{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:58:41Z","timestamp":1773082721246,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1918,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thoracic Oncology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1097\/jto.0b013e3181e392a8","type":"journal-article","created":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T11:56:08Z","timestamp":1282823768000},"page":"1439-1446","source":"Crossref","is-referenced-by-count":53,"title":["Insulin-Like Growth Factor-1 Receptor Expression in Thymic Malignancies"],"prefix":"10.1016","volume":"5","author":[{"given":"Nicolas","family":"Girard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Teruya-Feldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eden C.","family":"Payabyab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Riely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie W.","family":"Rusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Kris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen F.","family":"Zakowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1097\/JTO.0b013e3181e392a8_bib1","series-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart","first-page":"146","article-title":"WHO histological classification of tumours of the thymus","year":"2004"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib2","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R","article-title":"Follow-up study of thymomas with special reference to their clinical stages","volume":"48","author":"Masaoka","year":"1981","journal-title":"Cancer"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/JTO.0b013e31818e105c","article-title":"Thymoma: a focus on current therapeutic management","volume":"4","author":"Girard","year":"2008","journal-title":"J Thorac Oncol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib4","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1158\/1078-0432.CCR-07-4879","article-title":"The type 1 insulin-like growth factor receptor pathway","volume":"14","author":"Chitnis","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/annonc\/mdp357","article-title":"Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients","volume":"21","author":"Cappuzzo","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib6","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.humpath.2004.09.005","article-title":"Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis","volume":"35","author":"Shimizu","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1535-6108(02)00055-7","article-title":"Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis","volume":"1","author":"Lopez","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib8","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/sj.onc.1209955","article-title":"Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation","volume":"26","author":"Jones","year":"2007","journal-title":"Oncogene"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib9","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1038\/onc.2009.172","article-title":"Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions","volume":"28","author":"Gualberto","year":"2009","journal-title":"Oncogene"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib10","doi-asserted-by":"crossref","first-page":"e7273","DOI":"10.1371\/journal.pone.0007273","article-title":"High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)","volume":"4","author":"Gong","year":"2009","journal-title":"PLoS One"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<1::AID-JCP1>3.0.CO;2-J","article-title":"Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis","volume":"183","author":"Grimberg","year":"2000","journal-title":"J Cell Physiol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib12","doi-asserted-by":"crossref","first-page":"6790","DOI":"10.1158\/1078-0432.CCR-09-0644","article-title":"Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas","volume":"15","author":"Girard","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib13","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nm0798-844","article-title":"Tissue microarrays for high-throughput molecular profiling of tumor specimens","volume":"4","author":"Kononen","year":"1998","journal-title":"Nat Med"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib14","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1200\/JCO.2009.24.6611","article-title":"Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: a comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression","volume":"28","author":"Dziadziuszko","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non-parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib16","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1200\/jco.2007.25.18_suppl.3586","article-title":"Phase I dose escalation study of the anti-IGF-1R monoclonal antibody CP-751,871 in patients with refractory solid tumors","volume":"25","author":"Haluska","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib17","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/annonc\/mdn727","article-title":"High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients","volume":"20","author":"Ludovini","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib18","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/carcin\/bgl247","article-title":"Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma","volume":"28","author":"Imsumran","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.hoc.2008.03.002","article-title":"Thymic carcinoma: current concepts and histologic features","volume":"22","author":"Moran","year":"2008","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib20","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1158\/1078-0432.CCR-06-2077","article-title":"Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib","volume":"13","author":"Morgillo","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib21","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1677\/erc.1.00799","article-title":"Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells","volume":"11","author":"Jones","year":"2004","journal-title":"Endocr Relat Cancer"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib22","doi-asserted-by":"crossref","first-page":"10100","DOI":"10.1158\/0008-5472.CAN-06-1684","article-title":"Heterodimerization of insulin-like growth factor receptor\/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib","volume":"66","author":"Morgillo","year":"2006","journal-title":"Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10549-007-9763-9","article-title":"Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib (\u2018Iressa\u2019) response and resistance","volume":"111","author":"Knowlden","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib24","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2007.02.012","article-title":"The EGF receptor interacts with the type 1 IGF receptor and regulates its stability","volume":"355","author":"Riedemann","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib25","doi-asserted-by":"crossref","first-page":"8039","DOI":"10.1158\/0008-5472.CAN-08-1712","article-title":"Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody","volume":"68","author":"Cao","year":"2008","journal-title":"Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib26","first-page":"200","article-title":"Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling","volume":"62","author":"Chakravarti","year":"2002","journal-title":"Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib27","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.bjc.6604661","article-title":"Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer","volume":"99","author":"Huang","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib28","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.athoracsur.2003.07.042","article-title":"WHO histologic classification is a prognostic indicator in thymoma","volume":"77","author":"Kondo","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10549-006-9471-x","article-title":"Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer","volume":"106","author":"Mulligan","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib31","first-page":"3736","article-title":"Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer","volume":"53","author":"Papa","year":"1993","journal-title":"Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib32","doi-asserted-by":"crossref","first-page":"10238","DOI":"10.1158\/0008-5472.CAN-08-2755","article-title":"Phosphorylated insulin-like growth factor-i\/insulin receptor is present in all breast cancer subtypes and is related to poor survival","volume":"68","author":"Law","year":"2008","journal-title":"Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib33","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/sj.leu.2403997","article-title":"IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma","volume":"20","author":"Chng","year":"2006","journal-title":"Leukemia"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1158\/1078-0432.206.11.1","article-title":"Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma","volume":"11","author":"Ahl\u00e9n","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib35","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/hupa.2002.126186","article-title":"High expression levels of insulin-like growth factor-I receptor predict poor survival among women with clear-cell renal cell carcinomas","volume":"33","author":"Parker","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib36","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.bjc.6604661","article-title":"Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer","volume":"99","author":"Huang","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib37","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1200\/jco.2007.25.18_suppl.7506","article-title":"Efficacy of the anti-insulin like growth factor I receptor (IGF-IR) antibody CP-751871 in combination with paclitaxel and carboplatin as first-line treatment for advanced non-small cell lung cancer (NSCLC)","volume":"25","author":"Karp","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3181e392a8_bib29","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1097\/00000478-200212000-00008","article-title":"Correlation of the WHO schema for the classification of thymic epithelial neoplasms with prognosis: a retrospective study of 90 tumors","volume":"26","author":"Chalabreysse","year":"2002","journal-title":"Am J Surg Pathol"}],"container-title":["Journal of Thoracic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086415306225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086415306225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:35:55Z","timestamp":1685752555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556086415306225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1556086415306225"],"URL":"https:\/\/doi.org\/10.1097\/jto.0b013e3181e392a8","relation":{},"ISSN":["1556-0864"],"issn-type":[{"value":"1556-0864","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}