{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:18:22Z","timestamp":1782922702590,"version":"3.54.5"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims:<\/jats:title>\n            <jats:p>Albumin modifications and deranged functions are well documented in serum of severe alcoholic hepatitis (SAH). We investigated whether urinary albumin (u-Alb) can serve as surrogate marker of circulatory albumin phenotype, functionality, and could predict outcome in SAH patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patients and Methods:<\/jats:title>\n            <jats:p>Baseline serum and urine samples from 100 SAH, 20 alcoholic cirrhosis, and 20 healthy controls were subjected to u-Alb, ischemia modified albumin (IMA), IMA to albumin ratio (IMAr), advanced oxidation protein products, advanced glycation end-products, albumin-binding capacity determination. In addition, SAH urinary samples were also analyzed at day 4 and day 7 to predict nonresponse to corticosteroid therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Urine and serum levels of IMA, advanced oxidation protein products and advanced glycation end-products were higher (<jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05) in SAH versus alcoholic cirrhosis and healthy controls. IMAr was low in urine but high in serum of SAH (<jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05). Albumin-binding capacity was lower (<jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05) in both urinary and serum albumin of SAH. Urinary and serum albumin parameters showed direct correlation, whereas IMAr showed inverse correlation (cc&gt;0.2, <jats:italic toggle=\"yes\">P<\/jats:italic>&lt;0.05). Baseline u-Alb level was significantly higher in SAH, and was correlated directly with corticosteroid treatment outcome and 12-month mortality in SAH. Baseline u-Alb showed an area under the receivers operating curve analysis of 0.7 and a hazard ratio of 1.23 for prediction of 12-month mortality in SAH. Baseline u-Alb level &gt;9.0\u2009mg\/dL was associated with reduced 12-month survival in SAH (log rank &lt;0.01).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>u-Alb modifications are reflective of serum albumin modifications. Further baseline u-Alb levels could be exploited to predict steroid response and mortality in SAH patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/mcg.0000000000000990","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T13:37:40Z","timestamp":1516887460000},"page":"e243-e252","source":"Crossref","is-referenced-by-count":11,"title":["Modification Patterns of Urinary Albumin Correlates With Serum Albumin and Outcome in Severe Alcoholic Hepatitis"],"prefix":"10.1097","volume":"53","author":[{"given":"Sukanta","family":"Das","sequence":"first","affiliation":[{"name":"Molecular and Cellular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shabir","family":"Hussain","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaswinder S.","family":"Maras","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saggere M.","family":"Shasthry","sequence":"additional","affiliation":[{"name":"Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Nayak","sequence":"additional","affiliation":[{"name":"Nephrology, Institute of Liver and Biliary Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Arora","sequence":"additional","affiliation":[{"name":"Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Vijayaraghavan","sequence":"additional","affiliation":[{"name":"Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shvetank","family":"Sharma","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[{"name":"Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv K.","family":"Sarin","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Medicine"},{"name":"Hepatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230913","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.3390\/biom5042978","article-title":"Update on alcoholic hepatitis","volume":"5","author":"Torok","year":"2015","journal-title":"Biomolecules"},{"key":"R2-20230913","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"R3-20230913","doi-asserted-by":"crossref","first-page":"17756","DOI":"10.3748\/wjg.v20.i47.17756","article-title":"Pathogenesis of alcoholic liver disease: role of oxidative metabolism","volume":"20","author":"Ceni","year":"2014","journal-title":"World J Gastroenterol"},{"key":"R4-20230913","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol Rev"},{"key":"R5-20230913","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1046\/j.1523-1755.2001.00807.x","article-title":"Albumin is the major plasma protein target of oxidant stress in uremia","volume":"60","author":"Himmelfarb","year":"2001","journal-title":"Kidney Int"},{"key":"R6-20230913","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/hep.28897","article-title":"Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis","volume":"65","author":"Das","year":"2017","journal-title":"Hepatology"},{"key":"R7-20230913","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1016\/j.bbagen.2013.04.036","article-title":"Redox properties of serum albumin","volume":"1830","author":"Anraku","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"R8-20230913","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1021\/ac902322w","article-title":"Increased oxidative modifications of amniotic fluid albumin in pregnancies associated with gestational diabetes mellitus","volume":"82","author":"Boisvert","year":"2010","journal-title":"Anal Chem"},{"issue":"suppl 1","key":"R9-20230913","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/S0168-8278(12)60005-1","article-title":"Management of alcoholic hepatitis","volume":"56","author":"Mathurin","year":"2012","journal-title":"J Hepatol"},{"key":"R10-20230913","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1172\/JCI109433","article-title":"Transport of steroid hormones through the rat blood-brain barrier. 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