{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:44:15Z","timestamp":1793295855653,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Geriatric Psychiatry"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1097\/jgp.0b013e318267016b","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T19:11:52Z","timestamp":1350587512000},"page":"1026-1035","source":"Crossref","is-referenced-by-count":37,"title":["Personality Factors Moderate the Associations Between Apolipoprotein Genotype and Cognitive Function as Well as Late Onset Alzheimer Disease"],"prefix":"10.1016","volume":"20","author":[{"given":"Ilan","family":"Dar-Nimrod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Franks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Porsteinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Duberstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/JGP.0b013e318267016b_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jalz.2012.02.001","article-title":"Alzheimer's disease facts and figures","volume":"8","author":"Alzheimer's Association","year":"2012","journal-title":"Alzheimer's Dement: J Alzheimer's Assoc"},{"issue":"12","key":"10.1097\/JGP.0b013e318267016b_bib2","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.283.12.1571","article-title":"Correlation between elevated levels of amyloid-peptide in the brain and cognitive decline","volume":"283","author":"N\u00e4slund","year":"2000","journal-title":"JAMA"},{"issue":"8","key":"10.1097\/JGP.0b013e318267016b_bib3","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele 4 with late onset familial and sporadic Alzheimer's disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"issue":"4","key":"10.1097\/JGP.0b013e318267016b_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/GIM.0b013e31816b64dc","article-title":"Genetic aspects of Alzheimer disease","volume":"10","author":"Bird","year":"2008","journal-title":"Genet Med"},{"issue":"4","key":"10.1097\/JGP.0b013e318267016b_bib5","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1037\/0882-7974.19.4.592","article-title":"Apolipoprotein E and cognitive performance: a meta-analysis","volume":"19","author":"Small","year":"2004","journal-title":"Psychol Aging"},{"issue":"2","key":"10.1097\/JGP.0b013e318267016b_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/JGP.0b013e31818f3a6b","article-title":"Depressive symptoms moderate the influence of the apolipoproteinE [Latin Small Letter Open E]4 allele on cognitive decline in a sample of community dwelling older adults","volume":"17","author":"Corsentino","year":"2009","journal-title":"Am J Geriatr Psychol"},{"issue":"6","key":"10.1097\/JGP.0b013e318267016b_bib7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/JGP.0b013e3181a2fbb1","article-title":"Personality traits predict emergency department utilization over 3 years in older patients","volume":"17","author":"Chapman","year":"2009","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1097\/JGP.0b013e318267016b_bib8","doi-asserted-by":"crossref","unstructured":"Chapman BP, Roberts BW, Duberstein PR: Personality and longevity: knowns, unknowns, and implications for public health and personalized medicine. J Aging Res 2011;759170. Epub July 10, 2011","DOI":"10.4061\/2011\/759170"},{"issue":"10","key":"10.1097\/JGP.0b013e318267016b_bib9","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1001\/archpsyc.64.10.1204","article-title":"Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment","volume":"64","author":"Wilson","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1097\/JGP.0b013e318267016b_bib10","series-title":"Revised NEO Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI)","author":"Costa","year":"1992"},{"key":"10.1097\/JGP.0b013e318267016b_bib11","series-title":"Handbook of Personality Psychology: Theory and Research","first-page":"159","article-title":"The five-factor theory of personality","author":"McCrae","year":"2008"},{"issue":"3","key":"10.1097\/JGP.0b013e318267016b_bib12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1037\/0022-3514.79.3.452","article-title":"Cross-cultural evidence for the fundamental features of extraversion","volume":"79","author":"Lucas","year":"2000","journal-title":"J Pers Soc Psychol"},{"issue":"4","key":"10.1097\/JGP.0b013e318267016b_bib13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/JGP.0b013e3181c2941b","article-title":"Trait neuroticism, depression, and cognitive function in older primary care patients","volume":"18","author":"Boyle","year":"2010","journal-title":"Am J Geriatr Psychiatry"},{"issue":"7","key":"10.1097\/JGP.0b013e318267016b_bib14","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/JGP.0b013e31822cc9cb","article-title":"Personality predicts cognitive function over seven years in older persons","volume":"20","author":"Chapman","year":"2012","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1097\/JGP.0b013e318267016b_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1037\/a0021377","article-title":"Personality and risk for Alzheimer's disease in adults 72 years of age and older: a 6-year follow-up","volume":"26","author":"Duberstein","year":"2011","journal-title":"Psychol Aging"},{"issue":"3","key":"10.1097\/JGP.0b013e318267016b_bib16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/bimj.200810425","article-title":"Simultaneous inference in general parametric models","volume":"50","author":"Hothorn","year":"2008","journal-title":"Biom J"},{"issue":"3","key":"10.1097\/JGP.0b013e318267016b_bib17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1176\/appi.neuropsych.16.3.320","article-title":"A distinctive interaction between chronic anxiety and problem solving in asymptomatic APOE e4 homozygotes","volume":"16","author":"Caselli","year":"2004","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"1","key":"10.1097\/JGP.0b013e318267016b_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1467-9450.2010.00844.x","article-title":"Cognitive deficits in relation to personality type and hypothalamic-pituitary-adrenal (HPA) axis dysfunction in women with stress-related exhaustion","volume":"52","author":"Sandstr\u00f6m","year":"2011","journal-title":"Scand J Psychol"},{"issue":"1","key":"10.1097\/JGP.0b013e318267016b_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1017\/S0033291700033675","article-title":"Enhanced adrenal sensitivity to adrenocorticotrophic hormone (ACTH) is evidence of HPA axis hyperactivity in Alzheimer's disease","volume":"26","author":"O'Brien","year":"1996","journal-title":"Psychol Med"},{"issue":"19","key":"10.1097\/JGP.0b013e318267016b_bib20","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1001\/jama.2008.683","article-title":"Ginkgo biloba for prevention of dementia","volume":"300","author":"DeKosky","year":"2008","journal-title":"JAMA"},{"issue":"3","key":"10.1097\/JGP.0b013e318267016b_bib21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cct.2006.02.007","article-title":"The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia","volume":"27","author":"DeKosky","year":"2006","journal-title":"Contemp Clin Trials"},{"issue":"2","key":"10.1097\/JGP.0b013e318267016b_bib22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/01.STR.29.2.388","article-title":"Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study","volume":"29","author":"Kuller","year":"1998","journal-title":"Stroke"},{"issue":"15","key":"10.1097\/JGP.0b013e318267016b_bib23","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/archinte.159.15.1701","article-title":"Screening for depression in the older adult: criterion validity of the 10-item Center for Epidemiological Studies Depression Scale (CES-D)","volume":"159","author":"Irwin","year":"1999","journal-title":"Arch Intern Med"},{"issue":"13","key":"10.1097\/JGP.0b013e318267016b_bib24","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archinte.163.13.1524","article-title":"An 18-year follow-up of overweight and risk of Alzheimer disease","volume":"163","author":"Gustafson","year":"2003","journal-title":"Arch Intern Med"},{"issue":"6","key":"10.1097\/JGP.0b013e318267016b_bib25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neurobiolaging.2008.07.015","article-title":"The ACE insertion deletion polymorphism relates to dementia by metabolic phenotype, APOE4, and age of dementia onset","volume":"31","author":"Gustafson","year":"2010","journal-title":"Neurobiol Aging"},{"issue":"11","key":"10.1097\/JGP.0b013e318267016b_bib26","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer's disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am J Psychiatry"},{"key":"10.1097\/JGP.0b013e318267016b_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/ageing\/afj054","article-title":"Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues","volume":"35","author":"Perneczky","year":"2006","journal-title":"Age Ageing"},{"key":"10.1097\/JGP.0b013e318267016b_bib28","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"3\u20134","key":"10.1097\/JGP.0b013e318267016b_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000106721","article-title":"Clinical criteria for vascular dementia: the NINDS-AIREN criteria","volume":"5","author":"Erkinjuntti","year":"1994","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"2","key":"10.1097\/JGP.0b013e318267016b_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/archneur.57.2.191","article-title":"Clinical criteria for the diagnosis of vascular dementia","volume":"57","author":"Chui","year":"2000","journal-title":"Arch Neurol"},{"key":"10.1097\/JGP.0b013e318267016b_bib31","unstructured":"Bates D, Maechler M, Bolker B: Lme4: linear mixed-effects models using S4 classes. R package version 0.999375-39, 2011"},{"issue":"12","key":"10.1097\/JGP.0b013e318267016b_bib32","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1212\/01.WNL.0000036905.59156.A1","article-title":"Cognitive activity and incident AD in a population-based sample of older persons","volume":"59","author":"Wilson","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1097\/JGP.0b013e318267016b_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/jama.2010.1995","article-title":"Association of plasma-amyloid level and cognitive reserve with subsequent cognitive decline","volume":"305","author":"Yaffe","year":"2011","journal-title":"JAMA"},{"issue":"8","key":"10.1097\/JGP.0b013e318267016b_bib34","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1212\/WNL.56.8.1094","article-title":"Increased CSF cortisol in AD is a function of APOE genotype","volume":"56","author":"Peskind","year":"2001","journal-title":"Neurology"},{"issue":"2","key":"10.1097\/JGP.0b013e318267016b_bib35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0149-7634(98)00031-1","article-title":"Stress, glucocorticoids and structural plasticity of the hippocampus","volume":"23","author":"Fuchs","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"10.1097\/JGP.0b013e318267016b_bib36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-2009-1152","article-title":"Effects of stress and stress hormones on amyloid-\u03b2 protein and plaque deposition","volume":"18","author":"Dong","year":"2009","journal-title":"J Alzheimer's Dis"},{"key":"10.1097\/JGP.0b013e318267016b_bib37","series-title":"Memory, Amnesia, and the Hippocampal System","author":"Cohen","year":"1995"},{"issue":"1","key":"10.1097\/JGP.0b013e318267016b_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/0033-2909.132.1.1","article-title":"Patterns of mean-level change in personality traits across the life course: a meta-analysis of longitudinal studies","volume":"132","author":"Roberts","year":"2006","journal-title":"Psychol Bull"},{"issue":"1","key":"10.1097\/JGP.0b013e318267016b_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/14768320500105346","article-title":"Daily worrying and somatic health complaints: Testing the effectiveness of a simple worry reduction intervention","volume":"21","author":"Brosschot","year":"2006","journal-title":"Psychol Health"},{"issue":"1\u20132","key":"10.1097\/JGP.0b013e318267016b_bib40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/00207458908991618","article-title":"The effects of the transcendental mediation technique and progressive muscle relaxation on EEG coherence, stress reactivity, and mental health in black adults","volume":"46","author":"Gaylord","year":"1989","journal-title":"Int J Neurosci"},{"issue":"3","key":"10.1097\/JGP.0b013e318267016b_bib41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0031-9384(98)00071-7","article-title":"ACTH and \u03b2-endorphin in transcendental meditation","volume":"64","author":"Infante","year":"1998","journal-title":"Physiol Behav"},{"issue":"12","key":"10.1097\/JGP.0b013e318267016b_bib42","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1001\/archgenpsychiatry.2009.166","article-title":"Personality change during depression treatment: a placebo-controlled trial","volume":"66","author":"Tang","year":"2009","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1097\/JGP.0b013e318267016b_bib43","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1037\/a0025918","article-title":"Can an old dog learn (and want to experience) new tricks? Cognitive training increases openness to experience in older adults","volume":"27","author":"Jackson","year":"2012","journal-title":"Psych Aging"},{"issue":"5","key":"10.1097\/JGP.0b013e318267016b_bib44","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1037\/a0024678","article-title":"Some thoughts on essence placeholders, interactionism, and heritability: reply to Haslam and Turkheimer","volume":"137","author":"Dar-Nimrod","year":"2011","journal-title":"Psychol Bull"},{"issue":"5","key":"10.1097\/JGP.0b013e318267016b_bib45","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1037\/a0021860","article-title":"Genetic essentialism: on the deceptive determinism of DNA","volume":"137","author":"Dar-Nimrod","year":"2011","journal-title":"Psychol Bull"},{"issue":"5798","key":"10.1097\/JGP.0b013e318267016b_bib46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1126\/science.1131100","article-title":"Exposure to scientific theories affects women's math performance","volume":"314","author":"Dar-Nimrod","year":"2006","journal-title":"Science"},{"issue":"2","key":"10.1097\/JGP.0b013e318267016b_bib47","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1037\/0033-2909.114.2.376","article-title":"Statistical difficulties of detecting interactions and moderator effects","volume":"114","author":"McClelland","year":"1993","journal-title":"Psychol Bull"}],"container-title":["The American Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112620144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1064748112620144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T20:22:45Z","timestamp":1562271765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1064748112620144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1064748112620144"],"URL":"https:\/\/doi.org\/10.1097\/jgp.0b013e318267016b","relation":{},"ISSN":["1064-7481"],"issn-type":[{"value":"1064-7481","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}