{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:47:31Z","timestamp":1790596051477,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1097\/jgp.0b013e31824361de","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T09:15:50Z","timestamp":1328865350000},"page":"744-752","source":"Crossref","is-referenced-by-count":47,"title":["Sleep Disturbance and Older Adults' Inflammatory Responses to Acute Stress"],"prefix":"10.1016","volume":"20","author":[{"given":"Kathi L.","family":"Heffner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Mei","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Suhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"France","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gailen D.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfred R.","family":"Pigeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.","family":"Moynihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 2","key":"10.1097\/JGP.0b013e31824361de_bib1","first-page":"S379","article-title":"Quality of life in people with insomnia","volume":"22","author":"Zammit","year":"1999","journal-title":"Sleep"},{"key":"10.1097\/JGP.0b013e31824361de_bib2","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/jama.1989.03430110069030","article-title":"Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?","volume":"262","author":"Ford","year":"1989","journal-title":"JAMA"},{"key":"10.1097\/JGP.0b013e31824361de_bib3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archinte.158.10.1099","article-title":"Clinical correlates of insomnia in patients with chronic illness","volume":"158","author":"Katz","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0889-1591(02)00003-X","article-title":"Effects of sleep and sleep loss on immunity and cytokines","volume":"16","author":"Irwin","year":"2002","journal-title":"Brain Behav Immun"},{"key":"10.1097\/JGP.0b013e31824361de_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.2001.tb05826.x","article-title":"The role of cytokines in physiological sleep regulation","volume":"933","author":"Krueger","year":"2001","journal-title":"Ann NY Acad Sci"},{"key":"10.1097\/JGP.0b013e31824361de_bib6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1053\/meta.2002.33357","article-title":"Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime","volume":"51","author":"Vgontzas","year":"2002","journal-title":"Metabolism"},{"key":"10.1097\/JGP.0b013e31824361de_bib7","doi-asserted-by":"crossref","first-page":"18757","DOI":"10.1073\/pnas.0509281102","article-title":"Social relationships, sleep quality, and interleukin-6 in aging women","volume":"102","author":"Friedman","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1097\/JGP.0b013e31824361de_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/AJP.0b013e3181eef761","article-title":"Chronic low back pain, sleep disturbance, and interleukin-6","volume":"27","author":"Heffner","year":"2011","journal-title":"Clin J Pain"},{"key":"10.1097\/JGP.0b013e31824361de_bib9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.psy.0000221371.43607.64","article-title":"Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study","volume":"68","author":"McDade","year":"2006","journal-title":"Psychosom Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib10","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.bbi.2008.01.011","article-title":"Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity","volume":"22","author":"Suarez","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1097\/JGP.0b013e31824361de_bib11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/PSY.0b013e3182020d08","article-title":"Sleep variability, health-related practices, and inflammatory markers in a community dwelling sample of older adults","volume":"73","author":"Okun","year":"2011","journal-title":"Psychosom Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1037\/0033-2909.130.4.601","article-title":"Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry","volume":"130","author":"Segerstrom","year":"2004","journal-title":"Psychol Bull"},{"key":"10.1097\/JGP.0b013e31824361de_bib13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1037\/0278-6133.26.4.447","article-title":"Differentiating the impact of episodic and chronic stressors on hypothalamic\u2013pituitary\u2013adrenocortical axis regulation in young women","volume":"26","author":"Marin","year":"2007","journal-title":"Health Psychol"},{"key":"10.1097\/JGP.0b013e31824361de_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1037\/0278-6133.20.6.403","article-title":"Chronic stress influences cardiovascular and neuroendocrine responses during acute stress and recovery, especially in men","volume":"20","author":"Matthews","year":"2001","journal-title":"Health Psychol"},{"key":"10.1097\/JGP.0b013e31824361de_bib15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1037\/0278-6133.21.6.531","article-title":"Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model","volume":"21","author":"Miller","year":"2002","journal-title":"Health Psychol"},{"key":"10.1097\/JGP.0b013e31824361de_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbi.2003.09.011","article-title":"Socioeconomic status and stress-induced increases in interleukin-6","volume":"18","author":"Brydon","year":"2004","journal-title":"Brain Behav Immun"},{"key":"10.1097\/JGP.0b013e31824361de_bib17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.smrv.2007.07.007","article-title":"Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity","volume":"12","author":"Meerlo","year":"2008","journal-title":"Sleep Med Rev"},{"key":"10.1097\/JGP.0b013e31824361de_bib18","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/AJP.0b013e3181c328e9","article-title":"Negative mood mediates the effect of poor sleep on pain among chronic pain patients","volume":"26","author":"O'Brien","year":"2010","journal-title":"Clin J Pain"},{"key":"10.1097\/JGP.0b013e31824361de_bib19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/01.PSY.0000097338.75454.29","article-title":"Immunological effects of induced shame and guilt","volume":"66","author":"Dickerson","year":"2004","journal-title":"Psychosom Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12160-009-9100-0","article-title":"Individual differences in executive functioning: implications for stress regulation","volume":"37","author":"Williams","year":"2009","journal-title":"Ann Behav Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib21","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1055\/s-0029-1237117","article-title":"Neurocognitive consequences of sleep deprivation","volume":"29","author":"Goel","year":"2009","journal-title":"Semin Neurol"},{"key":"10.1097\/JGP.0b013e31824361de_bib22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/10673220802432210","article-title":"Sleep in the elderly: normal variations and common sleep disorders","volume":"16","author":"Ancoli-Israel","year":"2008","journal-title":"Harv Rev Psychiatry"},{"key":"10.1097\/JGP.0b013e31824361de_bib23","first-page":"24","article-title":"Sleep, health, and aging. Bridging the gap between science and clinical practice","volume":"59","author":"Kryger","year":"2004","journal-title":"Geriatrics"},{"key":"10.1097\/JGP.0b013e31824361de_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.iac.2010.09.005","article-title":"Neuroendocrine effects of stress on immunity in the elderly: implications for inflammatory disease","volume":"31","author":"Heffner","year":"2011","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1097\/JGP.0b013e31824361de_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","article-title":"Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty","volume":"51","author":"Ershler","year":"2000","journal-title":"Annu Rev Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib26","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1186\/gb-2007-8-9-r189","article-title":"Social regulation of gene expression in human leukocytes","volume":"8","author":"Cole","year":"2007","journal-title":"Genome Biol"},{"key":"10.1097\/JGP.0b013e31824361de_bib27","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1001\/archinte.161.9.1194","article-title":"An evidence-based assessment of federal guidelines for overweight and obesity as they apply to elderly persons","volume":"161","author":"Heiat","year":"2001","journal-title":"Arch Intern Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib28","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1076\/jcen.20.3.310.823","article-title":"The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity","volume":"20","author":"Randolph","year":"1998","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1097\/JGP.0b013e31824361de_bib29","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2007.03.011","article-title":"The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis","volume":"21","author":"Steptoe","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1097\/JGP.0b013e31824361de_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"key":"10.1097\/JGP.0b013e31824361de_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/sleep\/29.1.112","article-title":"Validation of a 3-factor scoring model for the Pittsburgh Sleep Quality Index in older adults","volume":"29","author":"Cole","year":"2006","journal-title":"Sleep"},{"key":"10.1097\/JGP.0b013e31824361de_bib32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0022-3999(02)00330-6","article-title":"Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia","volume":"53","author":"Backhaus","year":"2002","journal-title":"J Psychosom Res"},{"key":"10.1097\/JGP.0b013e31824361de_bib33","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","article-title":"Development and validation of brief measures of positive and negative affect: the PANAS scales","volume":"54","author":"Watson","year":"1988","journal-title":"J Pers Soc Psychol"},{"key":"10.1097\/JGP.0b013e31824361de_bib34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/0164027592142001","article-title":"Assessing subjective well-being in the old\u2013old: The PANAS as a measure of orthogonal dimensions of positive and negative affect","volume":"14","author":"Kercher","year":"1992","journal-title":"Res Aging"},{"key":"10.1097\/JGP.0b013e31824361de_bib35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J Health Soc Behav"},{"key":"10.1097\/JGP.0b013e31824361de_bib36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/036107301750074051","article-title":"Perceived stress and coping resource availability as predictors of life satisfaction in young, middle-aged, and older adults","volume":"27","author":"Hamarat","year":"2001","journal-title":"Exp Aging Res"},{"key":"10.1097\/JGP.0b013e31824361de_bib37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1207\/s15327752jpa6601_2","article-title":"UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure","volume":"66","author":"Russell","year":"1996","journal-title":"J Pers Assess"},{"key":"10.1097\/JGP.0b013e31824361de_bib38","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/13607860410001725054","article-title":"Loneliness and depression in independent living retirement communities: risk and resilience factors","volume":"8","author":"Adams","year":"2004","journal-title":"Aging Ment Health"},{"key":"10.1097\/JGP.0b013e31824361de_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a Geriatric Depression Screening Scale: a preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J Psychiatr Res"},{"key":"10.1097\/JGP.0b013e31824361de_bib40","series-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Strauss","year":"2006"},{"key":"10.1097\/JGP.0b013e31824361de_bib41","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator\u2013mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"key":"10.1097\/JGP.0b013e31824361de_bib42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib43","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1073\/pnas.1531903100","article-title":"Chronic stress and age-related increases in the proinflammatory cytokine IL-6","volume":"100","author":"Kiecolt-Glaser","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1097\/JGP.0b013e31824361de_bib44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.biopsycho.2010.01.016","article-title":"Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression","volume":"84","author":"Weinstein","year":"2010","journal-title":"Biol Psychol"},{"key":"10.1097\/JGP.0b013e31824361de_bib45","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0002-9343(99)00066-2","article-title":"Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly","volume":"106","author":"Harris","year":"1999","journal-title":"Am J Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.smrv.2009.06.001","article-title":"Searching for the daytime impairments of primary insomnia","volume":"14","author":"Shekleton","year":"2010","journal-title":"Sleep Med Rev"},{"key":"10.1097\/JGP.0b013e31824361de_bib47","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1001\/archinte.166.16.1756","article-title":"Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation","volume":"166","author":"Irwin","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1097\/JGP.0b013e31824361de_bib48","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/JGP.0b013e3181557b69","article-title":"Sleeping well, aging well: a descriptive and cross-sectional study of sleep in \u201csuccessful agers\u201d 75 and older","volume":"16","author":"Driscoll","year":"2008","journal-title":"Am J Geriatr Psychiatry"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112619915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112619915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T12:52:55Z","timestamp":1561294375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748112619915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S1064748112619915"],"URL":"https:\/\/doi.org\/10.1097\/jgp.0b013e31824361de","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}