{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:41:40Z","timestamp":1787010100024,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    The prophylactic use of amiodarone to reduce the incidence of postoperative arrhythmias is effective for patients undergoing general cardiac surgeries; however, no data exists for the use of prophylactic amiodarone to prevent postoperative arrhythmias after CF-LVAD. This single-center, retrospective analysis compared patients with CF-LVADs placed between April 2014 and June 2020 who received prophylactic postoperative amiodarone to those who did not. Based on institution practice at the respective times, patients with a CF-LVAD placed between April 2014 and June 2018 were included in the group receiving postoperative amiodarone arrhythmia prophylaxis and patients with a CF-LVAD placed July 2018 to June 2020 were included in the group not receiving arrhythmia prophylaxis. The primary outcome was the incidence of first occurring atrial or ventricular arrhythmia from CF-LVAD placement to 21 days or hospital discharge. Sixty patients received amiodarone for arrhythmia prophylaxis and 27 patients did not receive prophylaxis. The primary outcome occurred in 40% of the prophylaxis group and 66.7% in the no prophylaxis group (RR, 0.60; 95% CI, 0.40\u20130.90;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.038). In patients receiving CF-LVADs, the use of prophylactic amiodarone was associated with a reduction in the incidence of postoperative arrhythmias, which was driven primarily by a reduction in postoperative atrial arrhythmias, without significantly increasing the rate of amiodarone-related adverse events.\n                  <\/jats:p>","DOI":"10.1097\/mat.0000000000001663","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T23:00:57Z","timestamp":1644188457000},"page":"96-100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Safety and Efficacy of Prophylactic Amiodarone After Left Ventricular Assist Device"],"prefix":"10.1097","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-2472","authenticated-orcid":false,"given":"Sydney D. T.","family":"Graboyes","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina"},{"name":"Department of Pharmacy, University of California, Davis Medical Center, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-5627","authenticated-orcid":false,"given":"Theresa M.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-7983","authenticated-orcid":false,"given":"Taylor N.","family":"Harris","sequence":"additional","affiliation":[{"name":"Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-2451","authenticated-orcid":false,"given":"Prashanth S.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-3706","authenticated-orcid":false,"given":"Ian B.","family":"Hollis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"R1-20250530","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.healun.2015.05.018","article-title":"Early post-operative ventricular arrhythmias in patients with continuous-flow left ventricular assist devices.","volume":"34","author":"Garan","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"R2-20250530","first-page":"168","article-title":"Thirty-five years of mechanical circulatory support at the Texas Heart Institute: an updated overview.","volume":"32","author":"Gemmato","year":"2005","journal-title":"Tex Heart Inst J"},{"key":"R3-20250530","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/CIRCEP.113.000113","article-title":"Ventricular arrhythmias after left ventricular assist device.","volume":"6","author":"Nakahara","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"R4-20250530","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1001\/jama.294.24.3093","article-title":"Prophylactic oral amiodarone for the prevention of arrhythmias that begin early after revascularization, valve replacement, or repair: PAPABEAR: a randomized controlled trial.","volume":"294","author":"Mitchell","year":"2005","journal-title":"JAMA"},{"key":"R5-20250530","doi-asserted-by":"crossref","DOI":"10.33590\/emjcardiol\/10311539","article-title":"A clinical review of ventricular arrhythmias in patients with congestive heart failure [published online ahead of print September 6, 2019].","author":"Al-Hadithi","year":"2019","journal-title":"EMJ Cardiol"},{"key":"R6-20250530","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1016\/j.healun.2017.01.476","article-title":"Postoperative atrial fibrillation after left ventricular assist device placement increases morbidity and resource utilization.","volume":"36","author":"Hawkins","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"R7-20250530","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.hrthm.2016.01.033","article-title":"Predictors and clinical relevance of ventricular tachyarrhythmias in ambulatory patients with a continuous flow left ventricular assist device.","volume":"13","author":"Yoruk","year":"2016","journal-title":"Heart Rhythm"},{"key":"R8-20250530","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MAT.0000000000000763","article-title":"Incidence and outcomes of postoperative atrial fibrillation after left ventricular assist device.","volume":"64","author":"Deshmukh","year":"2018","journal-title":"ASAIO J"}],"container-title":["ASAIO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MAT.0000000000001663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:08:40Z","timestamp":1748596120000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MAT.0000000000001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1097\/mat.0000000000001663","relation":{},"ISSN":["1058-2916"],"issn-type":[{"value":"1058-2916","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}