{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:51:13Z","timestamp":1791078673579,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1097\/mbc.0b013e32832f5d7a","type":"journal-article","created":{"date-parts":[[2009,9,29]],"date-time":"2009-09-29T03:14:48Z","timestamp":1254194088000},"page":"503-510","source":"Crossref","is-referenced-by-count":28,"title":["Prevalence of factor V Leiden and prothrombin G20210A mutation in a large French population selected for nonthrombotic history: geographical and age distribution"],"prefix":"10.1097","volume":"20","author":[{"given":"Elisabeth","family":"Mazoyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Ripoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Gueguen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Tiret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Collet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bal dit Sollier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Roussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Drouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210203","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","article-title":"World distribution of factor V Leiden","volume":"346","author":"Rees","year":"1995","journal-title":"Lancet"},{"key":"R2-4-20210203","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1365-2141.1996.d01-1954.x","article-title":"The population genetics of factor V Leiden (Arg506Gln)","volume":"95","author":"Rees","year":"1996","journal-title":"Br J Haematol"},{"key":"R3-4-20210203","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-0038-1655963","article-title":"Prevalence of Factor V Leiden mutation in non-European population","volume":"77","author":"Pepe","year":"1997","journal-title":"Thromb Haemost"},{"key":"R4-4-20210203","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1006\/bcmd.2001.0388","article-title":"Population genetics of factor V Leiden in Europe","volume":"27","author":"Lucotte","year":"2001","journal-title":"Blood Cells Mol Dis"},{"key":"R5-4-20210203","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2257.2006.00757.x","article-title":"Prevalence of factor V Leiden and prothrombin G20210 mutations in Chinese patients with deep venous thrombosis and pulmonary embolism","volume":"28","author":"Jun","year":"2006","journal-title":"Clin Lab Haematol"},{"key":"R6-4-20210203","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/1096-8652(200010)65:2<119::AID-AJH5>3.0.CO;2-8","article-title":"Prevalence of the G1691A mutation in the factor V gene (factor V Leiden) and the G20210A prothrombin gene mutation in the Thai population.","volume":"65","author":"Angchaisuksiri","year":"2000","journal-title":"Am J Hematol"},{"key":"R7-4-20210203","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/1096-8652(200009)65:1<45::AID-AJH8>3.0.CO;2-V","article-title":"The prevalence of factor V R506Q mutation Leiden among apparently healthy Lebanese","volume":"65","author":"Irani-Hakime","year":"2000","journal-title":"Am J Hematol"},{"key":"R8-4-20210203","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/ajh.20582","article-title":"Distinct association of Factor V-Leiden and prothrombin G20210A mutations with deep venous thrombosis in Tunisian and Lebanon","volume":"81","author":"Bouaziz-Borgi","year":"2006","journal-title":"Am J Hematol"},{"key":"R9-4-20210203","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11239-005-3550-4","article-title":"Varied prevalence of Factor V G1691A (Leiden) and Prothrombin G20210 single nucleotide polymorphism among Arabs","volume":"20","author":"Almawi","year":"2005","journal-title":"J Thromb Thrombol"},{"key":"R10-4-20210203","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1055\/s-0037-1615049","article-title":"Geographic distribution of the 20210G to A prothrombin variant","volume":"79","author":"Rosendaal","year":"1998","journal-title":"Thromb Haemost"},{"key":"R11-4-20210203","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/clinchem\/47.10.1879","article-title":"Age-dependent prevalence of vascular disease-associated polymorphisms among 2689 volunteer blood donors","volume":"47","author":"Hessner","year":"2001","journal-title":"Clin Chem"},{"key":"R12-4-20210203","first-page":"607","article-title":"The risk of mortality and of Factor V Leiden in a population-based cohort","volume":"80","author":"Heijmans","year":"1998","journal-title":"Thromb Haemost"},{"key":"R13-4-20210203","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1538-7836.2004.01071.x","article-title":"ABO blood group genotypes and the risk of venous thrombosis effect of factor V Leiden","volume":"3","author":"Morelli","year":"2005","journal-title":"J Thromb Haemost"},{"key":"R14-4-20210203","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2141.2006.06353.x","article-title":"ABO blood group but not haemostasis genetic polymorphisms significantly influence thrombotic risk: a study of 180 homozygotes for factor V Leiden mutation.","volume":"135","year":"2006","journal-title":"Br J Haematol"},{"key":"R15-4-20210203","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1073\/pnas.90.3.1004","article-title":"Familial thrombophilia due to a previous unrecognised mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C","volume":"90","author":"Dahlback","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R16-4-20210203","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/369064a0","article-title":"Mutation in blood coagulation factor V associated with resistance to activated protein C","volume":"369","author":"Bertina","year":"1994","journal-title":"Nature"},{"key":"R17-4-20210203","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","article-title":"A common genetic variation in the 3\u2032-unrelated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis","volume":"88","author":"Poort","year":"1996","journal-title":"Blood"},{"key":"R18-4-20210203","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ng578","article-title":"Increased efficiency of mRNA 3\u2032end formation: a new genetic mechanism contribution to hereditary thrombophilia","volume":"28","author":"Gehring","year":"2001","journal-title":"Nat Genet"},{"key":"R19-4-20210203","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1160\/TH05-08-0582","article-title":"Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels","volume":"95","author":"Brugge","year":"2006","journal-title":"Thromb Haemost"},{"key":"R20-4-20210203","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1055\/s-0038-1657661","article-title":"Multiplex PCR-mediated site-directed mutagenesis for one-step determination of factor V Leiden and G20210A transition of the prothrombin gene","volume":"78","author":"Ripoll","year":"1997","journal-title":"Thromb Haemost"},{"key":"R21-4-20210203","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extraction DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acid Res"},{"key":"R22-4-20210203","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00000441-199107000-00004","article-title":"Measurement of platelet mediated force development during plasma clot formation","volume":"302","author":"Carr","year":"1991","journal-title":"Am J Med Sci"},{"key":"R23-4-20210203","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00000441-199401000-00003","article-title":"Quantitative assessment of platelet function and clot structure in patients with severe coronary artery disease","volume":"307","author":"Greilich","year":"1994","journal-title":"Am J Med Sci"},{"key":"R24-4-20210203","first-page":"237","article-title":"Frequency of Factor V Leiden (Arg506Gln) in France","volume":"99","author":"Lucotte","year":"1997","journal-title":"Br J Haematol"},{"key":"R25-4-20210203","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00277-003-0663-8","article-title":"Assessment of the 20210 G to A prothrombin variant in a sample of patients from the French Basque country with various thrombophilic conditions","volume":"82","author":"Bauduer","year":"2003","journal-title":"Ann Hematol"},{"key":"R26-4-20210203","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1538-7933.2004.0584i.x","article-title":"The prevalence of factor V G1691A but not of prothrombin G20210A and methylenetetrahydrofolate reductase C677T is remarkably low in French Basques","volume":"2","author":"Bauduer","year":"2004","journal-title":"J Thromb Haemost"},{"key":"R27-4-20210203","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00001721-200207000-00013","article-title":"Comparative evaluation of five different methods for the measurement of plasma factor II levels in carriers of the 20210A prothrombin variant","volume":"13","author":"Delahouse","year":"2002","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R28-4-20210203","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0049-3848(00)00281-4","article-title":"Prothrombin activity and concentration in healthy subjects with and without the prothrombin G20210A mutation","volume":"99","author":"Von Ahsen","year":"2000","journal-title":"Thromb Res"},{"key":"R29-4-20210203","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1055\/s-0037-1615965","article-title":"Polymorphisms in the prothrombin gene and their association with plasma prothrombin levels","volume":"85","author":"Ceelie","year":"2001","journal-title":"Thromb Haemost"},{"key":"R30-4-20210203","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/01.ATV.18.3.458","article-title":"Plasma lipoproteins support prothrombinase and other procoagulant enzymatic complexes","volume":"18","author":"Moyer","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R31-4-20210203","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1161\/01.ATV.14.11.1737","article-title":"Correlation of vitamin K dependent clotting factors with cholesterol and triglycerides in healthy young adults","volume":"14","author":"Hoffman","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"R32-4-20210203","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.ATV.12.3.267","article-title":"Correlation of factor VII activity and antigen with cholesterol and triglycerides in healthy young adults","volume":"12","author":"Hoffman","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"R33-4-20210203","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1182\/blood-2002-08-2527","article-title":"Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk","volume":"101","author":"Wolberg","year":"2003","journal-title":"Blood"},{"key":"R34-4-20210203","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1182\/blood-2005-12-5158","article-title":"Prothrombin 20210G>A is an ancestral prothromotic mutation that occurred in whites approximately 24000 years ago","volume":"107","author":"Zivelin","year":"2006","journal-title":"Blood"},{"key":"R35-4-20210203","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S0140-6736(96)90181-6","article-title":"Mutant factor V (Arg506Gln) in healthy centenarians","volume":"347","author":"Mari","year":"1996","journal-title":"Lancet"}],"container-title":["Blood Coagulation &amp; Fibrinolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MBC.0b013e32832f5d7a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:00:38Z","timestamp":1786039238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001721-200910000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/mbc.0b013e32832f5d7a","relation":{},"ISSN":["0957-5235"],"issn-type":[{"value":"0957-5235","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}