{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:44Z","timestamp":1786119464995,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/mbc.0b013e32833678be","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T01:06:34Z","timestamp":1264640794000},"page":"158-163","source":"Crossref","is-referenced-by-count":9,"title":["Effect of caffeic acid phenethyl ester on the hemostatic alterations associated with toxic-induced acute liver failure"],"prefix":"10.1097","volume":"21","author":[{"given":"Aida A","family":"Korish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210203","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/0002-9343(94)90183-X","article-title":"Acute liver failure","volume":"96","author":"Lee","year":"1994","journal-title":"Am J Med"},{"key":"R2-10-20210203","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11894-008-0023-x","article-title":"Epidemiology of acute liver failure","volume":"9","author":"Khashab","year":"2007","journal-title":"Curr Gastroentrol Rep"},{"key":"R3-10-20210203","first-page":"111","article-title":"Antihepato-cytotoxic serum treatment results in acute liver failure","volume":"130","author":"Topuria","year":"2006","journal-title":"Georgian Med News"},{"key":"R4-10-20210203","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1089-3261(03)00026-6","article-title":"Fulminant liver disease","volume":"7","author":"Schiodt","year":"2003","journal-title":"Clin Liver Dis"},{"key":"R5-10-20210203","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1478-3231.2006.01327.x","article-title":"Role of neutrophils in acute inflammatory liver injury","volume":"26","author":"Jaeschke","year":"2006","journal-title":"Liver Int"},{"key":"R6-10-20210203","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00024382-199501000-00010","article-title":"Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia","volume":"3","author":"Liu","year":"1995","journal-title":"Shock"},{"key":"R7-10-20210203","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-2002-23205","article-title":"Coagulation disorders in liver disease","volume":"22","author":"Amitrano","year":"2002","journal-title":"Semin Liver Dis"},{"issue":"Suppl 1","key":"R8-10-20210203","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/00001721-200004001-00014","article-title":"Coagulation problems in liver disease","volume":"11","author":"Rapaport","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R9-10-20210203","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJM199908193410807","article-title":"Disseminated intravascular coagulation","volume":"341","author":"Plevi","year":"1999","journal-title":"N Engl J Med"},{"key":"R10-10-20210203","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cld.2008.09.011","article-title":"Coagulation disorders and bleeding in liver disease: future directions","volume":"13","author":"Caldwell","year":"2009","journal-title":"Clin Liver Dis"},{"key":"R11-10-20210203","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cld.2008.10.001","article-title":"Coagulopathy of acute liver failure","volume":"13","author":"Munoz","year":"2009","journal-title":"Clin Liver Dis"},{"issue":"Suppl 1","key":"R12-10-20210203","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0367-326X(02)00185-5","article-title":"Propolis, an old remedy used in modern medicine","volume":"73","author":"Castaldo","year":"2002","journal-title":"Fitoterpia"},{"key":"R13-10-20210203","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0308-8146(02)00231-5","article-title":"Preparations and antioxidant properties of water extract of propolis","volume":"80","author":"Nagai","year":"2003","journal-title":"Food Chem"},{"key":"R14-10-20210203","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000026427","article-title":"Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation","volume":"7","author":"Orban","year":"2000","journal-title":"Neuroimmunomodulation"},{"key":"R15-10-20210203","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/01.ATV.0000148404.24271.fc","article-title":"Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice","volume":"25","author":"Hishikawa","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"Suppl 1","key":"R16-10-20210203","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0367-326X(02)00187-9","article-title":"Antioxidant activity of propolis: role of caffeic acid phenethylester and galangin","volume":"73","author":"Russo","year":"2002","journal-title":"Fitoterapia"},{"key":"R17-10-20210203","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1021\/jf034729d","article-title":"Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis","volume":"51","author":"Liao","year":"2003","journal-title":"J Agric Food Chem"},{"key":"R18-10-20210203","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1073\/pnas.90.6.2399","article-title":"Inhibitors of human immunodeficiency virus integrase","volume":"90","author":"Fesen","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R19-10-20210203","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF01941717","article-title":"Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis","volume":"4","author":"Grunberger","year":"1988","journal-title":"Experientia"},{"key":"R20-10-20210203","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0022-3468(99)90103-3","article-title":"Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats","volume":"34","author":"Koltuksuz","year":"1999","journal-title":"J Pediatr Surg"},{"key":"R21-10-20210203","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/cbf.1232","article-title":"Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat","volume":"24","author":"Iraz","year":"2006","journal-title":"Cell Biochem Funct"},{"key":"R22-10-20210203","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2008.03.009","article-title":"Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice","volume":"248","author":"Lee","year":"2008","journal-title":"Toxicology"},{"key":"R23-10-20210203","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neulet.2005.04.023","article-title":"The flavonoid caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity.","volume":"383","author":"Noelker","year":"2005","journal-title":"Neurosci Lett"},{"key":"R24-10-20210203","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/SHK.0b013e318197118e","article-title":"Sialic acid reduces acute endotoxemia-induced liver dysfunction in the rat.","volume":"32","author":"Ho","year":"2009","journal-title":"Shock"},{"key":"R25-10-20210203","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbamcr.2004.08.013","article-title":"Expression of catalase and glutathione peroxidase in renal insufficiency","volume":"1743","author":"Sindhu","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"R26-10-20210203","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0003-2697(88)90554-4","article-title":"A spectrophotometeric method for determination of catalase activity in small tissue samples","volume":"174","author":"Johansson","year":"1988","journal-title":"Anal Biochem"},{"key":"R28-10-20210203","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"R29-10-20210203","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12028-008-9087-6","article-title":"The coagulopathy of acute liver failure and implications for intracranial pressure monitoring","volume":"9","author":"Munoz","year":"2008","journal-title":"Neurocrit Care"},{"key":"R30-10-20210203","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/hep.510290222","article-title":"Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress","volume":"9","author":"Jaeschke","year":"1999","journal-title":"Hepatology"},{"key":"R31-10-20210203","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0300-483X(03)00157-4","article-title":"Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients","volume":"189","author":"Basu","year":"2003","journal-title":"Toxicology"},{"key":"R32-10-20210203","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1182\/blood.V55.6.1020.1020","article-title":"An oxygen-dependent mechanism of neutrophil-mediated cytotoxicity","volume":"55","author":"Weiss","year":"1980","journal-title":"Blood"},{"key":"R33-10-20210203","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s10620-008-0405-9","article-title":"Protective effects of caffeic acid phenethyl ester on intestinal ischemia\u2013reperfusion injury","volume":"54","author":"Yildiz","year":"2009","journal-title":"Dig Dis Sci"},{"key":"R34-10-20210203","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1016\/j.biocel.2008.05.005","article-title":"Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38\/ERK and NF-kappaB pathways","volume":"40","author":"Yildiz","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"R35-10-20210203","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.ijporl.2006.05.018","article-title":"Role of caffeic acid phenethyl ester, an active component of propolis, against NaOH-induced esophageal burns in rats","volume":"70","author":"Ocakci","year":"2006","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"R36-10-20210203","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1073\/pnas.93.17.9090","article-title":"Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B","volume":"93","author":"Natarajan","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R37-10-20210203","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/MCG.0b013e31804c707c","article-title":"Predictive role of nuclear factor-kappaB activity in gastric cancer: a promising adjuvant approach with caffeic acid phenethyl ester","volume":"41","author":"Wu","year":"2007","journal-title":"J Clin Gastroenterol"},{"key":"R38-10-20210203","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bjps.2006.01.030","article-title":"Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia\u2013reperfusion injury in rat skin flaps","volume":"60","author":"Aydogan","year":"2007","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"R39-10-20210203","first-page":"BR187","article-title":"The effect of caffeic acid phenethyl ester on short-term acute myocardial ischemia.","volume":"12","author":"Ince","year":"2006","journal-title":"Med Sci Monit"},{"key":"R40-10-20210203","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pupt.2005.03.006","article-title":"Effect of caffeic acid phenethyl ester on lipopolysaccharide-induced lung injury in rats","volume":"19","author":"Koksel","year":"2006","journal-title":"Pulm Pharmacol Ther"},{"key":"R41-10-20210203","first-page":"95","article-title":"Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases","volume":"36","author":"Rahman","year":"2003","journal-title":"J Biochem Mol Biol"},{"key":"R42-10-20210203","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.4049\/jimmunol.169.9.5294","article-title":"A small molecule inhibitor of redox-regulated NF kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model","volume":"169","author":"Henderson","year":"2002","journal-title":"J Immunol"},{"key":"R43-10-20210203","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-\u03baB and I\u03baB proteins: new discoveries and insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Ann Rev Immunol"},{"key":"R44-10-20210203","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S1357-2725(96)00159-8","article-title":"Nuclear factor-kappa B","volume":"29","author":"Barnes","year":"1997","journal-title":"Int J Biochem Cell Biol"},{"key":"R45-10-20210203","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.vph.2007.04.008","article-title":"Caffeic acid phenethyl ester (CAPE) protects rat skeletal muscle against ischemia\u2013reperfusion-induced oxidative stress","volume":"47","author":"Ozyurt","year":"2007","journal-title":"Vascul Pharmacol"},{"key":"R46-10-20210203","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.lfs.2008.01.014","article-title":"Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma","volume":"82","author":"Jung","year":"2008","journal-title":"Life Sci"},{"key":"R47-10-20210203","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1191\/0748233705th216oa","article-title":"The activities of liver adenosine deaminase, xanthine oxidase, catalase, superoxide dismutase enzymes and the levels of malondialdehyde and nitric oxide after cisplatin toxicity in rats: protective effect of caffeic acid phenethyl ester","volume":"21","author":"Yilmaz","year":"2005","journal-title":"Toxicol Ind Health"}],"container-title":["Blood Coagulation & Fibrinolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MBC.0b013e32833678be","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:18:12Z","timestamp":1786040292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001721-201003000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/mbc.0b013e32833678be","relation":{},"ISSN":["0957-5235"],"issn-type":[{"value":"0957-5235","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}