{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:26:33Z","timestamp":1792268793743,"version":"4.4.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>There is conflicting data on the utility of endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) for the detection and subtyping of lymphomas. Herein, we present our experience with EBUS-TBNA in suspected lymphoma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This was a multicenter retrospective study of subjects with suspected lymphoma who underwent EBUS-TBNA (July 2011 to June 2017). The performance characteristics of EBUS-TBNA were calculated separately for suspected new-onset and recurrent lymphoma as well as for subtyping. We also analyzed the factors predicting the yield of EBUS-TBNA in suspected lymphoma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Among the 4803 EBUS procedures performed, 92 (1.9%) subjects had either suspected or proven lymphoma; 48 were finally diagnosed to have lymphoma. The diagnostic sensitivities of EBUS-TBNA in new-onset and recurrent lymphomas were 72.7% and 73.3%, respectively. Only 24.2% (8\/33) subjects with new-onset lymphoma could be appropriately subtyped. This low yield was possibly due to inadequate material for cell block in 10 subjects, and performance of immunophenotyping and flow cytometry in only 5 and 1 subjects, respectively. Among the suspected cases of recurrence, EBUS-TBNA was sufficient for management in 81.8% (18\/22). On a multivariate analysis, no factor (rapid onsite evaluation, needle size, number of lymph nodes sampled, passes per node, and size of the largest lymph node sampled) predicted the diagnostic yield.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>EBUS-TBNA is a useful investigation in the diagnostic algorithm of suspected lymphoma as it helps avoid other invasive diagnostic procedures. The sensitivity of EBUS-TBNA in subtyping new-onset mediastinal lymphoma depends on the adequacy of cell aspirate and the judicious utilization of pathologic techniques.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/lbr.0000000000000552","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T02:29:01Z","timestamp":1540434541000},"page":"199-209","source":"Crossref","is-referenced-by-count":42,"title":["A Multicenter Study on the Utility of EBUS-TBNA and EUS-B-FNA in the Diagnosis of Mediastinal Lymphoma"],"prefix":"10.1097","volume":"26","author":[{"given":"Sahajal","family":"Dhooria","sequence":"first","affiliation":[{"name":"Pulmonary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra M.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Apollo Hospitals, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gella","family":"Vishwanath","sequence":"additional","affiliation":[{"name":"Institute of Pulmonary Medicine and Sleep Disorders, Continental Hospitals, Hyderabad, Telangana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderpaul S.","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant N.","family":"Chhajed","sequence":"additional","affiliation":[{"name":"Fortis Hospital, Nanavati Hospital, and Lilavati Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Prakash","sequence":"additional","affiliation":[{"name":"Internal Medicine, Clinical Hematology and Bone Marrow Transplant Division"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Gupta","sequence":"additional","affiliation":[{"name":"Cytology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanjit","family":"Bal","sequence":"additional","affiliation":[{"name":"Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230927","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1378\/chest.126.1.122","article-title":"Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes","volume":"126","author":"Yasufuku","year":"2004","journal-title":"Chest"},{"key":"R2-20230927","doi-asserted-by":"crossref","first-page":"1393.e1391","DOI":"10.1016\/j.jtcvs.2011.08.037","article-title":"A prospective controlled trial of endobronchial ultrasound-guided transbronchial needle aspiration compared with mediastinoscopy for mediastinal lymph node staging of lung cancer","volume":"142","author":"Yasufuku","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"R3-20230927","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1097\/JTO.0b013e318223c3fe","article-title":"Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study","volume":"6","author":"Navani","year":"2011","journal-title":"J Thorac Oncol"},{"key":"R4-20230927","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1378\/chest.13-2339","article-title":"Endobronchial ultrasound-guided transbronchial needle aspiration vs conventional transbronchial needle aspiration in the diagnosis of sarcoidosis","volume":"146","author":"Gupta","year":"2014","journal-title":"Chest"},{"key":"R5-20230927","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/LBR.0000000000000080","article-title":"Initial experience with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) from a tuberculosis endemic population","volume":"21","author":"Madan","year":"2014","journal-title":"J Bronchology Interv Pulmonol"},{"key":"R6-20230927","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1309\/0Q7F-QTGM-6DPD-TLGY","article-title":"Diagnosis and subclassification of primary and recurrent lymphoma. 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