{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:14:44Z","timestamp":1786119284856,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1097\/mao.0b013e3181c0eaba","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T08:38:14Z","timestamp":1261039094000},"page":"153-156","source":"Crossref","is-referenced-by-count":8,"title":["Endogenous Ouabain in M\u00e9ni\u00e8re's Disease"],"prefix":"10.1097","volume":"31","author":[{"given":"Roberto","family":"Teggi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zagato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Delli Carpini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Messaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzia","family":"Casamassima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lanzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Manunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Bussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-26-20210212","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","article-title":"Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?","volume":"26","author":"Merchant","year":"2005","journal-title":"Otol Neurotol"},{"key":"R2-26-20210212","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1098\/rspb.1968.0066","article-title":"Observations on the electrochemistry of the cochlear endolymph of the rat: a quantitative study of its electrical potential and ionic composition as determined by means of flame spectrophotometry.","volume":"171","author":"Bosher","year":"1968","journal-title":"Proc R Soc Lond B"},{"key":"R3-26-20210212","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1288\/00005537-198708000-00020","article-title":"Mechanisms of endocochlear potential generation by stria vascularis.","volume":"97","author":"Salt","year":"1987","journal-title":"Laryngoscope"},{"key":"R4-26-20210212","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/37.2.2536055","article-title":"Distribution of immunoreactive Na+,K+-ATPase in gerbil cochlea.","volume":"37","author":"Schulte","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"R5-26-20210212","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0378-5955(90)90229-I","article-title":"Immunolocalization of Na+, K+-ATPase and carbonic anhydrase in the gerbil's vestibular system.","volume":"43","author":"Spicer","year":"1990","journal-title":"Hear Res"},{"key":"R6-26-20210212","first-page":"123","article-title":"Immunohistochemical localization of the Na+, K+-ATPase in the endolymphatic sac.","volume":"42","author":"Yamane","year":"1988","journal-title":"Adv Otorhinolaryngol"},{"key":"R7-26-20210212","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-5955(02)00352-0","article-title":"Sodium- and potassium- activated ATPase in the mammalian vestibular system.","volume":"171","author":"Pitovski","year":"2002","journal-title":"Hear Res"},{"key":"R8-26-20210212","first-page":"825","article-title":"On the determination of ouabain in Acokanthera abyssinica seeds.","volume":"103","author":"Menziani","year":"1964","journal-title":"Boll Chim Farm"},{"key":"R9-26-20210212","first-page":"413","article-title":"Ouabain is secreted by the adrenal gland in awake dogs.","volume":"264","author":"Boulanger","year":"1993","journal-title":"Am J Physiol"},{"key":"R10-26-20210212","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/CIRCULATIONAHA.105.554071","article-title":"Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal.","volume":"112","author":"Murrell","year":"2005","journal-title":"Circulation"},{"key":"R11-26-20210212","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1373\/clinchem.2003.029017","article-title":"Biosynthesis of endogenous cardiac glycosides by mammalian adrenocortical cells: three steps forward.","volume":"50","author":"Hamlyn","year":"2004","journal-title":"Clin Chem"},{"key":"R12-26-20210212","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/ajpregu.00648.2005","article-title":"Salt intake and depletion increase circulating levels of endogenous ouabain in normal men.","volume":"290","author":"Manunta","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R13-26-20210212","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/00016487009123353","article-title":"Effect of ouabain on cochlear potentials and endolymph composition in guinea pigs.","volume":"69","author":"Konishi","year":"1970","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"R14-26-20210212","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0378-5955(95)00009-S","article-title":"Ion transport mechanisms responsible for K+ secretion and the transepithelial voltage across marginal cells of stria vascularis in vitro.","volume":"84","author":"Wangemann","year":"1995","journal-title":"Hear Res"},{"key":"R15-26-20210212","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/00016488009131718","article-title":"The effect of inhibition of the strial Na+, K+ activated ATPase by perilymphatic ouabain in the guinea pig.","volume":"90","author":"Bosher","year":"1980","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"R16-26-20210212","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1080\/00016489950180423","article-title":"Morphological changes induced by administration of a Na+, K+-ATPase inhibitor in normal and hydropic inner ears of the guinea pig.","volume":"119","author":"Hamada","year":"1999","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"R17-26-20210212","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10162-004-5021-6","article-title":"Ouabain induces apoptotic cell death in type I spiral ganglion neurons, but not in type II neurons.","volume":"6","author":"Lang","year":"2005","journal-title":"J Assoc Res Otolaryngol"},{"key":"R18-26-20210212","first-page":"1338","article-title":"Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension.","volume":"277","author":"Ferrandi","year":"1999","journal-title":"Am J Physiol"},{"key":"R19-26-20210212","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/MAO.0b013e318180a4b1","article-title":"Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Meniere's syndrome.","volume":"29","author":"Teggi","year":"2008","journal-title":"Otol Neurotol"},{"key":"R20-26-20210212","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/00004872-200308000-00010","article-title":"Salt, endogenous ouabain and blood pressure interactions in the general population.","volume":"21","author":"Wang","year":"2003","journal-title":"J Hypertens"},{"key":"R21-26-20210212","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Guidelines for the diagnosis and evaluation of therapy in Meniere's disease.","volume":"113","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R22-26-20210212","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/01.HYP.30.4.886","article-title":"Ouabain-like factor quantification in mammalian tissues and plasma: comparison of two independent assays.","volume":"30","author":"Ferrandi","year":"1997","journal-title":"Hypertension"},{"key":"R23-26-20210212","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0378-5955(84)90224-7","article-title":"Water permeability of the endolymph-perilymph barrier in the guinea pig cochlea.","volume":"15","author":"Konishi","year":"1984","journal-title":"Hear Res"},{"key":"R24-26-20210212","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1113\/jphysiol.1971.sp009354","article-title":"A study of the electrochemistry and osmotic relationship of the cochlear fluids in the neonatal rat at the time of the development of the endocochlear potential.","volume":"212","author":"Bosher","year":"1971","journal-title":"J Physiol"},{"key":"R25-26-20210212","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-5955(96)00154-2","article-title":"Effects of aging on potassium homeostasis and the endocochlear potential in the gerbil cochlea.","volume":"102","author":"Schmiedt","year":"1996","journal-title":"Hear Res"},{"key":"R26-26-20210212","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1152\/ajpcell.00024.2007","article-title":"Functional significance of channels and transporters expressed in the inner ear and kidney.","volume":"293","author":"Lang","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"R27-26-20210212","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1113\/jphysiol.2006.112888","article-title":"Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential.","volume":"576","author":"Wangemann","year":"2006","journal-title":"J Physiol"},{"key":"R28-26-20210212","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0092-8674(01)00241-0","article-title":"Molecular mechanisms of human hypertension.","volume":"104","author":"Lifton","year":"2001","journal-title":"Cell"},{"key":"R29-26-20210212","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1681\/ASN.2006010086","article-title":"Ouabain binds with high affinity to the Na, K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation.","volume":"18","author":"Nguyen","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R30-26-20210212","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/HJH.0b013e3282f5315f","article-title":"Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension.","volume":"26","author":"Manunta","year":"2008","journal-title":"J Hypertens"},{"key":"R31-26-20210212","first-page":"325","article-title":"P-type ATPase diversity and evolution: the origins of ouabain sensitivity and subunit assembly.","volume":"47","author":"Takeyasu","year":"2001","journal-title":"Cell Mol Biol"},{"key":"R32-26-20210212","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1074\/jbc.M609872200","article-title":"FXYD6 is a novel regulator of Na, K-ATPase expressed in the inner ear.","volume":"282","author":"Delprat","year":"2007","journal-title":"J Biol Chem"},{"key":"R33-26-20210212","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1124\/mi.3.3.157","article-title":"Na+, K+-ATPase-mediated signal transduction: from protein interaction to cellular function.","volume":"3","author":"Xie","year":"2003","journal-title":"Mol Interv"}],"container-title":["Otology &amp; Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MAO.0b013e3181c0eaba","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:11:05Z","timestamp":1786039865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00129492-201001000-00026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/mao.0b013e3181c0eaba","relation":{},"ISSN":["1531-7129"],"issn-type":[{"value":"1531-7129","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}