{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:25:19Z","timestamp":1793658319581,"version":"4.5.1"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Osteomyelitis (OM) is a serious infection of the bone, often resulting from diabetic foot ulcers, trauma, or surgical interventions. Given its complex pathophysiology and recurrent nature, identifying reliable risk factors is essential for early diagnosis and intervention. This study identifies independent OM risk factors through a systematic review and meta-analysis method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A search was conducted across several databases up to January 2025. Data were extracted independently, and study quality was assessed using the Newcastle\u2013Ottawa Scale. Statistical analysis was performed with RevMan 5.3 and Stata 15.0 software, using univariate and multivariate analyses. Heterogeneity was assessed by methods of subgroup analysis and sensitive analysis, and publication bias was evaluated with Egger\u2019s test and funnel plots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 4019 potential articles were systematically reviewed, with 27 studies (n\u00a0=\u00a011\u00a0941 participants) were included. These studies were analyzed to identify risk factors across five categories: demographic features, medical history, clinical features, laboratory findings, and bacterial characteristics. Medical history factors, such as history of foot ulcers\/foot disease (OR\u00a0=\u00a02.520), operation duration time (&gt;3\u00a0hours, OR\u00a0=\u00a01.740), and incision length &gt;10 cm (OR\u00a0=\u00a06.530), were significant. Clinical features including inflamed ulcer (OR\u00a0=\u00a06.200), fever (OR\u00a0=\u00a02.200), and ulcer size &gt;4\/5 cm\n                      <jats:sup>2<\/jats:sup>\n                      (OR\u00a0=\u00a02.740) also increased OM risk. Laboratory findings such as elevated HbA1c (OR\u00a0=\u00a01.140), hypoalbuminemia (OR\u00a0=\u00a01.740), anemia (OR\u00a0=\u00a01.540), and microbiological perspective such as polymicrobial infections (OR\u00a0=\u00a02.580) were also recognized as independent risk factors of OM. Subgroup analysis accounted for heterogeneity arising from the type of OM and different risk factor characteristics. Sensitivity analysis confirmed the reliability of the results. Additionally, both funnel plots and Egger tests showed no evidence of publication bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first meta-analysis to integrate univariate and multivariate evidence on OM risk factors. It establishes clinically preventable risk factors across OM subtypes, enabling early targeted interventions to reduce amputations and healthcare burdens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/js9.0000000000002811","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T11:01:58Z","timestamp":1751540518000},"page":"5606-5622","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors for osteomyelitis: a systematic review and meta-analysis"],"prefix":"10.1097","volume":"111","author":[{"given":"Ze","family":"Yang","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaofeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"R1-20261030","doi-asserted-by":"crossref","first-page":"369\u201379","DOI":"10.1016\/S0140-6736(04)16727-5","article-title":"Osteomyelitis","volume":"364","author":"Lew","year":"2004","journal-title":"Lancet"},{"key":"R2-20261030","doi-asserted-by":"crossref","first-page":"2721\u201331","DOI":"10.1097\/JS9.0000000000000502","article-title":"Epidemiological updates of post-traumatic related limb osteomyelitis in china: a 10 years multicentre cohort study","volume":"109","author":"Ren","year":"2023","journal-title":"Int J Surg"},{"key":"R3-20261030","doi-asserted-by":"crossref","first-page":"1\u20139","DOI":"10.1007\/BF00934149","article-title":"Post-traumatic osteomyelitis. pathophysiology and management","volume":"108","author":"Roesgen","year":"1989","journal-title":"Arch Orthop Trauma Surg"},{"key":"R4-20261030","first-page":"395\u2013402","article-title":"Osteomyelitis: diagnosis and treatment","volume":"104","author":"Bury","year":"2021","journal-title":"Am Family Phys"},{"key":"R5-20261030","doi-asserted-by":"crossref","first-page":"2\u20137","DOI":"10.7547\/1030002","article-title":"2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections","volume":"103","author":"Lipsky","year":"2013","journal-title":"J Am Podiatr Med Assoc"},{"key":"R6-20261030","first-page":"1173","article-title":"Duration of antibiotic treatment for foot osteomyelitis in people with diabetes","volume":"13","author":"Gramberg","year":"2024","journal-title":"Antibiotics (Basel, Switzerland)"},{"key":"R7-20261030","doi-asserted-by":"crossref","first-page":"e2023065397","DOI":"10.1542\/peds.2023-065397","article-title":"Outcomes of early surgical procedures for children with acute hematogenous osteomyelitis","volume":"154","author":"Searns","year":"2024","journal-title":"Pediatrics"},{"key":"R8-20261030","doi-asserted-by":"crossref","first-page":"837\u201345","DOI":"10.2106\/JBJS.N.01350","article-title":"Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009","volume":"97","author":"Kremers","year":"2015","journal-title":"J Bone Joint Surg Am Vol"},{"key":"R9-20261030","first-page":"256\u201362","article-title":"Key features of bone and joint infections following the implementation of reference centers in France","volume":"48","author":"Laurent","year":"2018","journal-title":"Med Mal Infectieuses"},{"key":"R10-20261030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/1471-2334-14-443","article-title":"Determinants of methicillin-susceptible Staphylococcus aureus native bone and joint infection treatment failure: a retrospective cohort study","volume":"14","author":"Valour","year":"2014","journal-title":"BMC Infect Dis"},{"key":"R11-20261030","doi-asserted-by":"crossref","first-page":"535\u201340","DOI":"10.1016\/j.jpsychores.2014.09.008","article-title":"Increased depression risk among patients with chronic osteomyelitis","volume":"77","author":"Tseng","year":"2014","journal-title":"J Psychosom Res"},{"key":"R12-20261030","doi-asserted-by":"crossref","first-page":"1450\u201354","DOI":"10.1136\/heartjnl-2014-305652","article-title":"Increased risk of coronary heart disease in patients with chronic osteomyelitis: a population-based study in a cohort of 23 million","volume":"100","author":"Hsiao","year":"2014","journal-title":"Heart"},{"key":"R13-20261030","first-page":"633\u201339","article-title":"Increased risk of ischaemic stroke amongst patients with chronic osteomyelitis: a population-based cohort study in Taiwan","volume":"22","author":"Tseng","year":"2015","journal-title":"Eur J Neurol"},{"key":"R14-20261030","doi-asserted-by":"crossref","first-page":"573\u201379","DOI":"10.1160\/TH14-01-0012","article-title":"Association between chronic osteomyelitis and deep-vein thrombosis. analysis of a nationwide population-based registry","volume":"112","author":"Lin","year":"2014","journal-title":"Thromb Haemost"},{"key":"R15-20261030","first-page":"100082","article-title":"Transparency in the reporting of artificial intelligence \u2013 the TITAN guideline","volume":"10","author":"Agha","year":"2025","journal-title":"Premier J Sci"},{"key":"R16-20261030","doi-asserted-by":"crossref","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int J Surg"},{"key":"R17-20261030","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ (Clinical Research Ed)"},{"key":"R18-20261030","doi-asserted-by":"crossref","first-page":"2373\u201383","DOI":"10.1001\/jama.2015.15845","article-title":"Prevalence of depression and depressive symptoms among resident physicians: a systematic review and meta-analysis","volume":"314","author":"Mata","year":"2015","journal-title":"Jama"},{"key":"R19-20261030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ajmg.a.20137","article-title":"IL-1 alpha (\u2212889) promoter polymorphism is a risk factor for osteomyelitis","volume":"119a","author":"Asensi","year":"2003","journal-title":"Am J Med Genet A"},{"key":"R20-20261030","doi-asserted-by":"crossref","first-page":"102\u201309","DOI":"10.1016\/j.jhin.2023.07.008","article-title":"Vertebral osteomyelitis after spine instrumentation surgery: risk factors and management","volume":"140","author":"Benavent","year":"2023","journal-title":"J Hosp Infect"},{"key":"R21-20261030","doi-asserted-by":"crossref","first-page":"962\u201368","DOI":"10.21037\/jtd-21-1694","article-title":"Incidence and risk factors for sternal osteomyelitis after median sternotomy","volume":"14","author":"Cha","year":"2022","journal-title":"J Thorac Dis"},{"key":"R22-20261030","first-page":"510\u201316","article-title":"Correlation of platelet\/lymphocyte ratio and neutrophil\/lymphocyte ratio with osteomyelitis and amputation in diabetic foot infection patients","volume":"28","author":"Ding","year":"2020","journal-title":"Chin J Diabetes"},{"key":"R24-20261030","first-page":"122\u201326","article-title":"Analysis of clinical features and pathogenic bacteria in 333 patients with osteomyelitis","volume":"27","author":"Feng","year":"2021","journal-title":"J Pract Orthop"},{"key":"R26-20261030","first-page":"709\u201313","article-title":"Changes and significance of erythrocyte sedimentation rate, leukocyte, procalcitonin and interleukin-6 levels in patients with acute osteomyelitis","volume":"52","author":"He","year":"2023","journal-title":"Shaanxi Med J"},{"key":"R27-20261030","first-page":"1782\u201386","article-title":"Pathogenic bacteria distribution and risk factors analysis of diabetic foot combined with osteomyelitis wound","volume":"35","author":"Huang","year":"2015","journal-title":"J Southern Med Univ"},{"key":"R28-20261030","first-page":"329\u201333","article-title":"Dynamic changes of serum IFN-\u03b3, IL-6 and TNF-\u03b1 in patients with acute osteomyelitis and their clinical significance","volume":"27","author":"Huang","year":"2020","journal-title":"Marker Immunoassay Clin"},{"key":"R29-20261030","first-page":"1189\u201394","article-title":"The clinical value of serum magnesium level combined with platelet to lymphocyte ratio in the diagnosis of osteomyelitis after limb trauma","volume":"40","author":"Huang","year":"2023","journal-title":"J Guangxi Med Univ"},{"key":"R30-20261030","first-page":"102000","article-title":"Is the duration of diabetic foot ulcers an independent risk factor for developing diabetic foot osteomyelitis?","volume":"56","author":"Jaroenarpornwatana","year":"2023","journal-title":"Foot (Edinburgh, Scotland)"},{"key":"R32-20261030","first-page":"837\u201342","article-title":"Correlation between tumor necrosis factor-\u03b1 and lymphotoxin-\u03b1 gene polymorphisms and the risk of traumatic osteomyelitis of limbs in Chinese","volume":"20","author":"Jiang","year":"2018","journal-title":"Chin J Orthop Trauma"},{"key":"R33-20261030","doi-asserted-by":"crossref","first-page":"1226\u201333","DOI":"10.1093\/cid\/ciad377","article-title":"Risk factors and outcomes of hematogenous vertebral osteomyelitis in patients with Staphylococcus aureus bacteremia","volume":"77","author":"Kinamon","year":"2023","journal-title":"Clin Infect Dis"},{"key":"R34-20261030","first-page":"26","article-title":"Analysis of risk factors for diabetic foot complicated with osteomyelitis in type 2 diabetic patients","author":"Lai","year":"2019","journal-title":"Clin Med Eng"},{"key":"R35-20261030","doi-asserted-by":"crossref","first-page":"347\u201352","DOI":"10.1016\/j.diabres.2008.11.030","article-title":"Risk factors for developing osteomyelitis in patients with diabetic foot wounds","volume":"83","author":"Lavery","year":"2009","journal-title":"Diabetes Res Clin Pract"},{"key":"R36-20261030","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1365-2249.2005.03002.x","article-title":"The toll-like receptor 4 (Asp299Gly) polymorphism is a risk factor for Gram-negative and haematogenous osteomyelitis","volume":"143","author":"Montes","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"R37-20261030","first-page":"1348\u201350","article-title":"Distribution characteristics of pathogenic bacteria on infected wound of diabetic foot and analysis of influencing factors leading to osteomyelitis","volume":"25","author":"Ni","year":"2021","journal-title":"Chin Exp Diagn"},{"key":"R38-20261030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12920-024-01799-6","article-title":"Chronic osteomyelitis risk is associated with NLRP3 gene rs10754558 polymorphism in a Chinese Han Population","volume":"17","author":"Qu","year":"2024","journal-title":"BMC Med. Genomics"},{"key":"R39-20261030","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.3390\/jcm11206072","article-title":"Risk factors for postoperative osteomyelitis among patients after bone fracture: a matched case-control study","volume":"11","author":"Slyamova","year":"2022","journal-title":"J Clin Med"},{"key":"R40-20261030","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/23744235.2017.1347816","article-title":"Cyclooxygenase-2 (COX-2) polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population","volume":"49","author":"Wang","year":"2017","journal-title":"Infect Dis"},{"key":"R41-20261030","first-page":"153\u201355","article-title":"MRI diagnosis of type 2 diabetic foot complicated with osteomyelitis and analysis of its influencing factors","volume":"22","author":"Wu","year":"2024","journal-title":"Chin J CT MRI"},{"key":"R42-20261030","first-page":"27","article-title":"Analysis of risk factors for postoperative osteomyelitis of lower limb bone fracture","volume":"29","author":"Xu","year":"2017","journal-title":"PLA Med J"},{"key":"R43-20261030","doi-asserted-by":"crossref","first-page":"7483537","DOI":"10.1155\/2019\/7483537","article-title":"Interleukin-1 beta gene polymorphism rs16944 may associate with increased susceptibility to extremity chronic osteomyelitis in Chinese Han Population","volume":"2019","author":"Yao","year":"2019","journal-title":"Biomed Res Int"},{"key":"R44-20261030","first-page":"39\u201340","article-title":"Analysis of risk factors of diabetic foot complicated with osteomyelitis in type 2 diabetic patients","volume":"28","author":"Zhang","year":"2019","journal-title":"Biped Health Care"},{"key":"R46-20261030","doi-asserted-by":"crossref","first-page":"385\u2013400","DOI":"10.1038\/s41579-022-00686-0","article-title":"Skeletal infections: microbial pathogenesis, immunity and clinical management","volume":"20","author":"Masters","year":"2022","journal-title":"Nat Rev Microbiol"},{"key":"R47-20261030","doi-asserted-by":"crossref","first-page":"ofae236","DOI":"10.1093\/ofid\/ofae236","article-title":"Diabetic foot osteomyelitis undergoing amputation: epidemiology and prognostic factors for treatment failure","volume":"11","author":"Baek","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"R48-20261030","doi-asserted-by":"crossref","first-page":"1442\u201347","DOI":"10.2337\/diacare.24.8.1442","article-title":"Effectiveness of the diabetic foot risk classification system of the international working group on the diabetic foot","volume":"24","author":"Peters","year":"2001","journal-title":"diabetes care"},{"key":"R49-20261030","doi-asserted-by":"crossref","first-page":"916\u201321","DOI":"10.1053\/j.jfas.2023.07.004","article-title":"Impact of podiatric surgery consultation for foot and ankle wounds on patient outcomes in a community hospital","volume":"62","author":"Behme","year":"2023","journal-title":"J Foot Ankle Surg"},{"key":"R50-20261030","doi-asserted-by":"crossref","first-page":"212s","DOI":"10.1097\/01.prs.0000222737.09322.77","article-title":"Diagnosis and treatment of diabetic foot infections","volume":"117","author":"Lipsky","year":"2006","journal-title":"Plast Reconstr Surg"},{"key":"R51-20261030","doi-asserted-by":"crossref","first-page":"381\u201384","DOI":"10.1089\/sur.2015.173","article-title":"Incidence and risk factors for infection when teicoplanin is included for prophylaxis in patients with hip fracture","volume":"17","author":"Capdevila","year":"2016","journal-title":"Surg Infect"},{"key":"R52-20261030","doi-asserted-by":"crossref","first-page":"773\u201380","DOI":"10.1111\/iwj.13096","article-title":"Surgical site infection following elective orthopaedic surgeries in geriatric patients: incidence and associated risk factors","volume":"16","author":"Liang","year":"2019","journal-title":"Int Wound J"},{"key":"R53-20261030","first-page":"273\u201386","article-title":"Hematogenous osteomyelitis in adults","volume":"33","author":"Strecker","year":"2004","journal-title":"Orthopade"},{"key":"R54-20261030","doi-asserted-by":"crossref","first-page":"555\u201361","DOI":"10.1111\/j.1742-481X.2012.01022.x","article-title":"Risk factors for recurrence of diabetic foot ulcers: prospective follow-up analysis in the Eurodiale subgroup","volume":"10","author":"Dubsk\u00fd","year":"2013","journal-title":"Int Wound J"},{"key":"R55-20261030","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1186\/s13018-024-05166-0","article-title":"Postoperative decrease in serum albumin as predictor of early acute periprosthetic infection after total knee arthroplasty","volume":"19","author":"Ishii","year":"2024","journal-title":"J Orthopaedic Surg Res"},{"key":"R56-20261030","doi-asserted-by":"crossref","first-page":"1955\u201361","DOI":"10.1093\/cid\/ciz109","article-title":"Clinical and microbiologic variables predictive of orthopedic complications following Staphylococcus aureus acute hematogenous osteoarticular infections in children","volume":"69","author":"McNeil","year":"2019","journal-title":"Clin Infect Dis"},{"key":"R57-20261030","doi-asserted-by":"crossref","first-page":"335\u201349","DOI":"10.1038\/nri3843","article-title":"Fever and the thermal regulation of immunity: the immune system feels the heat","volume":"15","author":"Evans","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"R58-20261030","doi-asserted-by":"crossref","first-page":"259\u201365","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R59-20261030","doi-asserted-by":"crossref","first-page":"1288\u201393","DOI":"10.2337\/dc05-2425","article-title":"Risk factors for foot infections in individuals with diabetes","volume":"29","author":"Lavery","year":"2006","journal-title":"Diabetes Care"},{"key":"R60-20261030","doi-asserted-by":"crossref","first-page":"149\u201353","DOI":"10.7150\/jbji.20002","article-title":"Epidemiological, clinical and microbiological characteristics of patients with post-traumatic osteomyelitis of limb fractures in Southwest China: a hospital-based study","volume":"2","author":"Peng","year":"2017","journal-title":"J Bone Jt Infect"},{"key":"R61-20261030","doi-asserted-by":"crossref","first-page":"1063\u201370","DOI":"10.1017\/S1751731116002433","article-title":"The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers","volume":"11","author":"Paludo","year":"2017","journal-title":"Animal"},{"key":"R62-20261030","doi-asserted-by":"crossref","first-page":"1738\u201347","DOI":"10.1111\/febs.14082","article-title":"CHI3L1 regulation of inflammation and the effects on osteogenesis in a Staphylococcus aureus-induced murine model of osteomyelitis","volume":"284","author":"Chen","year":"2017","journal-title":"FEBS J"},{"key":"R63-20261030","doi-asserted-by":"crossref","first-page":"275\u201386","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J Exp Med"},{"key":"R64-20261030","doi-asserted-by":"crossref","first-page":"6398\u2013401","DOI":"10.1128\/IAI.68.11.6398-6401.2000","article-title":"A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection","volume":"68","author":"Lorenz","year":"2000","journal-title":"Infect Immun"},{"key":"R65-20261030","doi-asserted-by":"crossref","first-page":"1631\u201336","DOI":"10.1161\/01.ATV.0000030340.80207.C5","article-title":"Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response","volume":"22","author":"Papafili","year":"2002","journal-title":"Arteriosclerosis Thrombosis Vasc Biol"},{"key":"R66-20261030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fphar.2014.00152","article-title":"Iron at the interface of immunity and infection","volume":"5","author":"Nairz","year":"2014","journal-title":"Front Pharmacol"}],"container-title":["International Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/JS9.0000000000002811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:05:03Z","timestamp":1793351103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1097\/JS9.0000000000002811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/js9.0000000000002811","relation":{},"ISSN":["1743-9159","1743-9191"],"issn-type":[{"value":"1743-9159","type":"electronic"},{"value":"1743-9191","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"2025-03-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}