{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:03:50Z","timestamp":1786118630237,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1097\/mbc.0b013e328040c115","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T05:28:23Z","timestamp":1170826103000},"page":"187-192","source":"Crossref","is-referenced-by-count":34,"title":["Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR)"],"prefix":"10.1097","volume":"18","author":[{"given":"Burak","family":"Pamukcu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Oflaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Onur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytac","family":"Oncul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berrin","family":"Umman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fehmi","family":"Mercanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Meric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilmaz","family":"Nisanci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210203","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/0002-8703(91)90275-M","article-title":"The effect of chronic platelet inhibition with low dose aspirin on atherosclerotic progression and acute thrombosis:clinical evidence from Physicians Health Study","volume":"122","author":"Ridker","year":"1991","journal-title":"Am Heart J"},{"key":"R2-15-20210203","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.308.6921.81","article-title":"Collaborative overview of randomized trials of antiplatelet therapy: I. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients.","volume":"308","year":"1994","journal-title":"BMJ"},{"key":"R3-15-20210203","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0002-9149(01)01631-9","article-title":"Profile and prevalence of aspirin resistance in patients with cardiovascular disease","volume":"88","author":"Gum","year":"2001","journal-title":"Am J Cardiol"},{"key":"R4-15-20210203","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1172\/JCI115032","article-title":"Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes","volume":"87","author":"Santos","year":"1991","journal-title":"J Clin Invest"},{"key":"R5-15-20210203","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0735-1097(03)00921-5","article-title":"Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T (GP Ia\/I\u0131a) and C-5T Kozak (GP Ib\u03b1) polymorphisms","volume":"42","author":"Macchi","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R6-15-20210203","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ahj.2004.10.007","article-title":"The role of platelet glycoprotein IIIa polymorphism in the high prevalence of in vitro aspirin resistance in patients with intracoronary stent restenosis","volume":"149","author":"Pamukcu","year":"2005","journal-title":"Am Heart J"},{"key":"R7-15-20210203","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.amjcard.2004.11.045","article-title":"Aspirin resistance and a single gene","volume":"95","author":"Jefferson","year":"2005","journal-title":"Am J Cardiol"},{"key":"R8-15-20210203","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/01.CIR.96.4.1109","article-title":"Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina pectoris","volume":"96","author":"Cipollone","year":"1997","journal-title":"Circulation"},{"key":"R9-15-20210203","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/hc3401.093152","article-title":"Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability","volume":"104","author":"Cipollone","year":"2001","journal-title":"Circulation"},{"key":"R10-15-20210203","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.CIR.102.8.840","article-title":"Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis","volume":"102","author":"Belton","year":"2000","journal-title":"Circulation"},{"key":"R11-15-20210203","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/01.CIR.89.5.1951","article-title":"Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin","volume":"89","author":"Larsson","year":"1994","journal-title":"Circulation"},{"key":"R12-15-20210203","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11239-005-2318-1","article-title":"The role of exercise on platelet aggregation in patients with stable coronary artery disease: exercise induces aspirin resistant platelet activation","volume":"20","author":"Pamukcu","year":"2005","journal-title":"J Thromb Thrombolysis"},{"key":"R13-15-20210203","first-page":"479","article-title":"Cigarette smoking-induced enhancement of platelet function: lack of prevention by aspirin in men with coronary artery disease","volume":"105","author":"Davis","year":"1985","journal-title":"J Lab Clin Med"},{"key":"R14-15-20210203","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/01.STR.31.3.591","article-title":"Increased platelet sensitivity to collagen in individuals resistant to low-dose aspirin","volume":"31","author":"Kawasaki","year":"2000","journal-title":"Stroke"},{"key":"R15-15-20210203","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00062752-200209000-00004","article-title":"Clinical application of the PFA-100","volume":"9","author":"Favaloro","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"R16-15-20210203","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-0032-1313613","article-title":"Preliminary data from a field trial of the PFA-100\u00ae system","volume":"21","author":"Mammen","year":"1995","journal-title":"Semin Thromb Hemost"},{"key":"R17-15-20210203","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-2999(02)02956-4","article-title":"Effect of a single dose aspirin on platelets in humans with multiple risk factors for coronary artery disease","volume":"462","author":"Malinin","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"R18-15-20210203","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0735-1097(02)03014-0","article-title":"A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease","volume":"41","author":"Gum","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R19-15-20210203","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1161\/01.CIR.103.21.2572","article-title":"Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention: results of the GOLD (AU-Assessing Ultegra) multicenter study","volume":"103","author":"Steinhubl","year":"2001","journal-title":"Circulation"},{"key":"R20-15-20210203","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1161\/01.CIR.0000013777.21160.07","article-title":"Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events","volume":"105","author":"Eikelboom","year":"2002","journal-title":"Circulation"},{"key":"R21-15-20210203","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1055\/s-0038-1657677","article-title":"Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty","volume":"78","author":"Mueller","year":"1997","journal-title":"Thromb Haemost"},{"key":"R22-15-20210203","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0049-3848(93)90164-J","article-title":"Two-year follow-up of aspirin responder and aspirin non responder a pilot-study including 180 post-stroke patients","volume":"71","author":"Grotemeyer","year":"1993","journal-title":"Thromb Res"},{"key":"R23-15-20210203","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00415-003-0954-y","article-title":"Aspirin non-responder status in patients with recurrent cerebral ischemic attacks","volume":"250","author":"Grundmann","year":"2003","journal-title":"J Neurol"},{"key":"R24-15-20210203","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0049-3848(02)00405-X","article-title":"Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease","volume":"108","author":"Andersen","year":"2002","journal-title":"Thromb Res"},{"key":"R25-15-20210203","first-page":"1385","article-title":"Results of the BRAT study \u2013 a pilot study investigating the possible significance of ASA nonresponsiveness on the benefits and risks of ASA on thrombosis in patients undergoing coronary artery bypass surgery","volume":"16","author":"Buchanan","year":"2000","journal-title":"Can J Cardiol"}],"container-title":["Blood Coagulation & Fibrinolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MBC.0b013e328040c115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:19:16Z","timestamp":1786033156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001721-200703000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/mbc.0b013e328040c115","relation":{},"ISSN":["0957-5235"],"issn-type":[{"value":"0957-5235","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}