{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:34:07Z","timestamp":1788834847230,"version":"build-2803163510"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Since the first successful case report in 1972, extracorporeal life support or extracorporeal membrane oxygenation (ECMO) has become a standard approach for severe respiratory failure unresponsive to other therapy. In the past, if there was no recovery by approximately 30 days or if right ventricular heart failure occurred, ECMO was discontinued and the patient died. More recently patients with severe lung disease have been maintained for months, as opposed to days, with eventual decannulation and recovery. We report the case of a child, 7 years old, with severe inhalational burn injury and rapid progression to multisystem organ failure. She was supported by ECMO with no lung function for almost 2 years. Central nervous system function remained normal and lung function recovered. This is the longest successful case of ECMO to date and prompts further discussion regarding \u201cirreversible\u201d lung injury.<\/jats:p>","DOI":"10.1097\/mat.0000000000000990","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T14:58:31Z","timestamp":1553612311000},"page":"e11-e14","source":"Crossref","is-referenced-by-count":27,"title":["Recovery from Total Acute Lung Failure After 20 Months of Extracorporeal Life Support"],"prefix":"10.1097","volume":"66","author":[{"given":"Kristen","family":"Nelson-McMillan","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Anesthesiology and Critical Care Medicine, Division of Pediatric Critical Care"},{"name":"Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca A.","family":"Vricella","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Surgery, Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fray Dylan","family":"Stewart","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Surgery, Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Division of Pediatric General Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pediatric ECMO and VAD program, Johns Hopkins Hospital, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narutoshi","family":"Hibino","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Surgery, Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Division of Pediatric Cardiothoracic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Coulson","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, Maryland"},{"name":"Department of Pediatrics"},{"name":"Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230928","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1056\/NEJM197203232861204","article-title":"Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure (shock-lung syndrome). 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