{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:07:18Z","timestamp":1790460438393,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":1249,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thoracic Oncology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1097\/jto.0b013e3182519a42","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T04:16:05Z","timestamp":1337660165000},"page":"1141-1147","source":"Crossref","is-referenced-by-count":122,"title":["Lymphovascular Invasion in Non\u2013Small-Cell Lung Cancer: Implications for Staging and Adjuvant Therapy"],"prefix":"10.1016","volume":"7","author":[{"given":"Kristin A","family":"Higgins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo P","family":"Chino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Ready","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessamy","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris R","family":"Kelsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/JTO.0b013e3182519a42_bib1","series-title":"Cancer Staging Manual- Lung","first-page":"253","author":"AJCC","year":"2010"},{"key":"10.1097\/JTO.0b013e3182519a42_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(06)70804-X","article-title":"Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial","volume":"7","author":"Douillard","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa031644","article-title":"Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer","volume":"350","author":"Arriagada","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1097\/JTO.0b013e3182519a42_bib4","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1056\/NEJMoa043623","article-title":"National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators. Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer","volume":"352","author":"Winton","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1097\/JTO.0b013e3182519a42_bib5","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1200\/JCO.2007.13.9030","article-title":"Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group","volume":"26","author":"Pignon","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib6","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1200\/JCO.2008.16.4855","article-title":"Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups","volume":"26","author":"Strauss","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/gyno.1999.5387","article-title":"A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study","volume":"73","author":"Sedlis","year":"1999","journal-title":"Gynecol Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ygyno.2003.11.048","article-title":"A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study","volume":"92","author":"Keys","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0090-8258(90)90064-R","article-title":"Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva","volume":"38","author":"Heaps","year":"1990","journal-title":"Gynecol Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.oraloncology.2009.10.011","article-title":"Predictors of locoregional recurrence in early stage oral cavity cancer with free surgical margins","volume":"46","author":"Huang","year":"2010","journal-title":"Oral Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jtcvs.2008.12.035","article-title":"Surgical-pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non-small cell lung cancer: a heterogeneous disease","volume":"138","author":"Hsu","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1097\/JTO.0b013e3182519a42_bib12","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0360-3016(00)00750-1","article-title":"Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning","volume":"48","author":"Giraud","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1097\/JTO.0b013e3182519a42_bib13","first-page":"297","article-title":"Combined modality treatment of localized small-cell lung carcinoma. A randomized prospective study of the Southeastern Cancer Study Group","volume":"3","author":"Krauss","year":"1980","journal-title":"Cancer Clin Trials"},{"key":"10.1097\/JTO.0b013e3182519a42_bib14","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/BF02619312","article-title":"Biological and biochemical properties of a human uveal melanocyte-derived cell line","volume":"16","author":"Meyskens","year":"1980","journal-title":"In Vitro"},{"key":"10.1097\/JTO.0b013e3182519a42_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/JTO.0b013e3181f9abca","article-title":"Positron emission tomography\/computed tomography and lymphovascular invasion predict recurrence in stage I lung cancers","volume":"6","author":"Shiono","year":"2011","journal-title":"J Thorac Oncol"},{"key":"10.1097\/JTO.0b013e3182519a42_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cllc.2011.06.011","article-title":"The prognostic significance of lymphovascular invasion on biopsy specimens in lung cancer treated with definitive chemoradiotherapy","volume":"13","author":"Massabeau","year":"2012","journal-title":"Clin Lung Cancer"},{"key":"10.1097\/JTO.0b013e3182519a42_bib17","series-title":"NCCN Clinical Practice Guidelines in Oncology, Non-Small Cell Lung Cancer, (ed Version 2.2012)","author":"Ettinger","year":"2012"},{"key":"10.1097\/JTO.0b013e3182519a42_bib18","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1002\/cncr.24625","article-title":"Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients","volume":"115","author":"Kelsey","year":"2009","journal-title":"Cancer"},{"key":"10.1097\/JTO.0b013e3182519a42_bib19","series-title":"Modeling Survival Data in Medical Research","author":"Collett","year":"2003"},{"key":"10.1097\/JTO.0b013e3182519a42_bib20","series-title":"Modeling Survival Data","author":"Therneau","year":"2000"},{"key":"10.1097\/JTO.0b013e3182519a42_bib21","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1056\/NEJMoa1006448","article-title":"Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer","volume":"363","author":"Kwak","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1097\/JTO.0b013e3182519a42_bib22","doi-asserted-by":"crossref","first-page":"13306","DOI":"10.1073\/pnas.0405220101","article-title":"EGF receptor gene mutations are common in lung cancers from \u201cnever smokers\u201d and are associated with sensitivity of tumors to gefitinib and erlotinib","volume":"101","author":"Pao","year":"2004","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Thoracic Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086415332913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1556086415332913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T04:24:43Z","timestamp":1542947083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1556086415332913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S1556086415332913"],"URL":"https:\/\/doi.org\/10.1097\/jto.0b013e3182519a42","relation":{},"ISSN":["1556-0864"],"issn-type":[{"value":"1556-0864","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}