{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:13:12Z","timestamp":1786119192317,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1097\/mca.0b013e3282f08ece","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T17:22:30Z","timestamp":1236100950000},"page":"539-544","source":"Crossref","is-referenced-by-count":20,"title":["Plasma asymmetric dimethylarginine and L-arginine levels in patients with cardiac syndrome X"],"prefix":"10.1097","volume":"18","author":[{"given":"Kaan","family":"Okyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atiye","family":"Cengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asife","family":"Sahinarslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Tavil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedat","family":"Turkoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulser","family":"Biberoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alev","family":"Hasanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210204","first-page":"III16","article-title":"The clinical spectrum of coronary artery disease and its surgical and medical management, 1974\u20131979. The Coronary Artery Surgery Study","volume":"66","author":"Kennedy","year":"1982","journal-title":"Circulation"},{"key":"R2-6-20210204","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0002-9343(73)90060-0","article-title":"The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience","volume":"54","author":"Kemp","year":"1973","journal-title":"Am J Med"},{"key":"R3-6-20210204","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0025-6196(11)63226-6","article-title":"Pathophysiology, diagnosis, and current management strategies for chest pain in patients with normal findings on angiography","volume":"76","author":"Al Suwaidi","year":"2001","journal-title":"Mayo Clin Proc"},{"key":"R4-6-20210204","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.amjmed.2005.07.009","article-title":"Cardiac syndrome X and endothelial dysfunction: new concepts in prognosis and treatment","volume":"119","author":"Hurst","year":"2006","journal-title":"Am J Med"},{"key":"R5-6-20210204","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1056\/NEJM199007053230106","article-title":"Regulatory functions of the vascular endothelium","volume":"323","author":"Vane","year":"1990","journal-title":"N Engl J Med"},{"key":"R6-6-20210204","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM199201233260406","article-title":"The pathogenesis of coronary artery disease","volume":"326","author":"Fuster","year":"1992","journal-title":"N Engl J Med"},{"key":"R7-6-20210204","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1161\/01.CIR.85.6.2284","article-title":"Nitric oxide inhibitor of platelet adhesion under flow conditions","volume":"85","author":"De Graaf","year":"1992","journal-title":"Circulation"},{"key":"R8-6-20210204","first-page":"364","article-title":"Nitric oxide and cardiovascular system","volume":"6","author":"Cengel","year":"2006","journal-title":"Anadolu Kardiyol Derg"},{"key":"R9-6-20210204","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/327524a0","article-title":"Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor","volume":"327","author":"Palmer","year":"1987","journal-title":"Nature"},{"issue":"12","key":"R10-6-20210204","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1097\/00005344-199204002-00018","article-title":"Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis","volume":"20","author":"Vallance","year":"1992","journal-title":"J Cardiovasc Pharmacol"},{"key":"R11-6-20210204","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1161\/01.CIR.98.18.1842","article-title":"Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia","volume":"98","author":"Boger","year":"1998","journal-title":"Circulation"},{"key":"R12-6-20210204","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.RES.87.2.99","article-title":"LDL cholesterol upregulates synthesis of asymmetric dimethylarginine in human endothelial cells. Involvement of S-adenosylmethionine-dependent methyltransferases","volume":"87","author":"Boger","year":"2000","journal-title":"Circ Res"},{"key":"R13-6-20210204","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/01.ATV.20.9.2032","article-title":"Does ADMA cause endothelial dysfunction?","volume":"20","author":"Cooke","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R14-6-20210204","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.amjhyper.2004.05.005","article-title":"Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients","volume":"17","author":"Takiuchi","year":"2004","journal-title":"Am J Hypertens"},{"key":"R15-6-20210204","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jacc.2005.04.040","article-title":"Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension","volume":"46","author":"Perticone","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"R16-6-20210204","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.CIR.93.5.879","article-title":"TIMI frame count. A quantitative method of assessing coronary artery flow","volume":"93","author":"Gibson","year":"1996","journal-title":"Circulation"},{"key":"R17-6-20210204","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.97.23.2302","article-title":"Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade. Zwolle Myocardial Infarction Study Group","volume":"97","author":"Van't Hof","year":"1998","journal-title":"Circulation"},{"key":"R18-6-20210204","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.amjcard.2005.05.024","article-title":"Angiographic evaluation of myocardial perfusion in patients with syndrome X","volume":"96","author":"Atmaca","year":"2005","journal-title":"Am J Cardiol"},{"key":"R19-6-20210204","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/MCA.0b013e32801104fc","article-title":"Coronary blood flow in patients with cardiac syndrome X","volume":"18","author":"Sen","year":"2007","journal-title":"Coron Artery Dis"},{"key":"R20-6-20210204","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0378-4347(96)00531-2","article-title":"Determination of NG, NG-dimethylarginine in human plasma by high-performance liquid chromatography","volume":"692","author":"Chen","year":"1997","journal-title":"J Chromatography B"},{"key":"R21-6-20210204","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00005344-199904000-00020","article-title":"Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension","volume":"33","author":"Surdacki","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"R22-6-20210204","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/jama.287.11.1420","article-title":"Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor","volume":"287","author":"St\u00fchlinger","year":"2002","journal-title":"JAMA"},{"key":"R23-6-20210204","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0008-6363(02)00617-X","article-title":"ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocys(e)inemia: effects of L-arginine and B vitamins","volume":"57","author":"Sydow","year":"2003","journal-title":"Cardiovasc Res"},{"key":"R24-6-20210204","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.atherosclerosis.2005.05.002","article-title":"Relations between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary disease","volume":"184","author":"Wang","year":"2006","journal-title":"Atherosclerosis"},{"key":"R25-6-20210204","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.niox.2006.10.003","article-title":"Aortic stenosis is associated with elevated plasma levels of asymmetric dimethylarginine (ADMA)","volume":"16","author":"Ngo","year":"2007","journal-title":"Nitric Oxide"},{"key":"R26-6-20210204","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.mca.0000236282.81985.e2","article-title":"Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography","volume":"17","author":"Sahinarslan","year":"2006","journal-title":"Coron Artery Dis"},{"key":"R27-6-20210204","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ahj.2006.06.005","article-title":"Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study","volume":"152","author":"Schulze","year":"2006","journal-title":"Am Heart J"},{"key":"R28-6-20210204","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.CIR.94.2.130","article-title":"Effects of L-arginine supplementation on endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary arteriograms","volume":"94","author":"Egashira","year":"1996","journal-title":"Circulation"},{"key":"R29-6-20210204","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0002-9149(02)02664-4","article-title":"Long-term angiotensin-converting enzyme inhibition reduces plasma asymmetric dimethylarginine and improves endothelial nitric oxide bioavailability and coronary microvascular function in patients with syndrome X","volume":"90","author":"Chen","year":"2002","journal-title":"Am J Cardiol"},{"key":"R30-6-20210204","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/01.CIR.0000046489.24563.79","article-title":"Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms. Correlation with asymmetric dimethylarginine levels","volume":"107","author":"Piatti","year":"2003","journal-title":"Circulation"},{"key":"R31-6-20210204","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0735-1097(02)02174-5","article-title":"Plasma asymmetric dimethylarginine and hyperemic myocardial blood flow in young subjects with borderline hypertension or familial hypercholesterolemia","volume":"40","author":"Paiva","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"R32-6-20210204","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1161\/01.CIR.95.8.2068","article-title":"Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease","volume":"95","author":"B\u00f6ger","year":"1997","journal-title":"Circulation"},{"key":"R33-6-20210204","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.amjcard.2005.12.069","article-title":"Microvascular function, metabolic syndrome, and novel risk factor status in women with cardiac syndrome X","volume":"97","author":"Jadhav","year":"2006","journal-title":"Am J Cardiol"},{"key":"R34-6-20210204","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/hrt.2003.020594","article-title":"Angina pectoris and normal coronary arteries: cardiac syndrome X","volume":"90","author":"Crea","year":"2004","journal-title":"Heart"},{"key":"R35-6-20210204","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0002-9149(99)00532-9","article-title":"Effects of atrial pacing on arterial and coronary sinus endothelin-1 levels in syndrome X","volume":"84","author":"Lanza","year":"1999","journal-title":"Am J Cardiol"}],"container-title":["Coronary Artery Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MCA.0b013e3282f08ece","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:42:25Z","timestamp":1786038145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00019501-200711000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/mca.0b013e3282f08ece","relation":{},"ISSN":["0954-6928"],"issn-type":[{"value":"0954-6928","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}