{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:04:51Z","timestamp":1792713891226,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1097\/mao.0b013e31815d4429","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T06:30:17Z","timestamp":1236234617000},"page":"50-57","source":"Crossref","is-referenced-by-count":55,"title":["ErbB and Nrg"],"prefix":"10.1097","volume":"29","author":[{"given":"Joni K.","family":"Doherty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weg","family":"Ongkeko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Crawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Andalibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen F.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20221010","first-page":"722","article-title":"Conservative management of unilateral acoustic neuromas.","volume":"21","author":"Taschudi","year":"2000","journal-title":"Am J Otol"},{"key":"R2-12-20221010","first-page":"312","article-title":"Results and complications from acoustic neuroma excision via middle cranial fossa approach.","volume":"17","author":"Weber","year":"1996","journal-title":"Am J Otol"},{"key":"R3-12-20221010","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/00005537-199606000-00007","article-title":"Growth rate characteristics of acoustic neuromas associated with neurofibromatosis type 2.","volume":"106","author":"Abaza","year":"1996","journal-title":"Laryngoscope"},{"key":"R4-12-20221010","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00129492-200403000-00012","article-title":"Hearing changes after diagnosis in Neurofibromatosis type 2.","volume":"25","author":"Masuda","year":"2004","journal-title":"Otol Neurotol"},{"key":"R5-12-20221010","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1136\/jmg.40.11.802","article-title":"Identification of recurrent regions of chromosome loss and gain in vestibular schwannomas using comparative genomic hybridisation.","volume":"40","author":"Warren","year":"2003","journal-title":"J Med Genet"},{"key":"R6-12-20221010","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/363515a0","article-title":"Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2.","volume":"363","author":"Rouleau","year":"1993","journal-title":"Nature"},{"key":"R7-12-20221010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/hmg\/3.1.147","article-title":"The neurofibromatosis type 2 gene is inactivated in schwannomas.","volume":"3","author":"Twist","year":"1994","journal-title":"Hum Molec Genet"},{"key":"R8-12-20221010","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ng930","article-title":"Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.","volume":"31","author":"Fernandez-Valle","year":"2002","journal-title":"Nat Genet"},{"key":"R9-12-20221010","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0896-6273(95)90147-7","article-title":"Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors.","volume":"15","author":"Dong","year":"1995","journal-title":"Neuron"},{"key":"R10-12-20221010","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1126\/science.1095862","article-title":"Axonal neuregulin-1 regulates myelin sheath thickness.","volume":"304","author":"Michailov","year":"2004","journal-title":"Science"},{"key":"R11-12-20221010","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1523\/JNEUROSCI.20-12-04635.2000","article-title":"Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity.","volume":"20","author":"Maurel","year":"2000","journal-title":"J Neurosci"},{"key":"R12-12-20221010","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1523\/JNEUROSCI.15-02-01329.1995","article-title":"The influence of heregulins on human Schwann cell proliferation.","volume":"15","author":"Levi","year":"1995","journal-title":"J Neurosci"},{"key":"R13-12-20221010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/01.jnen.0000199575.93794.2f","article-title":"Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis.","volume":"65","author":"Stonecypher","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"R14-12-20221010","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/glia.20316","article-title":"Constitutive neuregulin-1\/ErbB signaling contributes to human vestibular schwannoma proliferation.","volume":"53","author":"Hansen","year":"2006","journal-title":"Glia"},{"key":"R16-12-20221010","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/319230a0","article-title":"Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor.","volume":"319","author":"Yamamoto","year":"1986","journal-title":"Nature"},{"key":"R17-12-20221010","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0896-6273(00)80324-4","article-title":"Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis.","volume":"18","author":"Burden","year":"1997","journal-title":"Neuron"},{"key":"R18-12-20221010","first-page":"165","article-title":"The biology of erbB-2\/neu\/HER-2 and its role in cancer.","volume":"1198","author":"Hynes","year":"1994","journal-title":"Biochem Biophys Acta"},{"key":"R19-12-20221010","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.96.19.10869","article-title":"The HER-2\/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor.","volume":"96","author":"Doherty","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"R20-12-20221010","doi-asserted-by":"crossref","first-page":"20618","DOI":"10.1074\/jbc.M111359200","article-title":"Herstatin, an autoinhibitor of the human epidermal growth factor receptor 2 tyrosine kinase, modulates epidermal growth factor signaling pathways resulting in growth arrest.","volume":"277","author":"Justman","year":"2002","journal-title":"J Biol Chem"},{"key":"R21-12-20221010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00005537-199604000-00012","article-title":"Epidermal growth factor receptor expression by acoustic neuromas.","volume":"106","author":"Sturgis","year":"1996","journal-title":"Laryngoscope"},{"key":"R22-12-20221010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ccr.2004.10.016","article-title":"Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.","volume":"7","author":"Ling","year":"2005","journal-title":"Cancer Cell"},{"key":"R23-12-20221010","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1101\/gad.13.8.978","article-title":"Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein.","volume":"13","author":"Giovannini","year":"1999","journal-title":"Genes Dev"},{"key":"R24-12-20221010","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00280-005-0070-z","article-title":"A phase II, open-label study of gefitinib (IRESSA) in patients with locally advanced, metastatic, or relapsed renal-cell carcinoma.","volume":"57","author":"Jermann","year":"2006","journal-title":"Cancer Chemother Pharmacol"},{"key":"R25-12-20221010","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1093\/annonc\/12.suppl_1.S63","article-title":"Tolerability in patients receiving trastuzumab with or without chemotherapy.","volume":"12","author":"Gianni","year":"2001","journal-title":"Ann Oncol"},{"key":"R26-12-20221010","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1158\/0008-5472.CAN-05-3387","article-title":"Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors.","volume":"66","author":"Amin","year":"2006","journal-title":"Cancer Res"},{"key":"R27-12-20221010","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1200\/JCO.2005.08.037","article-title":"Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.","volume":"23","author":"Chung","year":"2005","journal-title":"J Clin Oncol"}],"container-title":["Otology & Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00129492-200801000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T05:02:07Z","timestamp":1665378127000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00129492-200801000-00012"}},"subtitle":["Potential Molecular Targets for Vestibular Schwannoma Pharmacotherapy"],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/mao.0b013e31815d4429","relation":{},"ISSN":["1531-7129"],"issn-type":[{"value":"1531-7129","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}