membranes","volume":"65","author":"Kirsch","year":"2003","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"10.1097\/JGP.0b013e3182423b6a_bib13","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0022-2275(20)31566-2","article-title":"ABCA1. The gatekeeper for eliminating excess tissue cholesterol","volume":"42","author":"Oram","year":"2001","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1097\/JGP.0b013e3182423b6a_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/hmg\/ddg007","article-title":"Results of a high-resolution genome screen of 437 Alzheimer's disease families","volume":"12","author":"Blacker","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"9\u201310","key":"10.1097\/JGP.0b013e3182423b6a_bib15","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0531-5565(00)00196-0","article-title":"Identification of novel genes in late-onset Alzheimer's disease","volume":"35","author":"Pericak-Vance","year":"2000","journal-title":"Exp Gerontol"},{"issue":"3","key":"10.1097\/JGP.0b013e3182423b6a_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/biof.37","article-title":"Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E","volume":"35","author":"Fan","year":"2009","journal-title":"Biofactors"},{"issue":"1\u20132","key":"10.1097\/JGP.0b013e3182423b6a_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11010-008-0012-2","article-title":"Why lipids are important for Alzheimer disease?","volume":"326","author":"Hirsch-Reinshagen","year":"2009","journal-title":"Mol Cell Biochem"},{"issue":"39","key":"10.1097\/JGP.0b013e3182423b6a_bib18","doi-asserted-by":"crossref","first-page":"40987","DOI":"10.1074\/jbc.M407963200","article-title":"ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE","volume":"279","author":"Wahrle","year":"2004","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1097\/JGP.0b013e3182423b6a_bib19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.neulet.2004.05.047","article-title":"Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study","volume":"366","author":"Li","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1097\/JGP.0b013e3182423b6a_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2007.02.005","article-title":"Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese","volume":"1147","author":"Wang","year":"2007","journal-title":"Brain Res"},{"issue":"2","key":"10.1097\/JGP.0b013e3182423b6a_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1399-0004.2007.00940.x","article-title":"Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels","volume":"73","author":"Slatter","year":"2008","journal-title":"Clin Genet"},{"issue":"2","key":"10.1097\/JGP.0b013e3182423b6a_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00439-003-0943-3","article-title":"ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore","volume":"113","author":"Tan","year":"2003","journal-title":"Hum Genet"},{"issue":"4","key":"10.1097\/JGP.0b013e3182423b6a_bib23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neurobiolaging.2008.05.032","article-title":"The R219K polymorphism in the ATP-binding cassette transporter 1 gene has a protective effect on atherothrombotic cerebral infarction in Chinese Han ethnic population","volume":"31","author":"Wang","year":"2010","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.1097\/JGP.0b013e3182423b6a_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/clinchem\/45.1.143","article-title":"Rapid identification of apolipoprotein E genotypes by multiplex amplification refractory mutation system PCR and capillary gel electrophoresis","volume":"45","author":"Donohoe","year":"1999","journal-title":"Clin Chem"},{"issue":"9","key":"10.1097\/JGP.0b013e3182423b6a_bib25","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI200420361","article-title":"Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population","volume":"114","author":"Frikke-Schmidt","year":"2004","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1097\/JGP.0b013e3182423b6a_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/humu.20012","article-title":"Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism","volume":"23","author":"Katzov","year":"2004","journal-title":"Hum Mutat"},{"issue":"9","key":"10.1097\/JGP.0b013e3182423b6a_bib27","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/01.CIR.103.9.1198","article-title":"Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease","volume":"103","author":"Clee","year":"2001","journal-title":"Circulation"},{"issue":"3","key":"10.1097\/JGP.0b013e3182423b6a_bib28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0021-9150(00)00722-X","article-title":"Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease","volume":"154","author":"Brousseau","year":"2001","journal-title":"Atherosclerosis"},{"issue":"12","key":"10.1097\/JGP.0b013e3182423b6a_bib29","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/hmg\/ddm091","article-title":"Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients","volume":"16","author":"Kyriakou","year":"2007","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1097\/JGP.0b013e3182423b6a_bib30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00109-003-0426-y","article-title":"The association of the R219K polymorphism in the ATP-binding cassette transporter 1 (ABCA1) gene with coronary heart disease and hyperlipidemia","volume":"81","author":"Evans","year":"2003","journal-title":"J Mol Med"},{"issue":"7","key":"10.1097\/JGP.0b013e3182423b6a_bib31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/ajmg.b.30552","article-title":"Association of genetic variants of ABCA1 with Alzheimer's disease risk","volume":"144B","author":"Rodr\u00edguez-Rodr\u00edguez","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"6","key":"10.1097\/JGP.0b013e3182423b6a_bib32","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.neurobiolaging.2006.04.005","article-title":"Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease","volume":"28","author":"Sundar","year":"2007","journal-title":"Neurobiol Aging"},{"issue":"5","key":"10.1097\/JGP.0b013e3182423b6a_bib33","first-page":"791","article-title":"Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease","volume":"17","author":"K\u00f6lsch","year":"2006","journal-title":"Int J Mol Med"},{"key":"10.1097\/JGP.0b013e3182423b6a_bib34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-1326-2-7","article-title":"Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms","volume":"2","author":"Wahrle","year":"2007","journal-title":"Mol Neurodegener"},{"issue":"3","key":"10.1097\/JGP.0b013e3182423b6a_bib35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neulet.2005.08.048","article-title":"Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease","volume":"391","author":"Shibata","year":"2006","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1097\/JGP.0b013e3182423b6a_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0197-4580(02)00094-5","article-title":"ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease","volume":"24","author":"Wollmer","year":"2004","journal-title":"Neurobiol Aging"},{"issue":"12","key":"10.1097\/JGP.0b013e3182423b6a_bib37","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1001\/archneur.61.12.1930","article-title":"APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study","volume":"61","author":"Huang","year":"2004","journal-title":"Arch Neurol"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112620867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112620867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T21:35:55Z","timestamp":1640986555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748112620867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S1064748112620867"],"URL":"https:\/\/doi.org\/10.1097\/jgp.0b013e3182423b6a","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}