{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:15:06Z","timestamp":1786119306140,"version":"build-2736575974"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1097\/mbc.0b013e3282f3f9ec","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T13:52:31Z","timestamp":1236261151000},"page":"375-382","source":"Crossref","is-referenced-by-count":64,"title":["High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study"],"prefix":"10.1097","volume":"19","author":[{"given":"Stephan","family":"Koenig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Gerstner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Teich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Longin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Erik","family":"Dempfle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20210203","first-page":"435","article-title":"Proprietes pharmacodynamiques de l'acide n-dipropylacetique","volume":"18","author":"Meunier","year":"1963","journal-title":"Therapie"},{"key":"R2-7-20210203","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/088307380201700110","article-title":"Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid","volume":"17","author":"Serdaroglu","year":"2002","journal-title":"J Child Neurol"},{"key":"R3-7-20210203","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-2002-34499","article-title":"Pro- and anticoagulatory factors under sodium valproate-therapy in children","volume":"33","author":"Banerjea","year":"2002","journal-title":"Neuropediatrics"},{"key":"R4-7-20210203","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1046\/j.1365-2516.1999.00340.x","article-title":"Acquired von Willebrand syndrome\u2013 report of 10 cases and review of the literature","volume":"5","author":"Nitu-Whalley","year":"1999","journal-title":"Haemophilia"},{"key":"R5-7-20210203","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/S0140-6736(80)92543-X","article-title":"Acute liver failure associated with sodium valproate","volume":"2","author":"Ware","year":"1980","journal-title":"Lancet"},{"key":"R6-7-20210203","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1378\/chest.117.2.613","article-title":"Fatal pulmonary hemorrhage during high-dose valproate monotherapy","volume":"117","author":"Sleiman","year":"2000","journal-title":"Chest"},{"key":"R7-7-20210203","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0140-6736(91)92902-E","article-title":"Valproic-acid-induced pancytopenia and Coombs test positivity","volume":"337","author":"Kaya","year":"1991","journal-title":"Lancet"},{"key":"R8-7-20210203","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/BF01957735","article-title":"Fatal pancytopenia during high-dose valproate monotherapy [letter]","volume":"151","author":"Rajantie","year":"1992","journal-title":"Eur J Pediatr"},{"key":"R9-7-20210203","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0887-8994(96)00124-5","article-title":"Perioperative blood loss: the effect of valproate","volume":"15","author":"Winter","year":"1996","journal-title":"Pediatr Neurol"},{"key":"R10-7-20210203","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1056\/NEJM198003203021204","article-title":"Drug therapy: valproic acid","volume":"302","author":"Koch-Weser","year":"1980","journal-title":"N Engl J Med"},{"key":"R11-7-20210203","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/j.1528-1157.1984.tb05636.x","article-title":"Adverse effects of valproate","volume":"25","author":"Schmidt","year":"1984","journal-title":"Epilepsia"},{"key":"R12-7-20210203","first-page":"137","article-title":"Delayed-onset dose-related valproate-induced thrombocytopenia","volume":"40","author":"Sherbany","year":"1990","journal-title":"Neurology"},{"key":"R13-7-20210203","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1528-1157.1992.tb02303.x","article-title":"Valproate therapy induces von Willebrand disease type I","volume":"33","author":"Kreuz","year":"1992","journal-title":"Epilepsia"},{"key":"R14-7-20210203","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/bmj.280.6208.186-b","article-title":"Letter: sodium valproate and platelet counts","volume":"280","author":"Eastham","year":"1980","journal-title":"Br Med J"},{"key":"R15-7-20210203","first-page":"210","article-title":"Gerinnungsst\u00f6rung unter Valproins\u00e4ure","author":"von Czettritz","year":"1992"},{"key":"R16-7-20210203","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1528-1157.1999.tb02073.x","article-title":"Influence of valproate monotherapy on platelet activation and hematologic values","volume":"40","author":"Zeller","year":"1999","journal-title":"Epilepsia"},{"key":"R17-7-20210203","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0387-7604(95)00139-5","article-title":"Hematologic manifestations and impaired liver synthetic function during valproate monotherapy","volume":"18","author":"Hauser","year":"1996","journal-title":"Brain Dev"},{"key":"R18-7-20210203","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1528-1157.1982.tb05085.x","article-title":"Sodium valproate: monotherapy and polytherapy","volume":"23","author":"Covanis","year":"1982","journal-title":"Epilepsia"},{"key":"R19-7-20210203","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/adc.57.9.681","article-title":"Valproic acid and immune thrombocytopenia","volume":"57","author":"Barr","year":"1982","journal-title":"Arch Dis Child"},{"key":"R20-7-20210203","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1528-1157.1982.tb05085.x","article-title":"Sodium valproate: monotherapy and polytherapy","volume":"23","author":"Covanis","year":"1982","journal-title":"Epilepsia"},{"key":"R21-7-20210203","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ana.410050414","article-title":"Thrombocytopenia associated with sodium valproate treatment","volume":"5","author":"Neophytides","year":"1979","journal-title":"Ann Neurol"},{"key":"R22-7-20210203","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/ana.410080213","article-title":"Sodium valproate and bone marrow suppression","volume":"8","author":"Smith","year":"1980","journal-title":"Ann Neurol"},{"key":"R23-7-20210203","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/088307389400900318","article-title":"Thrombocytopenia secondary to high valproate levels in children with epilepsy","volume":"9","author":"Delgado","year":"1994","journal-title":"J Child Neurol"},{"key":"R24-7-20210203","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00043426-199021000-00016","article-title":"Severe hematologic toxicity of valproic acid. A report of four patients","volume":"12","author":"Ganick","year":"1990","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"R25-7-20210203","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1212\/WNL.44.8.1418","article-title":"Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration","volume":"44","author":"Gidal","year":"1994","journal-title":"Neurology"},{"key":"R26-7-20210203","first-page":"15","article-title":"Valproic acid and thrombocytopenia: cross-sectional study","volume":"7","author":"Ko","year":"2001","journal-title":"Hong Kong Med J"},{"key":"R27-7-20210203","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1528-1167.2006.00587.x","article-title":"Valproate-associated coagulopathies are frequent and variable in children","volume":"47","author":"Gerstner","year":"2006","journal-title":"Epilepsia"},{"key":"R28-7-20210203","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1528-1157.1981.tb04094.x","article-title":"Sodium valproate, platelet dysfunction and bleeding","volume":"22","author":"Loiseau","year":"1981","journal-title":"Epilepsia"},{"key":"R29-7-20210203","first-page":"1098","article-title":"Thrombozytenwerte bei Erwachsenen unter Behandlung mit DPA (Ergenyl)","volume":"28","author":"Krause","year":"1977","journal-title":"Med Welt"},{"key":"R30-7-20210203","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0049-3848(96)00019-9","article-title":"The platelet aggregation in a child receiving valproic acid","volume":"81","author":"Tanindi","year":"1996","journal-title":"Thromb Res"},{"key":"R31-7-20210203","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0022-3476(05)81105-9","article-title":"Valproic acid-induced cytopenias: evidence for a dose related suppression of hematopoiesis","volume":"117","author":"Watts","year":"1990","journal-title":"J Pediatr"},{"key":"R32-7-20210203","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/adc.71.2.153","article-title":"Bone marrow suppression induced by high dose valproic acid","volume":"71","author":"Kishi","year":"1994","journal-title":"Arch Dis Child"},{"key":"R33-7-20210203","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0022-3476(97)70292-0","article-title":"Thrombocytic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid","volume":"130","author":"Stahl","year":"1997","journal-title":"J Pediatr"},{"key":"R34-7-20210203","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1136\/bmj.2.6153.1683","article-title":"IgM platelet auto-antibody due to sodium valproate","volume":"2","author":"Sandler","year":"1978","journal-title":"BMJ"},{"key":"R35-7-20210203","first-page":"1397","article-title":"Side effects of sodium valproate (sodium di-N-propylacetate) on malonyldialdehyde-production and other platelet function tests","volume":"30","author":"von Hoss","year":"1978","journal-title":"Minerva Pediatr"},{"key":"R36-7-20210203","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2141.1977.tb00584.x","article-title":"Defective platelet lipid peroxidation in myeloproliferative disorders: a possible defect of prostaglandin synthesis","volume":"35","author":"Keenan","year":"1977","journal-title":"J Haematol"},{"key":"R37-7-20210203","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF03008150","article-title":"Intraoperative defect in haemostasis in a child receiving valproic acid","volume":"38","author":"Tetzlaff","year":"1991","journal-title":"Can J Anaesth"},{"key":"R38-7-20210203","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1034\/j.1600-0404.2003.00149.x","article-title":"Valproate induces reversible factor XIII deficiency with risk of perioperative bleeding","volume":"108","author":"Pohlmann-Eden","year":"2003","journal-title":"Acta Neurol Scand"},{"key":"R39-7-20210203","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.0013-9580.2004.28302.x","article-title":"Factor XIII deficiency with valproate treatment","volume":"45","author":"Teich","year":"2004","journal-title":"Epilepsia"},{"key":"R40-7-20210203","first-page":"828","article-title":"Koagulopathien","author":"Heene","year":"1993"},{"key":"R41-7-20210203","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3171\/jns.1997.87.2.0252","article-title":"Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment","volume":"87","author":"Anderson","year":"1997","journal-title":"J Neurosurg"},{"key":"R42-7-20210203","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1177\/106002809402801123","article-title":"Neonatal fibrinogen depletion caused by sodium valproate","volume":"28","author":"Bavoux","year":"1994","journal-title":"Ann Pharmacother"},{"key":"R43-7-20210203","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0140-6736(78)91308-9","article-title":"Fibrinogen depletion with sodium valproate","volume":"17","author":"Dale","year":"1978","journal-title":"Lancet"},{"key":"R44-7-20210203","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1528-1157.1999.tb02054.x","article-title":"Lupus anticoagulant induced by the combinationof valproate and lamotrigine","volume":"40","author":"Echinaz-Laguna","year":"1999","journal-title":"Epilepsia"},{"key":"R45-7-20210203","first-page":"448","article-title":"Beeinflussung der H\u00e4mostase durch Dipropylessigs\u00e4ure","volume":"124","author":"Gadner","year":"1976","journal-title":"Monatsschr Kinderheilkd"},{"key":"R46-7-20210203","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1528-1157.1997.tb01227.x","article-title":"Letter to editor","volume":"38","author":"Gil-Fernandez","year":"1997","journal-title":"Epilepsia"},{"key":"R47-7-20210203","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0140-6736(87)91098-1","article-title":"Neonatal afibrinogenaemia due to sodium valproate","volume":"2","author":"Majer","year":"1987","journal-title":"Lancet"},{"key":"R48-7-20210203","first-page":"603","article-title":"Alteration de l'hemostase lors des traitements au dipropylacetate de sodium","volume":"34","author":"Monnet","year":"1979","journal-title":"Pediatrie"},{"key":"R49-7-20210203","first-page":"242","article-title":"Fibrinogen and valproic acid","volume":"22","author":"Ojemann","year":"1981","journal-title":"Epilepsia"},{"key":"R50-7-20210203","first-page":"50","article-title":"Three cases of hypofibrinogenaemia induced by chemotherapy with a combination of synthetic ACTH and valproic acid","volume":"26","author":"Tokuda","year":"1994","journal-title":"No To Hattatsu"},{"key":"R51-7-20210203","article-title":"Gerinnungsanalysen\u2013 6. Auflage","author":"Barthels","year":"1998"},{"key":"R52-7-20210203","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1528-1157.1996.tb00519.x","article-title":"Preoperative valproate administration does not increase blood loss during temporal lobectomy","volume":"37","author":"Ward","year":"1996","journal-title":"Epilepsia"}],"container-title":["Blood Coagulation & Fibrinolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001721-200807000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:56:28Z","timestamp":1786038988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001721-200807000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/mbc.0b013e3282f3f9ec","relation":{},"ISSN":["0957-5235"],"issn-type":[{"value":"0957-5235","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}