{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:58:58Z","timestamp":1785160738064,"version":"3.55.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Supersaturated oxygen (SSO\n                      <jats:sub>2<\/jats:sub>\n                      ) is a novel adjunctive treatment aims to reduce reperfusion injury after primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). We conducted this study to evaluate the efficacy and safety of SSO\n                      <jats:sub>2<\/jats:sub>\n                      therapy in patients with STEMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we systematically searched Cochrane Central, Embase, PubMed, Scopus, and Web of Science for studies comparing SSO\n                      <jats:sub>2<\/jats:sub>\n                      therapy post-PCI with PCI alone in adults with STEMI. Primary efficacy outcomes were infarct size and all-cause death. A random-effects model was used for analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six unique studies that enrolled 1591 patients were included [518 (32.5%) of whom received SSO\n                      <jats:sub>2<\/jats:sub>\n                      ]. SSO\n                      <jats:sub>2<\/jats:sub>\n                      therapy was associated with a reduction in infarct size compared with the control group [mean difference = \u22124.7% of left ventricular mass, 95% confidence interval (CI): \u22128.3 to \u22121.1%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.01], with the greatest benefit observed in patients reperfused within 6 h of symptom onset (mean difference = \u22126.0% of left ventricular mass, 95% CI: \u22128.9 to \u22123.0%). SSO\n                      <jats:sub>2<\/jats:sub>\n                      therapy was also associated with reduced left ventricular end-systolic volume (mean difference = \u221219.9\u2005ml, 95% CI: \u221233.7 to \u22126.2). The between-group difference in all-cause mortality was NS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u20050.58); however, an association between SSO\n                      <jats:sub>2<\/jats:sub>\n                      use and reduced all-cause death was present in the two studies with long-term (1-year) follow-up (risk ratio\u2005=\u20050.10, 95% CI: 0.01\u20130.77). No safety concerns were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      SSO\n                      <jats:sub>2<\/jats:sub>\n                      administration in patients with STEMI after primary PCI was safe and was associated with reduced infarct size, particularly when administered within 6 h of symptom onset. This myocardial salvage was associated with improvement in left ventricular function Further randomized trials are needed to definitively establish the impact of SSO\n                      <jats:sub>2<\/jats:sub>\n                      on mortality and heart failure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mca.0000000000001663","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:00:13Z","timestamp":1785157213000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Intracoronary supersaturated oxygen therapy after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: a systematic review and meta-analysis"],"prefix":"10.1097","author":[{"given":"Alaa Abdrabou","family":"Abouelmagd","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Qena University, Qena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Nazmy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Kafr-Elsheikh University, Kafr-Elsheikh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen Negmeldin","family":"Yassin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Kasr Al-Ainy, Cairo University, Cairo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman A.","family":"Elareef","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Alexandria University, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Esam","family":"Shalaan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Kasr Al-Ainy, Cairo University, Cairo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Health System\/Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Michael","family":"Gibson","sequence":"additional","affiliation":[{"name":"Baim Institute for Clinical Research, Harvard Medical School, Harvard University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute of Primary Care and Health Sciences, Keele University, Stoke-on-Trent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"CORRIB Research Centre for Advanced Imaging and Core Laboratory"},{"name":"Department of Cardiology, Saolta Group, Galway University Hospital Health Service Executive, University of Galway, Galway, Ireland and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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