{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:10:25Z","timestamp":1792980625625,"version":"4.5.0"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/ http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Postoperative cognitive dysfunction (POCD) is a common neurological system disorder in surgical patients. The choice of anesthetic can potentially reduce POCD. The authors performed this network meta-analysis to compare different anesthetic drugs in reducing the incidence of POCD for elderly people undergoing noncardiac surgery. We searched MEDLINE, EMBASE, the Cochrane Library, and the Web of Science for randomized controlled trials comparing the different anesthetic drugs for noncardiac surgery in elderly from inception until July, 2022. The protocol was registered on the PROSPERO database (CRD#42020183014). A total of 34 trials involving 4314 patients undergoing noncardiac surgery in elderly were included. The incidence of POCD for each anesthetic drug was placebo (27.7%), dexmedetomidine (12.9%), ketamine (15.2%), propofol (16.8%), fentanyl (23.9%), midazolam (11.3%), sufentanil (6.3%), sevoflurane (24.0%), and desflurane (28.3%). Pairwise and network meta-analysis showed dexmedetomidine was significantly reducing the incidence of POCD when compared with placebo. Network meta-analysis also suggested dexmedetomidine was significantly reducing the incidence of POCD when compared with sevoflurane. Sufentanil and dexmedetomidine ranked the first and second in reducing the incidence of POCD with the surface under the cumulative ranking curve value of 87.4 and 81.5%. Sufentanil and dexmedetomidine had the greatest possibility to reduce the incidence of POCD for elderly people undergoing noncardiac surgery.<\/jats:p>","DOI":"10.1097\/js9.0000000000000001","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T11:01:08Z","timestamp":1677063668000},"page":"21-31","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":100,"title":["Preventing postoperative cognitive dysfunction using anesthetic drugs in elderly patients undergoing noncardiac surgery: a systematic review and meta-analysis"],"prefix":"10.1097","volume":"109","author":[{"given":"Kuan","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Wuhan Mental Health Center"},{"name":"Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology"},{"name":"Research Center for Psychological and Health Sciences, China University of Geosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Wuhan Mental Health Center"},{"name":"Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology"},{"name":"Research Center for Psychological and Health Sciences, China University of Geosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Wuhan Mental Health Center"},{"name":"Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology"},{"name":"Research Center for Psychological and Health Sciences, China University of Geosciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1]]},"reference":[{"key":"R1-20250824","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1213\/ANE.0000000000003514","article-title":"Postoperative cognitive dysfunction and noncardiac surgery","volume":"127","author":"Evered","year":"2018","journal-title":"Anesth Analg"},{"key":"R2-20250824","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bja.2017.11.087","article-title":"Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018","volume":"121","author":"Evered","year":"2018","journal-title":"Br J Anaesth"},{"key":"R3-20250824","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(97)07382-0","article-title":"Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. 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