{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:17:26Z","timestamp":1791393446466,"version":"4.3.3"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1097\/maj.0b013e31819299fa","type":"journal-article","created":{"date-parts":[[2009,6,10]],"date-time":"2009-06-10T07:30:14Z","timestamp":1244619014000},"page":"407-410","source":"Crossref","is-referenced-by-count":30,"title":["Chin Numbness: A Symptom That Should Not be Underestimated: A Review of 12 Cases"],"prefix":"10.1016","volume":"337","author":[{"given":"Giuseppe","family":"Colella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amerigo","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Falcone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Siniscalchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Guastafierro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/MAJ.0b013e31819299fa_bb0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1098\/rstl.1829.0029","article-title":"On the nerves of the face: being a second paper on that subject","volume":"119","author":"Bell","year":"1829","journal-title":"Philos Trans R Soc London"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0010","series-title":"The nervous system of the human body","first-page":"64","author":"Bell","year":"1830"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0015","first-page":"148","article-title":"Sur un signe pr\u00e9coce de certaines ost\u00e9ites du maxillaire inf\u00e9rieur se terminant par une n\u00e9crose","volume":"6","author":"Vincent","year":"1896","journal-title":"Revue Trimestrielle Suisse d\u2019Odontologie"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.14219\/jada.archive.1980.0074","article-title":"Dysesthesia after mandibular third molar surgery: a retrospective study and analysis of 1377 surgical procedures","volume":"100","author":"Kipp","year":"1980","journal-title":"J Am Dent Assoc"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0025","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1016\/j.tripleo.2007.11.014","article-title":"Numb chin syndrome: a nonmetastatic neurological manifestation of malignancy","volume":"105","author":"Smith","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0030","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1040-8428(00)00050-0","article-title":"Mental neuropathy: report of five cases and review of the literature","volume":"34","author":"Laurencet","year":"2000","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0035","first-page":"452","article-title":"Numb chin syndrome: a reflection of systemic malignancy","author":"Baskaran","year":"2006","journal-title":"World J Surg Oncol"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0040","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/1097-0142(19920815)70:4<877::AID-CNCR2820700425>3.0.CO;2-G","article-title":"Mental neuropathy (numb chin syndrome): a harbinger of tumor progression or relapse","volume":"70","author":"Burt","year":"1992","journal-title":"Cancer"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0045","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1212\/WNL.42.6.1181","article-title":"Numb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance","volume":"42","author":"Lossos","year":"1992","journal-title":"Neurology"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0050","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1001\/archinte.164.12.1347","article-title":"The numb chin syndrome: a critical sign for primary care physicians","volume":"164","author":"Sweet","year":"2004","journal-title":"Arch Intern Med"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0055","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0278-2391(92)90504-S","article-title":"Mental neuropathy as a sign of distant malignancy: report of cases","volume":"50","author":"Eppley","year":"1992","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0060","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/annonc\/mdn027","article-title":"NCS as the presenting symptom of carcinomatous meningitis","volume":"19","author":"Biasotto","year":"2008","journal-title":"Ann Oncol"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0065","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2214\/ajr.168.2.9016210","article-title":"CT imaging of mental nerve neuropathy: the numb chin syndrome","volume":"168","author":"Bar-Ziv","year":"1997","journal-title":"AJR Am J Roentgenol"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0070","first-page":"86","article-title":"Numb chin syndrome","volume":"67","author":"Maillefert","year":"2000","journal-title":"Joint Bone Spine"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0030-4220(80)90025-0","article-title":"Mental nerve neuropathy: a complication of sickle-cell crisis","volume":"49","author":"Friedlander","year":"1980","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0080","first-page":"855","article-title":"Mental nerve neuropathy in Lyme disease","volume":"64","author":"Maillefert","year":"1997","journal-title":"Rev Rhum Engl Ed"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1055\/s-2008-1017477","article-title":"Numb chin syndrome: first presenting syndrome of multiple sclerosis?","volume":"133","author":"Oestmann","year":"2008","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0090","first-page":"624","article-title":"Numb chin syndrome: a case report","volume":"11","author":"Sebor","year":"1990","journal-title":"Compendium"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0095","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1212\/WNL.50.2.511","article-title":"Numb chin syndrome as the initial manifestation of HIV infection","volume":"50","author":"Benito-Leon","year":"1998","journal-title":"Neurology"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0100","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0030-4220(82)90343-7","article-title":"Systemic sarcoidosis presenting with Horner\u2019s syndrome and mandibular paresthesia","volume":"53","author":"Cohen","year":"1982","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0105","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1673::AID-MUS8>3.0.CO;2-A","article-title":"Mandibular nerve involvement in diabetic polyneuropathy and chronic inflammatory demyelinating polyneuropathy","volume":"21","author":"Cruccu","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0110","series-title":"Hand-book of clinical neurology 51","first-page":"444","article-title":"Angiopatic neuropathy in collagen vascular disease","author":"Bruyn","year":"1987"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1212\/WNL.21.6.609","article-title":"Trigeminal neuropathy in connective tissue disease","volume":"21","author":"Ashworth","year":"1971","journal-title":"Neurology"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0120","first-page":"1425","article-title":"Numb chin syndrome as first sign of temporal arteritis","volume":"26","author":"Genereau","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0125","first-page":"E141","article-title":"Multiple sclerosis as first manifestation in oral and facial area: presentation of four cases","volume":"11","author":"Gallud","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0130","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0733-8619(02)00030-0","article-title":"Neurologic complications of hematologic neoplasms","volume":"21","author":"Recht","year":"2003","journal-title":"Neurol Clin"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0135","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0090-4295(99)00396-9","article-title":"Numb chin syndrome as the presenting symptom of metastatic prostate carcinoma","volume":"55","author":"Halachmi","year":"2000","journal-title":"Urology"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1464-410x.2000.00494.x","article-title":"Numb chin syndrome: an unusual presentation of metastatic prostate cancer","volume":"85","author":"Thompson","year":"2000","journal-title":"BJU Int"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0145","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1532-5415.2008.01599.x","article-title":"Metastatic prostate carcinoma presenting as NCS in elderly people","volume":"56","author":"Requena","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0150","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/sj.gt.3302950","article-title":"Gene transfer to interfere with TNFalpha signaling in neuropathic pain","volume":"14","author":"Hao","year":"2007","journal-title":"Gene Ther"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/1098-1136(200010)32:1<42::AID-GLIA40>3.0.CO;2-3","article-title":"Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head","volume":"32","author":"Yuan","year":"2000","journal-title":"Glia"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0160","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1016\/j.tripleo.2007.11.014","article-title":"Numb chin syndrome: a nonmetastatic neurological manifestation of malignancy","volume":"105","author":"Smith","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hed.2880150102","article-title":"DentaScan imaging of the mandible and maxilla","volume":"15","author":"Yanagisawa","year":"1993","journal-title":"Head Neck"},{"key":"10.1097\/MAJ.0b013e31819299fa_bb0170","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archotol.129.1.113","article-title":"Dentascan as an accurate method of predicting mandibular invasion in patients with squamous cell carcinoma of the oral cavity","volume":"129","author":"Brockenbrough","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962915319650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962915319650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T20:30:02Z","timestamp":1558384202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962915319650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0002962915319650"],"URL":"https:\/\/doi.org\/10.1097\/maj.0b013e31819299fa","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}