{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:41:48Z","timestamp":1777866108384,"version":"3.51.4"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biodegradable polymer drug-eluting stents (BP-DES) are currently used in percutaneous coronary intervention (PCI). Polymer-free drug-eluting stents (PF-DES) have the potential to mitigate any risk associated with BP-DES; however, the relative efficacy and safety of these interventions remain to be fully elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search of PubMed, Embase, and Cochrane Central was performed from inception to January 2025 to identify randomized controlled trials and observational studies comparing PF-DES with BP-DES in patients undergoing PCI. Heterogeneity was assessed using the\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      \u00b2 statistic. A two-sided\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value less than 0.05 was considered statistically significant. Prespecified subgroup analyses were conducted based on follow-up duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of seven randomized controlled trials (RCTs) and four observational studies comprising 11 954 patients were included, of whom 5947 (49.7%) received PF-DES. In the pooled analysis, no statistically significant differences were observed between PF-DES and BP-DES in terms of cardiac death [risk ratio: 1.12, 95% confidence interval (CI): 0.96\u20131.31,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.15], target lesion failure (risk ratio: 1.09, 95% CI: 0.81\u20131.46,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.58), stent thrombosis (risk ratio: 0.90, 95% CI: 0.58\u20131.41,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.64), target lesion revascularization (risk ratio: 1.28, 95% CI: 0.81\u20132.02,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.28), or target vessel revascularization (risk ratio: 1.05, 95% CI: 0.70\u20131.58,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.79). Likewise, no significant subgroup effect was observed regarding longer-term follow-up outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta-analysis found comparable safety and efficacy outcomes between PF-DES and BP-DES in patients undergoing PCI; however, further RCTs are needed to evaluate long-term outcomes and newer-generation stent models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mca.0000000000001602","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T15:00:09Z","timestamp":1765983609000},"page":"316-326","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative efficacy of polymer-free versus biodegradable-polymer drug-eluting stents in percutaneous coronary intervention: an updated systematic review and meta-analysis"],"prefix":"10.1097","volume":"37","author":[{"given":"Sebastian","family":"Jaramillo","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Biom\u00e9dicas, Universidad Austral, Pilar, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Pinilla","sequence":"additional","affiliation":[{"name":"CES University, Medellin, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Stabile","sequence":"additional","affiliation":[{"name":"University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius Bittar","family":"de Pontes","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio das Faculdades Associadas de Ensino, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Cheikh","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helios Klinikum Erfurt, Universit\u00e4rer Campus der Health and Medical University, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Webster","family":"Donaldy","sequence":"additional","affiliation":[{"name":"NYC Health + Hospitals, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilton","family":"Gomes","sequence":"additional","affiliation":[{"name":"INC Hospital, Curitiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"R1-20260430","doi-asserted-by":"crossref","first-page":"f6625","DOI":"10.1136\/bmj.f6625","article-title":"Bare metal stents, durable polymer drug eluting stents, and biodegradable polymer drug eluting stents for coronary artery disease: mixed treatment comparison 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