{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:35:38Z","timestamp":1793104538510,"version":"4.5.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe prenatal evaluation and postnatal outcome of monochorionic diamniotic twins with discordant anomalies and genetic findings after intracytoplasmic sperm injection and double-embryo transfer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 36-year-old gravida 3 para 0 woman conceived after transfer of two blastocysts. Ultrasound identified monochorionic diamniotic twins and a liver-containing omphalocele in fetus B. Both sacs underwent separate amniocentesis. Testing included karyotyping, chromosome microarray, Beckwith\u2013Wiedemann syndrome analysis, trio whole-exome sequencing, short tandem repeat analysis, postnatal peripheral blood fluorescence in situ hybridization, and placental histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fetus A had mosaic 45,X[9]\/46,XY[91]; fetus B had a 46,XY karyotype. Other prenatal genetic tests were unremarkable. Discordance at 11 of 21 short tandem repeat loci supported dizygosity. Following prelabor rupture of membranes at 34 + 5 weeks, two male infants were delivered by cesarean section. Twin A had hypospadias and bilateral cryptorchidism; twin B had giant omphalocele requiring surgical repair. Postnatal fluorescence in situ hybridization detected no sex-chromosome mosaicism. Placental histopathology confirmed monochorionicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Monochorionicity does not exclude dizygosity after assisted reproduction. Separate sampling of both sacs may inform discordant cases, and prenatal\u2013postnatal discrepancies in 45,X\/46,XY mosaicism warrant cautious longitudinal interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/mcd.0000000000000575","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:00:09Z","timestamp":1786100409000},"page":"153-158","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Monochorionic dizygotic twins with discordant genetic findings and congenital malformations"],"prefix":"10.1097","volume":"35","author":[{"given":"Caiqun","family":"Luo","sequence":"first","affiliation":[{"name":"Maternal-Fetal Medicine Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wu","sequence":"additional","affiliation":[{"name":"Maternal-Fetal Medicine 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mosaicism.","volume":"62","author":"Xia","year":"2024","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"R11-20261027","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1017\/thg.2021.20","article-title":"Monochorionic dizygotic twins conceived spontaneously showed chimerism in karyotype and blood group type.","volume":"24","author":"Yoshida","year":"2023","journal-title":"Twin Res Hum Genet"}],"container-title":["Clinical 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