{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:30:56Z","timestamp":1779917456170,"version":"3.53.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Spontaneous bacterial peritonitis (SBP) is a well-recognized clinical entity with a poor prognosis. In comparison, the prevalence, microbiological flora, and prognostic significance of bacterascites (BA) (the presence of organism on culture but ascitic PMN &lt;250 cells\/mm\u00b3) is largely unknown. We, therefore, assessed the prognosis and predictors of outcome in patients with BA in comparison with those with SBP. Ascitic fluid cultures from consecutive patients with cirrhosis from 2008 to 2018 were reviewed retrospectively, and patients with SBP and BA were identified. Baseline demographic, laboratory, and microbiological data were collated and analyzed as prognostic indicators, and clinical outcomes were recorded. Patients were censored at the time of LT, death, or last follow-up. For this study 176 and 213 cases of SBP and BA, respectively, were identified and included. Patients with SBP had significantly higher Model for End-Stage Liver Disease (MELD) (<jats:italic toggle=\"yes\">p<\/jats:italic>=&lt;0.01), peripheral blood WCC (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.01), and higher rates of Enterobacteriaceae (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.01) and multi-drug resistant pathogens (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.01). Survival at 1 and 3 months was lower in patients with SBP (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; 0.01) when compared with BA but at 6 months and beyond, no significant difference remained. After the exclusion of deaths within 30 days of presentation, survival between SBP and BA was equivocal at all time points. Mortality was substantially higher across all MELD groupings for both SBP and BA when compared with the predicted mortality calculated by the MELD score alone. BA has a negative impact on patient survival above that predicted by the MELD score. It has similar impact to SBP on patient survival beyond 1 month suggesting it should be seen as a poor prognostic marker and prompt consideration of LT where appropriate. Further studies evaluating the role of secondary prophylaxis in this group are required.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/lvt.0000000000000068","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T06:00:55Z","timestamp":1674540055000},"page":"356-364","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Bacterascites confers poor patient prognosis beyond MELD prediction"],"prefix":"10.1097","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-5029","authenticated-orcid":false,"given":"Ji 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