{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:51:23Z","timestamp":1785775883901,"version":"3.56.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1097\/mcg.0b013e318267b55d","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T01:54:37Z","timestamp":1346896477000},"page":"S18-S26","source":"Crossref","is-referenced-by-count":35,"title":["The Innovative Potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to Restore the \u201cGastric Barrier Effect\u201d in Patients Chronically Treated With PPI"],"prefix":"10.1097","volume":"46","author":[{"given":"Mario","family":"Del Piano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Anderloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Balzarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ballar\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Carmagnola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Montino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Orsello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pagliarulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Tari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Soattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Sforza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Mogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210305","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(03)12489-0","article-title":"Gut flora in health and disease.","volume":"361","author":"Guarner","year":"2003","journal-title":"Lancet"},{"key":"R2-6-20210305","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/bega.2001.0184","article-title":"Pharmacological and pharmacodynamic essentials of H2 receptor antagonists and proton pump inhibitors for the practicing physician.","volume":"15","author":"Huang","year":"2001","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"R3-6-20210305","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/gut.33.5.617","article-title":"Effects of omeprazole on neutrophil chemotaxis, superoxide production, degranulation and translocation on cytochrome b-245.","volume":"33","author":"Wandall","year":"1992","journal-title":"Gut"},{"key":"R4-6-20210305","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/gut.8.6.574","article-title":"Influence of gastric pH on gastric and jejunal flora.","volume":"8","author":"Gray","year":"1967","journal-title":"Gut"},{"key":"R5-6-20210305","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/bega.2001.0189","article-title":"Gastric mucosal morphological consequences of acid suppression: a balance view.","volume":"15","author":"Meuwissen","year":"2001","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"suppl 111","key":"R6-6-20210305","first-page":"111","article-title":"Normal and pathological microbial of the upper gastro-intestinal tract.","volume":"20","author":"Hill","year":"1984","journal-title":"Scand J Gastroenterol"},{"key":"R7-6-20210305","first-page":"359","article-title":"Bacterial changes in the small intestine in malabsorption states and in pernicious anaemia.","volume":"26","author":"Dellipiani","year":"1964","journal-title":"Clin Sci"},{"key":"R8-6-20210305","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1053\/gast.2000.9367","article-title":"Omeprazole, Helicobacter pylori status and alteration in the intragastric milieu facilitating bacterial N-nitrosation.","volume":"119","author":"Mowat","year":"2000","journal-title":"Gastroenterology"},{"key":"R10-6-20210305","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrmicro2298","article-title":"The population genetics of commensal Escherichia coli.","volume":"8","author":"Tenaillon","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"R11-6-20210305","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MOG.0b013e3282f2dfb8","article-title":"Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections.","volume":"24","author":"Serna","year":"2008","journal-title":"Curr Opin Gastroenterol"},{"key":"R12-6-20210305","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/fpd.2010.0673","article-title":"Escherichia coli O157:H7: animal reservoir and sources of human infection.","volume":"8","author":"Ferens","year":"2011","journal-title":"Foodborne Pathog Dis"},{"key":"R13-6-20210305","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process. First American Cancer society award lecture in cancer epidemiology and prevention.","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res"},{"key":"R15-6-20210305","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/gast.2002.30298","article-title":"Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice.","volume":"122","author":"Zavros","year":"2002","journal-title":"Gastroenterology"},{"key":"R16-6-20210305","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJM199604183341603","article-title":"Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication.","volume":"334","author":"Kuipers","year":"1996","journal-title":"N Engl J Med"},{"key":"R17-6-20210305","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/gast.1999.0029900319","article-title":"Lack of effect of acid suppression therapy on gastric atrophy. Nordic Gerd study group.","volume":"117","author":"Lundell","year":"1999","journal-title":"Gastroenterology"},{"key":"R18-6-20210305","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0016-5085(00)70135-1","article-title":"Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa.","volume":"118","author":"Klinkenberg-Knol","year":"2000","journal-title":"Gastroenterology"},{"key":"R19-6-20210305","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1046\/j.1365-2036.2001.01029.x","article-title":"Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis.","volume":"15","author":"Sanduleanu","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"R20-6-20210305","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/bmj.2.3849.665","article-title":"The clinical importance of achlorhydria.","volume":"2","author":"Hurst","year":"1934","journal-title":"Br Med J"},{"key":"R21-6-20210305","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1056\/NEJMoa1012413","article-title":"Host and pathogen factors for Clostridium difficile infection and colonization.","volume":"365","author":"Loo","year":"2011","journal-title":"N Engl J Med"},{"key":"R22-6-20210305","doi-asserted-by":"crossref","first-page":"e817","DOI":"10.1542\/peds.2005-1655","article-title":"Working Group on Intestinal Infections of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP). Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.","volume":"117","author":"Canani","year":"2006","journal-title":"Pediatrics"},{"key":"R23-6-20210305","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/gut.35.1.23","article-title":"Duodenal bacterial overgrowth during treatment in outpatients with omeprazole.","volume":"35","author":"Fried","year":"1994","journal-title":"Gut"},{"key":"R24-6-20210305","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/AEM.66.1.297-303.2000","article-title":"Detection and identification of gastrointestinal Lactobacillus species by using denaturing gradient gel electrophoresis and species-specific PCR primers.","volume":"66","author":"Walter","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"R25-6-20210305","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1128\/JCM.42.7.3128-3136.2004","article-title":"Quantitative analysis of diverse Lactobacillus species present in advanced dental caries.","volume":"42","author":"Byun","year":"2004","journal-title":"J Clin Microbiol"},{"key":"R26-6-20210305","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1128\/AEM.67.8.3450-3454.2001","article-title":"Differentiation of Lactobacillus plantarum, L. pentosus, and L. paraplantarum by recA gene sequence analysis and multiplex PCR assay with recA gene-derived primers.","volume":"67","author":"Torriani","year":"2001","journal-title":"Appl Environ Microbiol"},{"key":"R27-6-20210305","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1128\/AEM.67.9.4137-4143.2001","article-title":"Survival of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus in the terminal ileum of fistulated Gottingen minipigs.","volume":"67","author":"Lick","year":"2001","journal-title":"Appl Environ Microbiol"},{"key":"R29-6-20210305","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MCG.0b013e3182333820","article-title":"Recent safety concerns with proton pump inhibitors.","volume":"46","author":"Chen","year":"2012","journal-title":"J Clin Gastroenterol"},{"key":"R30-6-20210305","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.amjmed.2011.01.007","article-title":"Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies.","volume":"124","author":"Yu","year":"2011","journal-title":"Am J Med"},{"key":"R31-6-20210305","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s10620-010-1560-3","article-title":"Adverse effects of long-term proton pump inhibitor therapy.","volume":"56","author":"Sheen","year":"2011","journal-title":"Dig Dis Sci"},{"key":"R32-6-20210305","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1001\/jama.292.16.1955","article-title":"Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.","volume":"292","author":"Laheij","year":"2004","journal-title":"JAMA"},{"key":"R33-6-20210305","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1001\/archinte.167.9.950","article-title":"Use of proton pump inhibitors and the risk of community-acquired pneumonia: a population-based case-control study.","volume":"167","author":"Gulmez","year":"2007","journal-title":"Arch Intern Med"},{"key":"R34-6-20210305","doi-asserted-by":"crossref","first-page":"114","DOI":"10.5694\/j.1326-5377.2009.tb02307.x","article-title":"Proton-pump inhibitors and the risk of antibiotic use and hospitalisation for pneumonia.","volume":"190","author":"Roughead","year":"2009","journal-title":"Med J Aust"},{"key":"R36-6-20210305","doi-asserted-by":"crossref","first-page":"752","DOI":"10.5301\/ijao.5000024","article-title":"Role of antibiofilm-antimicrobial agents in controlling device-related infections.","volume":"34","author":"Aslam","year":"2011","journal-title":"Int J Artif Organs"},{"key":"R37-6-20210305","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/JCM.15.4.703-713.1982","article-title":"Atypical biogroups of Escherichia coli found in clinical specimens and description of Escherichia hermannii sp. nov.","volume":"15","author":"Brenner","year":"1982","journal-title":"J Clin Microbiol"},{"key":"R39-6-20210305","first-page":"485","article-title":"Acute appendicitis due to both Klebsiella pneumoniae and serotype 35B Streptococcus pneumoniae, an emergent serotype.","volume":"69","author":"Gerome","year":"2011","journal-title":"Ann Biol Clin (Paris)"},{"key":"R40-6-20210305","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1128\/JCM.01741-09","article-title":"Cytotoxic effects of Klebsiella oxytoca strains isolated from patients with antibiotic-associated hemorrhagic colitis or other diseases caused by infections and from healthy subjects.","volume":"48","author":"Joainig","year":"2010","journal-title":"J Clin Microbiol"},{"key":"R41-6-20210305","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijantimicag.2010.09.009","article-title":"Risk factors and outcome of extended-spectrum -lactamase-producing Enterobacter cloacae bloodstream infections.","volume":"37","author":"Qureshi","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"R42-6-20210305","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1046\/j.1525-1381.1999.99241.x","article-title":"Enterococci: new aspects of an old organism.","volume":"111","author":"Murray","year":"1999","journal-title":"Proc Assoc Am Physicians"},{"key":"R43-6-20210305","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMp0804651","article-title":"Antibiotic-resistant bugs in the 21st centurya clinical super-challenge.","volume":"360","author":"Arias","year":"2009","journal-title":"N Engl J Med"},{"key":"R44-6-20210305","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1574-695X.2008.00383.x","article-title":"Emergence of CC17 Enterococcus faecium: from commensal to hospital-adapted pathogen.","volume":"52","author":"Top","year":"2008","journal-title":"FEMS Immunol Med Microbiol"}],"container-title":["Journal of Clinical Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00004836-201210001-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T06:28:19Z","timestamp":1618036099000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00004836-201210001-00006"}},"subtitle":["A Pilot Study"],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1097\/mcg.0b013e318267b55d","relation":{},"ISSN":["0192-0790"],"issn-type":[{"value":"0192-0790","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}