{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:06:01Z","timestamp":1789664761185,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1431,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thoracic Oncology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1097\/jto.0b013e3182307f7e","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T21:06:56Z","timestamp":1317762416000},"page":"57-63","source":"Crossref","is-referenced-by-count":9,"title":["Increasing Age and Carcinoma Not Otherwise Specified: A 20-Year Population Study of 40,118 Lung Cancer Patients"],"prefix":"10.1016","volume":"7","author":[{"given":"Camilla Maria T.","family":"Sagerup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milada","family":"Sm\u00e5stuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom B.","family":"Johannesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5slaug","family":"Helland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odd Terje","family":"Brustugun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/JTO.0b013e3182307f7e_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/thx.2010.151621","article-title":"Sex-specific trends in lung cancer incidence and survival: a population study of 40 118 cases","volume":"66","author":"Sagerup","year":"2011","journal-title":"Thorax"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib2","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1200\/JCO.2007.12.5435","article-title":"Lung cancer in elderly patients: an analysis of the surveillance, epidemiology, and end results database","volume":"25","author":"Owonikoko","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejcts.2004.11.006","article-title":"Results of pulmonary resection for lung cancer in Norway, patients older than 70 years","volume":"27","author":"Rostad","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib4","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJM199912303412706","article-title":"Underrepresentation of patients 65 years of age or older in cancer-treatment trials","volume":"341","author":"Hutchins","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib5","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1001\/jama.291.22.2720","article-title":"Participation in cancer clinical trials: race-, sex-, and age-based disparities","volume":"291","author":"Murthy","year":"2004","journal-title":"JAMA"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib6","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1056\/NEJMoa061884","article-title":"Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer","volume":"355","author":"Sandler","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib7","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1200\/JCO.2007.15.0375","article-title":"Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer","volume":"26","author":"Scagliotti","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib8","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.ejca.2008.10.037","article-title":"Data quality at the Cancer Registry of Norway: an overview of comparability, completeness, validity and timeliness","volume":"45","author":"Larsen","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib10","series-title":"New York NACS. Manual of Tumor Nomenclature and Coding","author":"American Cancer Society","year":"1968"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib11","series-title":"International Classification of Diseases for Oncology","author":"Percy","year":"1990"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib12","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/annonc\/mdf187","article-title":"Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases","volume":"13","author":"Radzikowska","year":"2002","journal-title":"Ann Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1097\/JTO.0b013e3181b28fb9","article-title":"Carcinoma NOS is a common histologic diagnosis and is increasing in proportion among non-small cell lung cancer histologies","volume":"4","author":"Ou","year":"2009","journal-title":"J Thorac Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib14","article-title":"Significance of pretreatment comorbidities in elderly patients with advanced non-small-cell lung cancer treated with chemotherapy or epidermal growth factor receptor-tyrosine kinase inhibitor","author":"Irisa","year":"2010","journal-title":"Med Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib15","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ejcts.2010.09.022","article-title":"Surgical treatment of lung cancer in the octogenarians: results of a nationwide audit","volume":"39","author":"Rivera","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib16","series-title":"Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart","author":"International Agency for Research on Cancer, WHO","year":"2004"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/JTO.0b013e3181d40fac","article-title":"Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimens","volume":"5","author":"Loo","year":"2010","journal-title":"J Thorac Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1378\/chest.109.5.1199","article-title":"Cell type accuracy of bronchial biopsy specimens in primary lung cancer","volume":"109","author":"Cataluna","year":"1996","journal-title":"Chest"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1136\/thx.48.11.1135","article-title":"How reliable is the diagnosis of lung cancer using small biopsy specimens? Report of a UKCCCR Lung Cancer Working Party","volume":"48","author":"Thomas","year":"1993","journal-title":"Thorax"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/thx.39.3.175","article-title":"Diagnosis of lung cancer by fibreoptic bronchoscopy: problems in the histological classification of non-small cell carcinomas","volume":"39","author":"Chuang","year":"1984","journal-title":"Thorax"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib21","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/jcp.34.7.773","article-title":"Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma","volume":"34","author":"Payne","year":"1981","journal-title":"J Clin Pathol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1309\/FK9XMJ19T036LJ70","article-title":"Transthoracic fine-needle aspiration vs concurrent core needle biopsy in diagnosis of intrathoracic lesions: a retrospective comparison of diagnostic accuracy","volume":"125","author":"Gong","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib23","doi-asserted-by":"crossref","unstructured":"Sackett MK, Salomao DR, Donovan JL, et al. Diagnostic concordance of histologic lung cancer type between bronchial biopsy and cytology specimens taken during the same bronchoscopic procedure. Arch Pathol Lab Med 134:1504\u20131512.","DOI":"10.5858\/2009-0363-OA.1"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/thx.41.6.475","article-title":"Bronchial brushing and bronchial biopsy: comparison of diagnostic accuracy and cell typing reliability in lung cancer","volume":"41","author":"Matsuda","year":"1986","journal-title":"Thorax"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/jcp.35.4.414","article-title":"Accuracy of morphological diagnosis of lung cancer in a department of respiratory medicine","volume":"35","author":"Clee","year":"1982","journal-title":"J Clin Pathol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib26","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1200\/JCO.2004.11.022","article-title":"Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer","volume":"22","author":"Johnson","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib27","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/S0140-6736(09)61497-5","article-title":"Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study","volume":"374","author":"Ciuleanu","year":"2009","journal-title":"Lancet"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib28","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/JTO.0b013e3181c6ed9b","article-title":"Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytologic material, using a panel of mucin staining, TTF-1, cytokeratin 5\/6, and P63, and EGFR mutation analysis","volume":"5","author":"Nicholson","year":"2010","journal-title":"J Thorac Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib29","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1200\/JCO.2008.19.4134","article-title":"Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma","volume":"27","author":"Lebanony","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3182307f7e_bib30","doi-asserted-by":"crossref","unstructured":"Sandler A, Yi J, Dahlberg S, et al. Treatment outcomes by tumor histology in Eastern Cooperative Group Study E4599 of bevacizumab with paclitaxel\/carboplatin for advanced non-small cell lung cancer. J Thorac Oncol 5:1416\u20131423.","DOI":"10.1097\/JTO.0b013e3181da36f4"}],"container-title":["Journal of Thoracic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086415317597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086415317597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T23:50:50Z","timestamp":1639007450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556086415317597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1556086415317597"],"URL":"https:\/\/doi.org\/10.1097\/jto.0b013e3182307f7e","relation":{},"ISSN":["1556-0864"],"issn-type":[{"value":"1556-0864","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}