{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:43:43Z","timestamp":1757450623644,"version":"3.41.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Inherited dysfibrinogenemias are molecular disorders of fibrinogen that affect fibrin polymerization. The majority of cases are asymptomatic, but a significant proportion suffer from increased bleeding or thrombosis. We present two unrelated cases of dysfibrinogenemia, both of whom showed a characteristic discrepancy between fibrinogen activity and the immunologic fibrinogen. In one patient, the dysfibrinogenemia was confirmed by molecular analysis; in the other case, the diagnosis was presumptive based upon laboratory studies. Both patients underwent elective surgery. Both received a highly purified fibrinogen concentrate preoperatively and demonstrated a suboptimal laboratory response to the infusion. Three methods for determining fibrinogen concentration (Clauss fibrinogen, prothrombin-derived fibrinogen, and the viscoelastic functional fibrinogen) were utilized in the case of one patient, and these techniques showed discrepant results with the classic Clauss method giving the lowest concentration. Neither patient experienced excessive bleeding during surgery.<\/jats:p>\n            <jats:p>Although these discrepancies have been previously described in untreated patients, their manifestation after infusion of purified fibrinogen is less well appreciated.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mbc.0000000000001237","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T10:32:55Z","timestamp":1688380375000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Dysfibrinogenemia: discrepant results following infusion of purified fibrinogen"],"prefix":"10.1097","volume":"34","author":[{"given":"Maximo J.","family":"Marin","sequence":"first","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol M.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Rajasekhar","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Zumberg","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy Y.","family":"Euliano","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology"},{"name":"Department of Obstetrics and Gynecology, University of Florida College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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