{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:16:35Z","timestamp":1787062595072,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1097\/mcp.0b013e32833c645d","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T03:36:30Z","timestamp":1277782590000},"page":"516-520","source":"Crossref","is-referenced-by-count":46,"title":["Oxidative stress and antioxidants in interstitial lung disease"],"prefix":"10.1097","volume":"16","author":[{"given":"Aalt","family":"Bast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje R","family":"Weseler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido RMM","family":"Haenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertjan JM","family":"den Hartog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20210206","first-page":"496","article-title":"Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways. Eur Respir J 2003; 22:457-461.","volume":"23","author":"Ichinose","year":"2004","journal-title":"Erratum in: Eur Respir J"},{"key":"R2-20-20210206","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/clpt.1994.173","article-title":"Caffeine metabolism in cystic fibrosis: enhanced xanthine oxidase activity","volume":"56","author":"Hamelin","year":"1994","journal-title":"Clin Pharmacol Ther"},{"key":"R3-20-20210206","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2005","article-title":"NADPH oxidase-4 mediates myofibroblasts activation and fibrogenic responses to lung injury","volume":"15","author":"Hecker","year":"2009","journal-title":"Nat Med"},{"key":"R4-20-20210206","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.drudis.2006.04.003","article-title":"Vascular NADPH oxidases as drug targets for novel antioxidant strategies.","volume":"11-","author":"Guzlik","year":"2006","journal-title":"Drug Discov Today"},{"key":"R5-20-20210206","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1440-1681.2007.04830.x","article-title":"Endothelins and NADPH oxidases in the cardiovascular system","volume":"35","author":"Dammanahalli","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"R6-20-20210206","doi-asserted-by":"crossref","first-page":"17858","DOI":"10.1074\/jbc.M809761200","article-title":"ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli","volume":"284","author":"Boots","year":"2009","journal-title":"J Biol Chem"},{"key":"R7-20-20210206","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1365-2362.2006.01636.x","article-title":"Exhaled markers of oxidative stress in idiopathic pulmonary fibrosis","volume":"36","author":"Psathakis","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"R8-20-20210206","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/10715760500522648","article-title":"Free radicals in exhaled breath condensate in cystic fibrosis and healthy subjects","volume":"40","author":"Rosias","year":"2006","journal-title":"Free Radic Res"},{"key":"R9-20-20210206","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1164\/ajrccm.156.6.9706065","article-title":"Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression","volume":"156","author":"Behr","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"R10-20-20210206","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.rmed.2008.10.007","article-title":"Antioxidant status associated with inflammation in sarcoidosis: a potential role for antioxidants","volume":"103","author":"Boots","year":"2009","journal-title":"Respir Med"},{"key":"R11-20-20210206","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1165\/ajrcmb.21.1.3379","article-title":"Reactive oxygen and nitrogen intermediates increase transforming growth factor-beta1 release from human epithelial alveolar cells through two different mechanisms","volume":"21","author":"Bellocq","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"R12-20-20210206","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.freeradbiomed.2005.10.054","article-title":"The role of oxidative stress in adult critical care","volume":"40","author":"Crimi","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"R13-20-20210206","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.2165\/0002018-200831120-00008","article-title":"Role of cytochrome P450 polymorphisms in the development of pulmonary toxicity. A case-control study in the Netherlands","volume":"31","author":"Wijnen","year":"2008","journal-title":"Drug Saf"},{"key":"R14-20-20210206","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF03256350","article-title":"Variant VKORC1 and CYP2C9 alleles in patients with diffuse alveolar hemorrhage caused by oral anticoagulants","volume":"14","author":"Wijnen","year":"2010","journal-title":"Mol Diagn Ther"},{"key":"R15-20-20210206","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1096\/fj.03-1127fje","article-title":"The transcription factor NRF2 protects against pulmonary fibrosis","volume":"18","author":"Cho","year":"2004","journal-title":"FASEB J"},{"key":"R16-20-20210206","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1164\/ajrccm.158.6.9804105","article-title":"Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis","volume":"158","author":"Tobin","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"R17-20-20210206","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.rmed.2008.11.001","article-title":"Role of diabetes mellitus and gastro-oesophageal reflux in the aetiology of idiopathic pulmonary fibrosis","volume":"103","author":"Gribbin","year":"2009","journal-title":"Respir Med"},{"key":"R18-20-20210206","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2008.04.062","article-title":"Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin, on experimental reflux oesophagitis in rats","volume":"589","author":"Rao","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"R19-20-20210206","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2958","article-title":"Strategies for treating idiopathic pulmonary fibrosis","volume":"9","author":"Du Bois","year":"2010","journal-title":"Nat Rev Drug Disc"},{"key":"R20-20-20210206","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1465-9921-10-101","article-title":"Lung function in idiopathic pulmonary fibrosis: extended analyses of the IFIGENIA trial","volume":"10","author":"Behr","year":"2009","journal-title":"Respir Res"},{"key":"R21-20-20210206","first-page":"409","article-title":"\u03b1-Lipoic acid and N-acetylcysteine: new concepts for old drugs","author":"Bast","year":"1995"},{"key":"R22-20-20210206","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1056\/NEJMoa042976","article-title":"High-dose acetylcysteine in idiopathic pulmonary fibrosis","volume":"353","author":"Demedts","year":"2005","journal-title":"N Engl J Med"},{"key":"R23-20-20210206","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1164\/rccm.200404-571OC","article-title":"Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis","volume":"171","author":"Azuma","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R24-20-20210206","first-page":"966","article-title":"First drug for idiopathic pulmonary fibrosis approved in Japan.","volume":"7","year":"2008","journal-title":"Nat Rev Drug Disc"},{"key":"R25-20-20210206","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejphar.2008.06.110","article-title":"Potent antioxidant role of pirfenidone in experimental cirrhosis","volume":"595","author":"Salazar-Montes","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"R26-20-20210206","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbrc.2008.04.093","article-title":"Superoxide scavenging activity of pirfenidone-iron complex","volume":"372","author":"Mitani","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"R27-20-20210206","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0891-5849(89)90066-X","article-title":"The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid","volume":"6","author":"Aruoma","year":"1989","journal-title":"Free Radic Biol Med"},{"key":"R28-20-20210206","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.taap.2009.02.019","article-title":"Superoxide radicals increase transforming growth factor-beta1 and collagen release from human lung fibroblasts via cellular influx through chloride channels","volume":"237","author":"Qi","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"R29-20-20210206","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrd2780","article-title":"Chloride channels as drug targets","volume":"8","author":"Verkman","year":"2009","journal-title":"Nat Rev Drug Disc"},{"key":"R30-20-20210206","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/rccm.200501-017PP","article-title":"Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy","volume":"172","author":"Kinnula","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R31-20-20210206","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","article-title":"Health effects of quercetin: from antioxidant to nutraceutical","volume":"585","author":"Boots","year":"2008","journal-title":"Eur J Pharmacol"}],"container-title":["Current Opinion in Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MCP.0b013e32833c645d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:23:35Z","timestamp":1786040615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00063198-201009000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/mcp.0b013e32833c645d","relation":{},"ISSN":["1070-5287"],"issn-type":[{"value":"1070-5287","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}