{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:14:30Z","timestamp":1786119270063,"version":"build-2736575974"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Clinical Nutrition and Metabolic Care"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1097\/mco.0b013e32832c7819","type":"journal-article","created":{"date-parts":[[2009,6,8]],"date-time":"2009-06-08T03:19:59Z","timestamp":1244431199000},"page":"404-411","source":"Crossref","is-referenced-by-count":36,"title":["The metabolic syndrome: how it may influence hepatic stellate cell activation and hepatic fibrosis"],"prefix":"10.1097","volume":"12","author":[{"given":"Nicolas","family":"Lanthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Horsmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle A","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20090608","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hep.20280","volume":"40","author":"Hui","year":"2004","journal-title":"Hepatology"},{"key":"R2-13-20090608","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/hep.20023","volume":"39","author":"Bugianesi","year":"2004","journal-title":"Hepatology"},{"key":"R3-13-20090608","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hep.21711","volume":"46","author":"Bedossa","year":"2007","journal-title":"Hepatology"},{"key":"R4-13-20090608","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"R5-13-20090608","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"R6-13-20090608","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/jhep.2001.28055","volume":"34","author":"Paradis","year":"2001","journal-title":"Hepatology"},{"key":"R7-13-20090608","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep.510300425","volume":"30","author":"Paradis","year":"1999","journal-title":"Hepatology"},{"key":"R8-13-20090608","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jhep.2007.04.002","volume":"47","author":"Leclercq","year":"2007","journal-title":"J Hepatol"},{"key":"R9-13-20090608","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1872-034X.2008.00485.x","volume":"39","author":"Bechmann","year":"2009","journal-title":"Hepatol Res"},{"key":"R10-13-20090608","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2174\/138161208784139701","volume":"14","author":"Hyogo","year":"2008","journal-title":"Curr Pharm Des"},{"key":"R11-13-20090608","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1053\/jhep.2001.28788","volume":"34","author":"Fehrenbach","year":"2001","journal-title":"Hepatology"},{"key":"R12-13-20090608","first-page":"A01","volume":"72","author":"Guimaraes","year":"2009","journal-title":"Acta Gastroenterol Belg"},{"key":"R13-13-20090608","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s00535-007-2152-7","volume":"43","author":"Iwamoto","year":"2008","journal-title":"J Gastroenterol"},{"key":"R14-13-20090608","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2147\/VHRM.S1991","volume":"4","author":"Ban","year":"2008","journal-title":"Vasc Health Risk Manag"},{"key":"R15-13-20090608","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.cld.2008.07.005","volume":"12","author":"Urtasun","year":"2008","journal-title":"Clin Liver Dis"},{"key":"R16-13-20090608","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1002\/hep.20973","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"key":"R17-13-20090608","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1124\/pr.108.00001","volume":"60","author":"Anderson","year":"2008","journal-title":"Pharmacol Rev"},{"key":"R18-13-20090608","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1111\/j.1440-1746.2006.04640.x","volume":"22","author":"Pessayre","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"R19-13-20090608","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","volume":"116","author":"Shoelson","year":"2006","journal-title":"J Clin Invest"},{"key":"R20-13-20090608","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI24335","volume":"116","author":"Weisberg","year":"2006","journal-title":"J Clin Invest"},{"key":"R21-13-20090608","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","volume":"117","author":"Lumeng","year":"2007","journal-title":"J Clin Invest"},{"key":"R22-13-20090608","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1172\/JCI30992","volume":"117","author":"Gordon","year":"2007","journal-title":"J Clin Invest"},{"key":"R23-13-20090608","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pathophys.2008.05.001","volume":"15","author":"Bertolani","year":"2008","journal-title":"Pathophysiology"},{"key":"R24-13-20090608","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature01705","volume":"423","author":"Yamauchi","year":"2003","journal-title":"Nature"},{"key":"R25-13-20090608","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1111\/j.1572-0241.2005.00297.x","volume":"100","author":"Musso","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"R26-13-20090608","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-2265.2006.02527.x","volume":"64","author":"Targher","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R27-13-20090608","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/gut.2003.037010","volume":"54","author":"Kaser","year":"2005","journal-title":"Gut"},{"key":"R28-13-20090608","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1053\/j.gastro.2003.08.029","volume":"125","author":"Kamada","year":"2003","journal-title":"Gastroenterology"},{"key":"R29-13-20090608","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)62476-5","volume":"166","author":"Ding","year":"2005","journal-title":"Am J Pathol"},{"key":"R30-13-20090608","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.21991","volume":"47","author":"Adachi","year":"2008","journal-title":"Hepatology"},{"key":"R31-13-20090608","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/hep.21995","volume":"47","author":"Caligiuri","year":"2008","journal-title":"Hepatology"},{"key":"R32-13-20090608","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1301\/002966402320634878","volume":"60","author":"Friedman","year":"2002","journal-title":"Nutr Rev"},{"key":"R33-13-20090608","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s10620-006-9126-0","volume":"51","author":"Bethanis","year":"2006","journal-title":"Dig Dis Sci"},{"key":"R34-13-20090608","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0168-8278(02)00102-2","volume":"37","author":"Leclercq","year":"2002","journal-title":"J Hepatol"},{"key":"R35-13-20090608","doi-asserted-by":"crossref","first-page":"G1035","DOI":"10.1152\/ajpgi.00199.2004","volume":"287","author":"Sahai","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R36-13-20090608","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/bbrc.1997.8193","volume":"244","author":"Potter","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"R37-13-20090608","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cld.2008.07.003","volume":"12","author":"van der Poorten","year":"2008","journal-title":"Clin Liver Dis"},{"key":"R38-13-20090608","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0016-5085(00)70368-4","volume":"118","author":"Bataller","year":"2000","journal-title":"Gastroenterology"},{"key":"R39-13-20090608","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cld.2008.07.013","volume":"12","author":"Moreno","year":"2008","journal-title":"Clin Liver Dis"},{"key":"R40-13-20090608","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jhep.2005.02.034","volume":"43","author":"Yang","year":"2005","journal-title":"J Hepatol"},{"key":"R41-13-20090608","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbrc.2006.05.183","volume":"346","author":"Nabeshima","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"R42-13-20090608","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1053\/j.gastro.2006.12.036","volume":"132","author":"Colmenero","year":"2007","journal-title":"Gastroenterology"},{"key":"R43-13-20090608","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0168-8278(03)00459-8","volume":"39","author":"Dixon","year":"2003","journal-title":"J Hepatol"},{"key":"R44-13-20090608","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/hep.20420","volume":"40","author":"Yokohama","year":"2004","journal-title":"Hepatology"},{"key":"R45-13-20090608","doi-asserted-by":"crossref","first-page":"33021","DOI":"10.1074\/jbc.R800012200","volume":"283","author":"Kunos","year":"2008","journal-title":"J Biol Chem"},{"key":"R46-13-20090608","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2826.2008.01679.x","volume":"20","author":"Caraceni","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"R47-13-20090608","doi-asserted-by":"crossref","first-page":"G1101","DOI":"10.1152\/ajpgi.00057.2008","volume":"294","author":"Kunos","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R48-13-20090608","doi-asserted-by":"crossref","first-page":"G9","DOI":"10.1152\/ajpgi.00467.2007","volume":"294","author":"Mallat","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R49-13-20090608","doi-asserted-by":"crossref","first-page":"G357","DOI":"10.1152\/ajpgi.00456.2007","volume":"294","author":"Siegmund","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R50-13-20090608","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hep.20667","volume":"41","author":"Siegmund","year":"2005","journal-title":"Hepatology"},{"key":"R51-13-20090608","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1053\/j.gastro.2004.12.050","volume":"128","author":"Julien","year":"2005","journal-title":"Gastroenterology"},{"key":"R52-13-20090608","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nm1421","volume":"12","author":"Teixeira-Clerc","year":"2006","journal-title":"Nat Med"},{"key":"R53-13-20090608","doi-asserted-by":"crossref","first-page":"993","DOI":"10.2353\/ajpath.2008.070720","volume":"173","author":"DeLeve","year":"2008","journal-title":"Am J Pathol"},{"key":"R54-13-20090608","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/hep.20733","volume":"42","author":"Hezode","year":"2005","journal-title":"Hepatology"},{"key":"R55-13-20090608","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1074\/jbc.M308351200","volume":"279","author":"Cao","year":"2004","journal-title":"J Biol Chem"},{"key":"R56-13-20090608","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jhep.2006.07.027","volume":"46","author":"Cao","year":"2007","journal-title":"J Hepatol"},{"key":"R57-13-20090608","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clim.2008.08.008","volume":"130","author":"Notas","year":"2009","journal-title":"Clin Immunol"},{"key":"R58-13-20090608","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhep.2005.12.025","volume":"45","author":"Melhem","year":"2006","journal-title":"J Hepatol"},{"key":"R59-13-20090608","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","volume":"130","author":"Radaeva","year":"2006","journal-title":"Gastroenterology"},{"key":"R60-13-20090608","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"R61-13-20090608","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature03918","volume":"436","author":"Chen","year":"2005","journal-title":"Nature"},{"key":"R62-13-20090608","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/path.1869","volume":"208","author":"Elinav","year":"2006","journal-title":"J Pathol"},{"key":"R63-13-20090608","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jhep.2008.05.025","volume":"49","author":"Ma","year":"2008","journal-title":"J Hepatol"},{"key":"R64-13-20090608","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/path.1950","volume":"209","author":"Elinav","year":"2006","journal-title":"J Pathol"},{"key":"R65-13-20090608","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/hep.22813","volume":"49","author":"Park","year":"2009","journal-title":"Hepatology"}],"container-title":["Current Opinion in Clinical Nutrition and Metabolic Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MCO.0b013e32832c7819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:54:49Z","timestamp":1786038889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00075197-200907000-00013"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":65,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1097\/mco.0b013e32832c7819","relation":{},"ISSN":["1363-1950"],"issn-type":[{"value":"1363-1950","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}