{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:15:48Z","timestamp":1786119348515,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1097\/mbc.0b013e3283444ddb","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T04:44:12Z","timestamp":1300337052000},"page":"337-339","source":"Crossref","is-referenced-by-count":10,"title":["Severe prekallikrein deficiency due to a homozygous Trp499Stop nonsense mutation"],"prefix":"10.1097","volume":"22","author":[{"given":"Takafumi","family":"Nakao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Yamane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Katagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasukatsu","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Samori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Iwao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210203","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1182\/blood.V26.5.521.521","article-title":"Evidence for a new plasma thromboplastin factor. I: Case report, coagulation studies and physicochemical properties","volume":"26","author":"Hathaway","year":"1965","journal-title":"Blood"},{"key":"R2-16-20210203","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1056\/NEJM198110153051602","article-title":"Heterogeneity of human prekallikrein deficiency (Fletcher trait): evidence that five of 18 cases are positive for cross-reacting material","volume":"305","author":"Saito","year":"1981","journal-title":"N Engl J Med"},{"key":"R3-16-20210203","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00007611-199104000-00027","article-title":"Stroke in a young adult with Fletcher trait","volume":"84","author":"Hess","year":"1991","journal-title":"South Med J"},{"key":"R4-16-20210203","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3143\/geriatrics.46.348","article-title":"An elderly case of congenital prekallikrein deficiency","volume":"46","author":"Nagaya","year":"2009","journal-title":"Nippon Ronen Igakkai Zasshi"},{"key":"R5-16-20210203","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MAJ.0b013e3181b270bb","article-title":"A case of prekallikrein deficiency resulting in severe recurrent mucosal hemorrhage","volume":"338","author":"Dasanu","year":"2009","journal-title":"Am J Med Sci"},{"key":"R6-16-20210203","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/geno.2000.6330","article-title":"Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease","volume":"69","author":"Yu","year":"2000","journal-title":"Genomics"},{"key":"R7-16-20210203","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1046\/j.1538-7836.2003.00154.x","article-title":"Prekallikrein (PK) Tokushima: PK deficiency caused by a Gly401\u2014>Glu mutation","volume":"1","author":"Shigekiyo","year":"2003","journal-title":"J Thromb Haemost"},{"key":"R8-16-20210203","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1160\/TH03-05-0275","article-title":"Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr)","volume":"90","author":"Lombardi","year":"2003","journal-title":"Thromb Haemost"},{"key":"R9-16-20210203","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2141.2004.05180.x","article-title":"Severe prekallikrein deficiency associated with homozygosity for an Arg94Stop nonsense mutation","volume":"127","author":"Wynne Jones","year":"2004","journal-title":"Br J Haematol"},{"key":"R10-16-20210203","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0609.2007.00871.x","article-title":"A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region","volume":"79","author":"Katsuda","year":"2007","journal-title":"Eur J Haematol"},{"key":"R11-16-20210203","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1055\/s-0037-1617022","article-title":"Severe prekallikrein deficiency due to a compound heterozygosis in the KLKB1-gene","volume":"29","author":"Maak","year":"2009","journal-title":"Hamostaseologie"},{"key":"R12-16-20210203","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ajh.21654","article-title":"A large family from Argentina with prekallikrein deficiency due to a compound heterozygosis (T insertion in intron 7 and Asp558Glu in exon 15): prekallikrein Cordoba","volume":"85","author":"Girolami","year":"2010","journal-title":"Am J Hematol"},{"key":"R13-16-20210203","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/MBC.0b013e328010bcde","article-title":"Severe prekallikrein deficiencies due to homozygous C529Y mutations","volume":"18","author":"Francois","year":"2007","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R14-16-20210203","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00281268","article-title":"HLA typing in a new family with Fletcher factor deficiency","volume":"60","author":"Raffoux","year":"1982","journal-title":"Hum Genet"},{"key":"R15-16-20210203","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0028-1086135","article-title":"Management of idiopathic thrombocytopenic purpura in the adult","volume":"3","author":"Lacey","year":"1977","journal-title":"Semin Thromb Hemost"}],"container-title":["Blood Coagulation & Fibrinolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001721-201106000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:01:49Z","timestamp":1786039309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001721-201106000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/mbc.0b013e3283444ddb","relation":{},"ISSN":["0957-5235"],"issn-type":[{"value":"0957-5235","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}