{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:28:59Z","timestamp":1777627739696,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of the Medical Sciences"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1097\/maj.0b013e3181b27195","type":"journal-article","created":{"date-parts":[[2009,10,8]],"date-time":"2009-10-08T07:29:26Z","timestamp":1254986966000},"page":"301-309","source":"Crossref","is-referenced-by-count":20,"title":["Effect of the HMG-CoA Reductase Inhibitor Rosuvastatin on Early Chronic Kidney Injury in Obese Zucker Rats Fed With an Atherogenic Diet"],"prefix":"10.1016","volume":"338","author":[{"given":"Efrain","family":"Reisin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Larroque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin A.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Ebenezer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Francis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1097\/MAJ.0b013e3181b27195_bb0005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00000441-200512000-00003","article-title":"Definition of the metabolic syndrome: current proposals and controversies","volume":"330","author":"Reisin","year":"2005","journal-title":"Am J Med Sci"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0010","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1006\/bbrc.1996.1070","article-title":"Substitution at codon 269 (glutamine \u2013> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa\/fa) rat","volume":"224","author":"Iida","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0015","doi-asserted-by":"crossref","first-page":"I110","DOI":"10.1161\/01.HYP.19.1_Suppl.I110","article-title":"The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury","volume":"19","author":"Kasiske","year":"1992","journal-title":"Hypertension"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1523-1755.2000.00836.x","article-title":"Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes","volume":"57","author":"Coimbra","year":"2000","journal-title":"Kidney Int"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/jn\/132.2.231","article-title":"Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet","volume":"132","author":"Vaskonen","year":"2002","journal-title":"J Nutr"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0030","first-page":"5937","article-title":"Effects of dehydroepiandrosterone and quinapril on nephropathy in obese Zucker rats","author":"Richards","year":"2001","journal-title":"Kidney Int"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0272-6386(12)70172-5","article-title":"Lovastatin retards the progression of established glomerular disease in obese Zucker rats","volume":"22","author":"O\u2019Donnell","year":"1993","journal-title":"Am J Kidney Dis"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0040","first-page":"598","article-title":"Effects of genetic obesity on renal structure and function in the Zucker rat","volume":"106","author":"Kasiske","year":"1985","journal-title":"J Lab Clin Med"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0045","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0361-9230(85)90113-3","article-title":"Patterns of hyperphagia in the Zucker obese rat: a role for fat cell size and number?","volume":"14","author":"Vasselli","year":"1985","journal-title":"Brain Res Bull"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0050","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.metabol.2003.10.027","article-title":"Attenuation of hyperinsulinemia by NN414, a SUR1\/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats","volume":"53","author":"Alemzadeh","year":"2004","journal-title":"Metabolism"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0055","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1210\/en.2003-0870","article-title":"Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome","volume":"144","author":"Unger","year":"2003","journal-title":"Endocrinology"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0060","doi-asserted-by":"crossref","first-page":"12307","DOI":"10.1128\/JVI.01002-07","article-title":"Infection of cardiomyocytes and induction of left ventricle dysfunction by neurovirulent polytropic murine retrovirus","volume":"81","author":"Khaleduzzaman","year":"2007","journal-title":"J Virol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0065","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/HYPERTENSIONAHA.108.124149","article-title":"Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker rat","volume":"53","author":"Osmond","year":"2009","journal-title":"Hypertension"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0070","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0272-6386(95)90112-4","article-title":"Tubulointerstitial lesions in young Zucker rats","volume":"25","author":"Magil","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0075","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1097\/01.ASN.0000141965.28037.EE","article-title":"Obesity-initiated metabolic syndrome and the kidney: a recipe for chronic kidney disease?","volume":"15","author":"Bagby","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0080","doi-asserted-by":"crossref","first-page":"F262","DOI":"10.1152\/ajprenal.00099.2005","article-title":"Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences","volume":"290","author":"Vaziri","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0085","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00004872-198708000-00002","article-title":"Renal haemodynamic studies in obesity hypertension","volume":"5","author":"Reisin","year":"1987","journal-title":"J Hypertens"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0090","doi-asserted-by":"crossref","first-page":"F817","DOI":"10.1152\/ajprenal.2000.278.5.F817","article-title":"Glomerular hemodynamics in severe obesity","volume":"278","author":"Chagnac","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0095","doi-asserted-by":"crossref","first-page":"49S","DOI":"10.1016\/S0895-7061(97)00075-7","article-title":"Mechanisms of abnormal renal sodium handling in obesity hypertension","volume":"10","author":"Hall","year":"1997","journal-title":"Am J Hypertens"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0100","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1210\/jc.2004-1174","article-title":"Obesity-related glomerulopathy","volume":"89","author":"Tran","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00041552-200303000-00011","article-title":"Obesity-associated hypertension and kidney disease","volume":"12","author":"Hall","year":"2003","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0110","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/01.HYP.23.3.381","article-title":"Louis K. Dhal Memorial Lecture. Renal and cardiovascular mechanisms of hypertension in obesity","volume":"23","author":"Hall","year":"1994","journal-title":"Hypertension"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0115","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1053\/ajkd.2001.28620","article-title":"Obesity and the kidney connection","volume":"38","author":"Reisin","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0120","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00000441-200512000-00010","article-title":"Kidney disease and the metabolic syndrome","volume":"330","author":"Zhang","year":"2005","journal-title":"Am J Med Sci"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0125","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1210\/rp.59.1.169","article-title":"Hypertension and obesity","volume":"59","author":"Aneja","year":"2004","journal-title":"Recent Prog Horm Res"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0130","doi-asserted-by":"crossref","first-page":"H1597","DOI":"10.1152\/ajpheart.00026.2004","article-title":"Insulin resistance and hypertension","volume":"286","author":"Sowers","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/ajkd.2002.29865","article-title":"Leptin and renal disease","volume":"39","author":"Wolf","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0140","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1210\/jc.2002-020298","article-title":"Atorvastatin reduces postprandial accumulation and cholesteryl ester transfer protein-mediated remodeling of triglyceride-rich lipoprotein subspecies in type IIb hyperlipidemia","volume":"87","author":"Guerin","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0145","first-page":"358","article-title":"Beneficial effects of atorvastatin in the treatment of hyperlipidemia after renal transplantation","volume":"112","author":"Demetriou","year":"2000","journal-title":"Wien Klin Wochenschr"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0150","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1172\/JCI115089","article-title":"Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation","volume":"87","author":"Johnson","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0155","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/01.fjc.0000210072.48991.f6","article-title":"Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats","volume":"47","author":"Loch","year":"2006","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0160","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1524-6175.2007.06625.x","article-title":"Statins and blood pressure: is there an effect or not?","volume":"9","author":"Sarafidis","year":"2007","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0165","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/01.HYP.0000259737.43916.42","article-title":"Do statins reduce blood pressure?: a meta-analysis of randomized, controlled trials","volume":"49","author":"Strazzullo","year":"2007","journal-title":"Hypertension"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0170","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.amjcard.2005.12.052","article-title":"Effect of short-term rosuvastatin treatment on estimated glomerular filtration rate","volume":"97","author":"Vidt","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0175","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.ajkd.2008.05.027","article-title":"Progression of kidney disease in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin versus usual care: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)","volume":"52","author":"Rahman","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0180","doi-asserted-by":"crossref","first-page":"117","DOI":"10.7326\/0003-4819-145-2-200607180-00009","article-title":"Meta-analysis: the effect of statins on albuminuria","volume":"145","author":"Douglas","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0185","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2353\/ajpath.2007.060882","article-title":"Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats","volume":"170","author":"Gianella","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0190","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1053\/ajkd.2003.50140","article-title":"A controlled, prospective study of the effects of atorvastatin on proteinuria and progression of kidney disease","volume":"41","author":"Bianchi","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0195","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1177\/0091270006292629","article-title":"Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia","volume":"46","author":"Kostapanos","year":"2006","journal-title":"J Clin Pharmacol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0200","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/sj.ki.5002174","article-title":"HMG-CoA reductase inhibitors and the kidney","volume":"71","author":"Campese","year":"2007","journal-title":"Kidney Int"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0205","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/153857440303700501","article-title":"Noncholesterol-lowering effects of statins","volume":"37","author":"Pierre-Paul","year":"2003","journal-title":"Vasc Endovascular Surg"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0210","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/HYPERTENSIONAHA.107.102467","article-title":"Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment","volume":"51","author":"Whaley-Connell","year":"2008","journal-title":"Hypertension"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0215","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/01.ATV.0000157145.98200.55","article-title":"Rosuvastatin, but not Simvastatin, provides end-organ protection in stroke-prone rats by antiinflammatory effects","volume":"25","author":"Sironi","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1097\/MAJ.0b013e3181b27195_bb0220","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0735-1097(03)00926-4","article-title":"Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models","volume":"42","author":"Susic","year":"2003","journal-title":"J Am Coll Cardiol"}],"container-title":["The American Journal of the Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962915318012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002962915318012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T02:42:16Z","timestamp":1685155336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002962915318012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0002962915318012"],"URL":"https:\/\/doi.org\/10.1097\/maj.0b013e3181b27195","relation":{},"ISSN":["0002-9629"],"issn-type":[{"value":"0002-9629","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}