{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:13:18Z","timestamp":1793643198716,"version":"4.5.1"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1097\/mbc.0b013e3283614210","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T08:56:00Z","timestamp":1379667360000},"page":"683-690","source":"Crossref","is-referenced-by-count":22,"title":["Factors that influence the bleeding phenotype in severe hemophilic patients"],"prefix":"10.1097","volume":"24","author":[{"given":"Pablo","family":"Rendo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Shafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Korth-Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupa","family":"Sivamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Korin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-2-20210203","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0140-6736(03)13405-8","article-title":"Haemophilias A and B.","volume":"361","author":"Bolton-Maggs","year":"2003","journal-title":"Lancet"},{"key":"R4-2-20210203","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1365-2516.2011.02506.x","article-title":"Comparing bleed frequency and factor concentrate use between haemophilia A and B patients.","volume":"17","author":"Nagel","year":"2011","journal-title":"Haemophilia"},{"key":"R5-2-20210203","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1182\/blood-2009-01-195313","article-title":"Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the 2 coagulation disorders.","volume":"114","author":"Tagariello","year":"2009","journal-title":"Blood"},{"key":"R6-2-20210203","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1056\/NEJMoa067659","article-title":"Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.","volume":"357","author":"Manco-Johnson","year":"2007","journal-title":"N Engl J Med"},{"key":"R7-2-20210203","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1365-2141.2001.02580.x","article-title":"Long-term outcome of individualized prophylactic treatment of children with severe haemophilia.","volume":"112","author":"van den Berg","year":"2001","journal-title":"Br J Haematol"},{"key":"R8-2-20210203","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1538-7836.2011.04214.x","article-title":"A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Study).","volume":"9","author":"Gringeri","year":"2011","journal-title":"J Thromb Haemost"},{"key":"R9-2-20210203","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1055\/s-0037-1615621","article-title":"Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis.","volume":"85","author":"White","year":"2001","journal-title":"Thromb Haemost"},{"key":"R10-2-20210203","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2516.2011.02539.x","article-title":"Clinical severity of haemophilia A: does the classification of the 1950s still stand H","volume":"17","author":"Den Uijl","year":"2011","journal-title":"aemophilia"},{"key":"R11-2-20210203","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0031-1300953","article-title":"Role of molecular genetics in hemophilia: from diagnosis to therapy.","volume":"38","author":"Jayandharan","year":"2012","journal-title":"Semin Thromb Hemost"},{"key":"R12-2-20210203","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2516.2004.01036.x","article-title":"A 6-year follow-up of dosing, coagulation factor levels and bleedings in relation to joint status in the prophylactic treatment of haemophilia.","volume":"10","author":"Ahnstrom","year":"2004","journal-title":"Haemophilia"},{"key":"R13-2-20210203","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1182\/blood.V84.7.2197.2197","article-title":"Analysis of intron 22 inversions of the factor VIII gene in severe hemophilia A: implications for genetic counseling.","volume":"84","author":"Jenkins","year":"1994","journal-title":"Blood"},{"key":"R14-2-20210203","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.1073\/pnas.88.19.8307","article-title":"Molecular characterization of mild-to-moderate hemophilia A: detection of the mutation in 25 of 29 patients by denaturing gradient gel electrophoresis.","volume":"88","author":"Higuchi","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R15-2-20210203","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1365-2516.2009.02080.x","article-title":"Polymorphism in factor VII gene modifies phenotype of severe haemophilia.","volume":"15","author":"Jayandharan","year":"2009","journal-title":"Haemophilia"},{"key":"R16-2-20210203","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1160\/TH04-02-0112","article-title":"Do prothrombotic factors influence clinical phenotype of severe haemophilia A review of the literature.","volume":"92","author":"van Dijk","year":"2004","journal-title":"Thromb Haemost"},{"key":"R18-2-20210203","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1046\/j.1365-2141.2001.02813.x","article-title":"A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state.","volume":"113","author":"Dykes","year":"2001","journal-title":"Br J Haematol"},{"key":"R19-2-20210203","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0038-1653730","article-title":"Prevalence of protein C deficiency in the healthy population.","volume":"73","author":"Tait","year":"1995","journal-title":"Thromb Haemost"},{"key":"R20-2-20210203","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ajh.2830450409","article-title":"Prevalence of antithrombin deficiency in healthy blood donors: a cross-sectional study.","volume":"45","author":"Wells","year":"1994","journal-title":"Am J Hematol"},{"key":"R21-2-20210203","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/369064a0","article-title":"Mutation in blood coagulation factor V associated with resistance to activated protein C.","volume":"369","author":"Bertina","year":"1994","journal-title":"Nature"},{"key":"R22-2-20210203","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(94)92939-4","article-title":"Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V.","volume":"343","author":"Voorberg","year":"1994","journal-title":"Lancet"},{"key":"R23-2-20210203","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","article-title":"World distribution of factor V Leiden.","volume":"346","author":"Rees","year":"1995","journal-title":"Lancet"},{"key":"R24-2-20210203","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(05)80081-9","article-title":"Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study.","volume":"342","author":"Koster","year":"1993","journal-title":"Lancet"},{"key":"R25-2-20210203","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0140-6736(94)92497-X","article-title":"Activated protein C resistance caused by Arg506Gln mutation in factor Va.","volume":"343","author":"Greengard","year":"1994","journal-title":"Lancet"},{"key":"R26-2-20210203","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1182\/blood.V82.7.1989.1989","article-title":"Anticoagulant protein C pathway defective in majority of thrombophilic patients.","volume":"82","author":"Griffin","year":"1993","journal-title":"Blood"},{"key":"R27-2-20210203","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJM199402243300801","article-title":"Resistance to activated protein C as a basis for venous thrombosis.","volume":"330","author":"Svensson","year":"1994","journal-title":"N Engl J Med"},{"key":"R29-2-20210203","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/beha.1999.0036","article-title":"Hyperhomocysteinaemia.","volume":"12","author":"Perry","year":"1999","journal-title":"Baillieres Best Pract Res Clin Haematol"},{"key":"R30-2-20210203","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1182\/blood-2003-06-1794","article-title":"Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia.","volume":"103","author":"Krajinovic","year":"2004","journal-title":"Blood"},{"key":"R31-2-20210203","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1309\/6A8UURH9NU2YNFBP","article-title":"Reduced clinical severity in a mutationally well characterized cohort of severe hemophilia with associated thrombophilia.","volume":"130","author":"Shetty","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"R32-2-20210203","first-page":"9","article-title":"Milder clinical presentation of haemophilia A with severe deficiency of factor VIII as measured by one-stage assay.","volume":"7","author":"Ghosh","year":"2001","journal-title":"Haemophilia"},{"key":"R33-2-20210203","first-page":"71","article-title":"Does the MTHFR 677T allele alter the clinical phenotype in severe haemophilia A Thromb R","volume":"109","author":"Ahmed","year":"2003","journal-title":"es"},{"key":"R34-2-20210203","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-0037-1613824","article-title":"Effect of the factor V Leiden mutation on the clinical expression of severe hemophilia A.","volume":"83","author":"Lee","year":"2000","journal-title":"Thromb Haemost"},{"key":"R35-2-20210203","first-page":"36","article-title":"Haemophilia and thrombophilia.","volume":"23","author":"Nowak-Gottl","year":"2003","journal-title":"What do we learn about combined inheritance of both genetic variations Hamostaseologie"},{"key":"R36-2-20210203","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3324\/haematol.11161","article-title":"Effects of the factor V G1691A mutation and the factor II G20210A variant on the clinical expression of severe hemophilia A in children--results of a multicenter studys.","volume":"92","author":"Kurnik","year":"2007","journal-title":"Haematologica"},{"key":"R37-2-20210203","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1055\/s-0037-1615679","article-title":"Symptomatic onset of severe hemophilia A in childhood is dependent on the presence of prothrombotic risk factors.","volume":"85","author":"Escuriola Ettingshausen","year":"2001","journal-title":"Thromb Haemost"},{"key":"R38-2-20210203","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2516.2010.02358.x","article-title":"Association between haemophilia and inherited thrombophilia: a single centre survey.","volume":"17","author":"Di Perna","year":"2011","journal-title":"Haemophilia"},{"key":"R39-2-20210203","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1538-7836.2008.03001.x","article-title":"Validation of a composite score for clinical severity of hemophilia.","volume":"6","author":"Schulman","year":"2008","journal-title":"J Thromb Haemost"},{"key":"R41-2-20210203","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1046\/j.1365-2516.2002.00686.x","article-title":"Paradoxical hyperfibrinolysis is associated with a more intensely haemorrhagic phenotype in severe congenital haemophilia.","volume":"8","author":"Grunewald","year":"2002","journal-title":"Haemophilia"},{"key":"R42-2-20210203","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3324\/haematol.2011.042663","article-title":"Up-regulation of platelet activation in hemophilia A.","volume":"96","author":"van Bladel","year":"2011","journal-title":"Haematologica"},{"key":"R43-2-20210203","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3324\/haematol.2012.065235","article-title":"Activation state of platelet in experimental severe hemophilia A.","volume":"97","author":"Teyssandier","year":"2012","journal-title":"Haematologica"},{"issue":"Suppl 5","key":"R44-2-20210203","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2516.2010.02309_2.x","article-title":"Update on pathogenesis of the bleeding joint: an interplay between inflammatory and degenerative pathways.","volume":"16","author":"Van Meegeren","year":"2010","journal-title":"Haemophilia"},{"key":"R45-2-20210203","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1365-2141.2008.07386.x","article-title":"Understanding haemophilic arthropathy: an exploration of current open issues.","volume":"143","author":"Jansen","year":"2008","journal-title":"Br J Haematol"},{"key":"R46-2-20210203","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1182\/blood-2004-11-4342","article-title":"HFE mutations in the pathobiology of hemophilic arthropathy.","volume":"105","author":"Cruz","year":"2005","journal-title":"Blood"},{"key":"R47-2-20210203","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/art.30094","article-title":"Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load.","volume":"63","author":"Carroll","year":"2011","journal-title":"Arthritis Rheum"},{"key":"R48-2-20210203","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1002\/art.23970","article-title":"HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis.","volume":"58","author":"Wagener","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R49-2-20210203","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1302\/0301-620X.80B3.0800540","article-title":"Iron deposits and catabolic properties of synovial tissue from patients with haemophilia.","volume":"80","author":"Roosendaal","year":"1998","journal-title":"J Bone Joint Surg Br"},{"key":"R50-2-20210203","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1365-2516.2008.01973.x","article-title":"IL-1 beta, IL-6, KC and MCP-1 are elevated in synovial fluid from haemophilic mice with experimentally induced haemarthrosis.","volume":"15","author":"Ovlisen","year":"2009","journal-title":"Haemophilia"},{"key":"R51-2-20210203","first-page":"1311","article-title":"Tissue cytokine patterns distinguish variants of rheumatoid synovitis.","volume":"151","author":"Klimiuk","year":"1997","journal-title":"Am J Pathol"},{"key":"R52-2-20210203","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1399-0039.1997.tb02715.x","article-title":"Polymorphism at the TNF loci in rheumatoid arthritis.","volume":"49","author":"Vinasco","year":"1997","journal-title":"Tissue Antigens"},{"key":"R53-2-20210203","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/art.11160","article-title":"Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.","volume":"48","author":"Lard","year":"2003","journal-title":"Arthritis Rheum"},{"key":"R54-2-20210203","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1365-2141.2008.07278.x","article-title":"Interleukin-10 protects against blood-induced joint damage.","volume":"142","author":"Jansen","year":"2008","journal-title":"Br J Haematol"},{"key":"R55-2-20210203","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1182\/blood-2003-12-4231","article-title":"Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene.","volume":"104","author":"Hakobyan","year":"2004","journal-title":"Blood"},{"key":"R56-2-20210203","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1182\/blood-2002-02-0390","article-title":"c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide.","volume":"100","author":"Wen","year":"2002","journal-title":"Blood"},{"key":"R57-2-20210203","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1182\/blood-2010-05-284653","article-title":"Neoangiogenesis contributes to the development of hemophilic synovitis.","volume":"117","author":"Acharya","year":"2011","journal-title":"Blood"},{"key":"R58-2-20210203","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1365-2249.2003.02101.x","article-title":"High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies.","volume":"132","author":"Drouart","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"R59-2-20210203","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0024-3205(01)01264-4","article-title":"Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis correlation with disease activity.","volume":"69","author":"Sone","year":"2001","journal-title":"Life Sci"},{"key":"R60-2-20210203","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/bmj.3.5777.771","article-title":"Periodic haemorrhages in haemophilia A.","volume":"3","author":"Benbassat","year":"1971","journal-title":"BMJ"},{"key":"R61-2-20210203","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1182\/blood-2006-05-020495","article-title":"Cutaneous wound healing is impaired in hemophilia B.","volume":"108","author":"Hoffman","year":"2006","journal-title":"Blood"},{"key":"R62-2-20210203","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/01.ATV.20.5.1374","article-title":"Vascular endothelial growth factor production by fibroblasts in response to factor VIIa binding to tissue factor involves thrombin and factor Xa.","volume":"20","author":"Ollivier","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R63-2-20210203","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.freeradbiomed.2005.11.016","article-title":"Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes.","volume":"40","author":"Jazwa","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"R64-2-20210203","first-page":"659","article-title":"Meteorologic effects on hemorrhagic diathesis in hemophilia. 2. Weather effects on hemophilia with special reference to the atmospheric temperature-humidity complex.","volume":"45","author":"Linde","year":"1990","journal-title":"Z Gesamte Inn Med"},{"key":"R65-2-20210203","first-page":"631","article-title":"Recommendations for a medical-meteorologic prognosis for hemophilia.","volume":"117","author":"Linde","year":"1990","journal-title":"Folia Haematol Int Mag Klin Morphol Blutforsch"},{"key":"R66-2-20210203","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2141.1973.tb01680.x","article-title":"A three-year study of adolescent boys suffering from haemophilia and allied disorders.","volume":"24","author":"Rainsford","year":"1973","journal-title":"Br J Haematol"},{"key":"R67-2-20210203","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1182\/blood.V104.11.3094.3094","article-title":"Variability in bleeding pattern of severe hemophilia abstract.","volume":"104","author":"van Dijk","year":"2004","journal-title":"Blood"},{"key":"R69-2-20210203","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1365-2516.2002.00575.x","article-title":"The effect of resistance training on the frequency of bleeding in haemophilia patients: a pilot study.","volume":"8","author":"Tiktinsky","year":"2002","journal-title":"Haemophilia"},{"key":"R70-2-20210203","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1111\/j.1365-2516.2011.02521.x","article-title":"Does weight reduction in haemophilia lead to a decrease in joint bleeds H","volume":"18","author":"Majumdar","year":"2012","journal-title":"aemophilia"},{"key":"R71-2-20210203","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2516.2010.02400.x","article-title":"The longitudinal effect of body adiposity on joint mobility in young males with Haemophilia A.","volume":"17","author":"Soucie","year":"2011","journal-title":"Haemophilia"},{"key":"R72-2-20210203","first-page":"89","article-title":"The use of hypnosis with hemophilia.","volume":"10","author":"LaBaw","year":"1992","journal-title":"Psychiatr Med"}],"container-title":["Blood Coagulation &amp; Fibrinolysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MBC.0b013e3283614210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T02:31:33Z","timestamp":1620959493000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00001721-201310000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/mbc.0b013e3283614210","relation":{},"ISSN":["0957-5235"],"issn-type":[{"value":"0957-5235","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}