{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:05:18Z","timestamp":1747181118535,"version":"3.40.5"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>The aim of this study was to assess whether there is an association between vasectomy and benign prostatic hyperplasia with associated lower urinary tract symptoms (BPH\/LUTS) due to inflammatory etiology.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>We assessed the incidence of BPH\/LUTS in men who had undergone vasectomy in a matched cohort analysis using the TriNetX Research Network. We identified men aged 30 to 60 years who underwent vasectomy and had a follow-up visit within 6 months to 5 years after vasectomy from January 2010 through December 2022 and compared them with matched controls. Outcomes recorded include diagnoses of BPH (N40, N40.1), BPH-related medication prescriptions, and BPH-related procedures. We accounted for confounding variables through propensity score-matching for age; race; and history of comorbid medical conditions: hyperlipidemia (International Classification of Disease-10: E78), metabolic syndrome (E88.81), overweight or obesity (E66), testicular hypofunction (E29.1), hypertension (I10-I16), nicotine dependence (F17), and obstructive sleep apnea (G47.33).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>There was no significant difference in BPH diagnosis between postvasectomy men vs controls (0.84% vs 0.80%, RR: 0.95, 95% CI 0.86-1.05) or BPH\/LUTS diagnosis (0.48% vs 0.44%, RR: 0.92, 95% CI 0.81-1.05) within 6 months to 5 years after vasectomy, respectively. No differences in BPH medication prescription (0.94% vs 0.84%) or rate of BPH procedures (0.022% vs 0.017%) were detected between the 2 groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>This study suggests that vasectomy does not increase the risk of BPH development and\/or LUTS worsening compared with the general population, providing assurance to both patients and health care providers who may consider vasectomy as a safe family planning option.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ju9.0000000000000018","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T09:01:46Z","timestamp":1680598906000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Vasectomy has No Impact on Future Lower Urinary Tract Symptoms Diagnoses: A Retrospective Cohort Claims Database Analysis"],"prefix":"10.1097","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-3236","authenticated-orcid":false,"given":"Greeshma","family":"Venigalla","sequence":"first","affiliation":[{"name":"Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor P.","family":"Kohn","sequence":"additional","affiliation":[{"name":"The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy"},{"name":"University Vita-Salute San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjith","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"issue":"1","key":"R1-20241015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/0970-1591.78440","article-title":"Vasectomy and vasectomy reversal: an update","volume":"27","author":"Schlegel","year":"2011","journal-title":"Indian J Urol."},{"issue":"5","key":"R2-20241015","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.contraception.2011.01.021","article-title":"Contraceptive failure in the United 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