{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:08:12Z","timestamp":1786118892336,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1097\/mca.0b013e32830936e5","type":"journal-article","created":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T03:09:19Z","timestamp":1223262559000},"page":"429-434","source":"Crossref","is-referenced-by-count":14,"title":["Impact of endothelin-1 Lys198Asn polymorphism on coronary artery disease and endorgan damage in hypertensives"],"prefix":"10.1097","volume":"19","author":[{"given":"Aron Frederik","family":"Popov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egbert Godehard","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Hinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Dieter","family":"Schmitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Seipelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Johann","family":"Koziolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Rosenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich Albert","family":"Schoendube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard Anton","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20210204","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"R2-1-20210204","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1073\/pnas.86.8.2863","article-title":"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes","volume":"86","author":"Inoue","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R3-1-20210204","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/01.CIR.89.3.1320","article-title":"The endothelin system. A new target for therapeutic intervention","volume":"89","author":"Yanagisawa","year":"1994","journal-title":"Circulation"},{"issue":"(4 Pt 1)","key":"R4-1-20210204","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/ajh\/4.4.303","article-title":"Plasma endothelin in human essential hypertension","volume":"4","author":"Schiffrin","year":"1991","journal-title":"Am J Hypertens"},{"issue":"6","key":"R5-1-20210204","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00005344-198906146-00014","article-title":"Endothelium-derived vasoactive substances: potential role in hypertension, atherosclerosis, and vascular occlusion","volume":"14","author":"Luscher","year":"1989","journal-title":"J Cardiovasc Pharmacol"},{"key":"R6-1-20210204","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1291\/hypres.27.367","article-title":"Evaluation of the Lys198Asn and -134delA genetic polymorphisms of the endothelin-1 gene","volume":"27","author":"Tanaka","year":"2004","journal-title":"Hypertens Res"},{"issue":"(6 Pt 1)","key":"R7-1-20210204","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/01.HYP.21.6.747","article-title":"Is endothelin involved in the pathogenesis of hypertension?","volume":"21","author":"Vanhoutte","year":"1993","journal-title":"Hypertension"},{"key":"R8-1-20210204","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0002-9343(90)90527-K","article-title":"Plasma immunoreactive endothelin in essential hypertension","volume":"88","author":"Kohno","year":"1990","journal-title":"Am J Med"},{"key":"R9-1-20210204","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1291\/hypres.24.663","article-title":"Associations of plasma endothelin concentration with carotid atherosclerosis and asymptomatic cerebrovascular lesions in patients with essential hypertension","volume":"24","author":"Minami","year":"2001","journal-title":"Hypertens Res"},{"key":"R10-1-20210204","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-2999(01)00905-0","article-title":"Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy","volume":"417","author":"Cullen","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"R11-1-20210204","first-page":"334","article-title":"The accumulation of extracellular matrix in the kidney: consequences on cellular function","volume":"18","author":"Ruiz-Torres","year":"2005","journal-title":"J Nephrol"},{"key":"R12-1-20210204","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ki.1991.38","article-title":"Urinary excretion of endothelin-1 in normal subjects and patients with renal disease","volume":"39","author":"Ohta","year":"1991","journal-title":"Kidney Int"},{"key":"R13-1-20210204","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1172\/JCI119297","article-title":"Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension","volume":"99","author":"Hocher","year":"1997","journal-title":"J Clin Invest"},{"key":"R14-1-20210204","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1097\/01.ASN.0000031803.55613.86","article-title":"Genetic dissection of increased urinary albumin excretion in the munich wistar fr\u00f6mter rat","volume":"13","author":"Schulz","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R15-1-20210204","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/01.HYP.33.5.1169","article-title":"The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people","volume":"33","author":"Tiret","year":"1999","journal-title":"Hypertension"},{"key":"R16-1-20210204","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1161\/hy1101.095333","article-title":"Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: the Ohasama Study","volume":"38","author":"Asai","year":"2001","journal-title":"Hypertension"},{"key":"R17-1-20210204","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.HYP.0000043680.75107.CF","article-title":"Association of endothelin-1 gene variant with hypertension","volume":"41","author":"Jin","year":"2003","journal-title":"Hypertension"},{"key":"R18-1-20210204","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/hy0202.103442","article-title":"Preproendothelin-1 gene polymorphism is related to a change in vascular reactivity in the human mammary artery in vitro","volume":"39","author":"Iglarz","year":"2002","journal-title":"Hypertension"},{"key":"R19-1-20210204","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1097\/00004872-200110000-00011","article-title":"Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy","volume":"19","author":"Barden","year":"2001","journal-title":"J Hypertens"},{"key":"R20-1-20210204","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1161\/01.HYP.0000075790.33892.AE","article-title":"Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Seventh report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7): resetting the hypertension sails","volume":"41","author":"Lenfant","year":"2003","journal-title":"Hypertension"},{"key":"R21-1-20210204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00041552-200101000-00001","article-title":"Research on renal endothelin in proteinuric nephropathies dictates novel strategies to prevent progression","volume":"10","author":"Benigni","year":"2001","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R22-1-20210204","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000168707","article-title":"Immunohistochemical distribution of endothelin in biopsies of pediatric nephrotic syndrome","volume":"14","author":"Murer","year":"1994","journal-title":"Am J Nephrol"},{"key":"R23-1-20210204","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1097\/01.ASN.0000089827.03201.8E","article-title":"Role of the endothelin-1 gene locus for renal impairment in the general nondiabetic population","volume":"14","author":"Pinto-Sietsma","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"R24-1-20210204","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1161\/01.CIR.89.4.1573","article-title":"Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction","volume":"89","author":"Omland","year":"1994","journal-title":"Circulation"},{"key":"R25-1-20210204","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/384353a0","article-title":"Inhibition of myocardial endothelin pathway improves long-term survival in heart failure","volume":"384","author":"Sakai","year":"1996","journal-title":"Nature"},{"key":"R26-1-20210204","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1161\/01.CIR.99.16.2118","article-title":"Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure","volume":"99","author":"Zolk","year":"1999","journal-title":"Circulation"},{"key":"R27-1-20210204","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0008-6363(00)00081-X","article-title":"Endothelin receptor antagonism in patients with chronic heart failure","volume":"47","author":"Love","year":"2000","journal-title":"Cardiovasc Res"},{"key":"R28-1-20210204","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000092374","article-title":"ET-1 Lys198Asn and ET(A) receptor H323H polymorphisms in heart failure. A case-control study","volume":"105","author":"Colombo","year":"2006","journal-title":"Cardiology"},{"key":"R29-1-20210204","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJM199110033251404","article-title":"Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis","volume":"325","author":"Lerman","year":"1991","journal-title":"N Engl J Med"},{"key":"R30-1-20210204","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/01.CIR.91.4.941","article-title":"Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina","volume":"91","author":"Zeiher","year":"1995","journal-title":"Circulation"},{"key":"R31-1-20210204","doi-asserted-by":"crossref","first-page":"14367","DOI":"10.1073\/pnas.95.24.14367","article-title":"Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice","volume":"95","author":"Barton","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R32-1-20210204","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/01.ATV.0000012804.63152.60","article-title":"Combined endothelin receptor blockade evokes enhanced vasodilatation in patients with atherosclerosis","volume":"22","author":"B\u00f6hm","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R33-1-20210204","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/01.fpc.0000230118.26581.40","article-title":"Risk of coronary artery disease as influenced by variants of the human endothelin and endothelin-converting enzyme genes","volume":"17","author":"B\u00fchler","year":"2007","journal-title":"Pharmacogenet Genomics"}],"container-title":["Coronary Artery Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MCA.0b013e32830936e5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:02:26Z","timestamp":1786035746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00019501-200811000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/mca.0b013e32830936e5","relation":{},"ISSN":["0954-6928"],"issn-type":[{"value":"0954-6928","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}