{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:58:57Z","timestamp":1783090737761,"version":"3.54.6"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1097\/md.0000000000000007","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T12:58:31Z","timestamp":1382360311000},"page":"295-304","source":"Crossref","is-referenced-by-count":28,"title":["High Prevalence of Prothrombotic Abnormalities in Multifocal Osteonecrosis"],"prefix":"10.1097","volume":"92","author":[{"given":"Jose A.","family":"G\u00f3mez-Puerta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Peris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Carles","family":"Reverter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Martinez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Monegal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Monteagudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"T\u00e0ssies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Gua\u00f1abens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20210226","first-page":"297","article-title":"Kienbocks disease and antiphospholipid antibodies.","volume":"8","author":"Alijotas","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"R2-1-20210226","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/00003086-199912000-00033","article-title":"Symptomatic multifocal osteonecrosis. A multicenter study. Collaborative Osteonecrosis Group.","volume":"369","year":"1999","journal-title":"Clin Orthop Relat Res"},{"key":"R3-1-20210226","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00005792-198911000-00004","article-title":"The primary antiphospholipid syndrome: major clinical and serological features.","volume":"68","author":"Asherson","year":"1989","journal-title":"Medicine (Baltimore)"},{"key":"R4-1-20210226","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","article-title":"Pathogenesis and natural history of osteonecrosis.","volume":"32","author":"Assouline-Dayan","year":"2002","journal-title":"Semin Arthritis Rheum"},{"key":"R5-1-20210226","first-page":"1469","article-title":"Femoral head necrosis and hyperhomocysteinemia.","volume":"28","author":"Blanche","year":"2001","journal-title":"J Rheumatol"},{"key":"R6-1-20210226","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.transproceed.2005.12.062","article-title":"Association of corticosteroids and factor V, prothrombin, and MTHFR gene mutations with avascular osteonecrosis in renal allograft recipients.","volume":"38","author":"Celik","year":"2006","journal-title":"Transplant Proc"},{"key":"R7-1-20210226","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/17453674.2011.555368","article-title":"Idiopathic and secondary osteonecrosis of the femoral head show different thrombophilic changes and normal or higher levels of platelet growth factors.","volume":"82","author":"Cenni","year":"2011","journal-title":"Acta Orthop"},{"key":"R8-1-20210226","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/art.10187","article-title":"Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients.","volume":"46","author":"Cervera","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"Suppl 6","key":"R9-1-20210226","first-page":"S141","article-title":"The prevalence of thrombophilia in idiopathic osteonecrosis of the hip.","volume":"92","author":"Chotanaphuti","year":"2009","journal-title":"J Med Assoc Thai"},{"key":"R10-1-20210226","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/1076029607310217","article-title":"Thrombophilia in human immunodeficiency virus-infected patients with osteonecrosis: is there a real connection The first case-control study.","volume":"15","author":"de Larranaga","year":"2009","journal-title":"Clin Appl Thromb Hemost"},{"key":"R11-1-20210226","first-page":"2376","article-title":"Catastrophic antiphospholipid antibody syndrome presenting with multiple thromboses and sites of avascular necrosis.","volume":"21","author":"Egan","year":"1994","journal-title":"J Rheumatol"},{"key":"R12-1-20210226","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/art.22663","article-title":"Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals.","volume":"56","author":"Erkan","year":"2007","journal-title":"Arthritis Rheum"},{"key":"R13-1-20210226","first-page":"2817","article-title":"Primary antiphospholipid syndrome: functional outcome after 10 years.","volume":"27","author":"Erkan","year":"2000","journal-title":"J Rheumatol"},{"key":"R14-1-20210226","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/1874325000903010032","article-title":"Multifocal joint osteonecrosis in sickle cell disease.","volume":"3","author":"Flouzat-Lachaniete","year":"2009","journal-title":"Open Orthop J"},{"key":"R15-1-20210226","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1399-0004.1997.tb02548.x","article-title":"Factor V Leiden (R506Q) and risk of venous thromboembolism: a case-control study based on the Spanish population.","volume":"52","author":"Garcia-Gala","year":"1997","journal-title":"Clin Genet"},{"key":"R16-1-20210226","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1191\/0961203303lu411oa","article-title":"Outcome of primary antiphospholipid syndrome in childhood.","volume":"12","author":"Gattorno","year":"2003","journal-title":"Lupus"},{"key":"R17-1-20210226","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00003086-199909000-00017","article-title":"The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis.","volume":"366","author":"Glueck","year":"1999","journal-title":"Clin Orthop Relat Res"},{"key":"R18-1-20210226","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2106\/JBJS.G.00616","article-title":"Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis.","volume":"90","author":"Glueck","year":"2008","journal-title":"J Bone Joint Surg Am"},{"key":"R19-1-20210226","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/1076029612449901","article-title":"The role of the factor V Leiden mutation in osteonecrosis of the hip.","volume":"19","author":"Glueck","year":"2013","journal-title":"Clin Appl Thromb Hemost"},{"key":"R20-1-20210226","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.2106\/00004623-200711000-00018","article-title":"Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur.","volume":"89","author":"Glueck","year":"2007","journal-title":"J Bone Joint Surg Am"},{"key":"R21-1-20210226","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s11999-008-0148-0","article-title":"Heritable thrombophilia-hypofibrinolysis and osteonecrosis of the femoral head.","volume":"466","author":"Glueck","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"R22-1-20210226","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1079-2104(98)90400-0","article-title":"A preliminary pilot study of treatment of thrombophilia and hypofibrinolysis and amelioration of the pain of osteonecrosis of the jaws.","volume":"85","author":"Glueck","year":"1998","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R23-1-20210226","first-page":"225","article-title":"Long-term follow-up in 128 patients with primary antiphospholipid syndrome: do they develop lupus Medicine (Baltimore).","volume":"84","author":"Gomez-Puerta","year":"2005","journal-title":""},{"key":"R24-1-20210226","first-page":"185","article-title":"Osteonecrosis multiple. Patogenesis, caracteristicas clinicas y tratamiento.","volume":"8","author":"Gomez-Puerta","year":"2007","journal-title":"Semin Fund Esp Reumatol"},{"key":"R25-1-20210226","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/157339710790827722","article-title":"Skeletal involvement in antiphospholipid syndrome.","volume":"6","author":"Gomez-Puerta","year":"2010","journal-title":"Curr Rheumatol Rev"},{"key":"R27-1-20210226","first-page":"783","article-title":"Procoagulants and osteonecrosis.","volume":"30","author":"Jones","year":"2003","journal-title":"J Rheumatol"},{"key":"R28-1-20210226","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-0037-1614985","article-title":"Familial clustering of factor VIII and von Willebrand factor levels.","volume":"79","author":"Kamphuisen","year":"1998","journal-title":"Thromb Haemost"},{"key":"R29-1-20210226","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.ahj.2010.02.020","article-title":"Increased risk for coronary heart disease after avascular necrosis of femoral head: a 3-year follow-up study.","volume":"159","author":"Kang","year":"2010","journal-title":"Am Heart J"},{"key":"R30-1-20210226","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/jor.20164","article-title":"Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis.","volume":"24","author":"Koo","year":"2006","journal-title":"J Orthop Res"},{"key":"R31-1-20210226","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.amjmed.2006.02.016","article-title":"High FVIII level is associated with idiopathic portal vein thrombosis in South India.","volume":"120","author":"Koshy","year":"2007","journal-title":"Am J Med"},{"key":"R32-1-20210226","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0140-6736(95)90166-3","article-title":"Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis.","volume":"345","author":"Koster","year":"1995","journal-title":"Lancet"},{"key":"R33-1-20210226","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJM200008173430702","article-title":"High plasma levels of factor VIII and the risk of recurrent venous thromboembolism.","volume":"343","author":"Kyrle","year":"2000","journal-title":"N Engl J Med"},{"key":"R34-1-20210226","first-page":"1968","article-title":"Multifocal osteonecrosis.","volume":"25","author":"LaPorte","year":"1998","journal-title":"J Rheumatol"},{"key":"R35-1-20210226","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/thoraxjnl-2011-201076","article-title":"Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary embolideep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia.","volume":"67","author":"Livesey","year":"2012","journal-title":"Thorax"},{"key":"R36-1-20210226","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1055\/s-2007-994939","article-title":"Sticky platelet syndrome.","volume":"25","author":"Mammen","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"R37-1-20210226","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jbspin.2008.04.019","article-title":"Coagulopathies frequency in aseptic osteonecrosis patients.","volume":"76","author":"Mehsen","year":"2009","journal-title":"Joint Bone Spine"},{"key":"R38-1-20210226","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s10067-007-0818-4","article-title":"Primary antiphospholipid syndrome in Latin American mestizo patients: clinical and immunologic characteristics and comparison with European patients.","volume":"27","author":"Mejia-Romero","year":"2008","journal-title":"Clin Rheumatol"},{"key":"R39-1-20210226","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7326\/0003-4819-137-1-200207020-00008","article-title":"High prevalence of osteonecrosis of the femoral head in HIV-infected adults.","volume":"137","author":"Miller","year":"2002","journal-title":"Ann Intern Med"},{"key":"R40-1-20210226","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS).","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"key":"R41-1-20210226","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","article-title":"Non-traumatic avascular necrosis of the femoral head.","volume":"77","author":"Mont","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"R42-1-20210226","first-page":"1629","article-title":"Bone scanning of limited value for diagnosis of symptomatic oligofocal and multifocal osteonecrosis.","volume":"35","author":"Mont","year":"2008","journal-title":"J Rheumatol"},{"key":"R43-1-20210226","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1086\/511683","article-title":"The incidence and natural history of osteonecrosis in HIV-infected adults.","volume":"44","author":"Morse","year":"2007","journal-title":"Clin Infect Dis"},{"key":"R44-1-20210226","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1191\/0961203306lu2301cr","article-title":"Multifocal avascular necrosis after liver transplantation: an unusual presentation of the antiphospholipid syndrome.","volume":"15","author":"Mundo","year":"2006","journal-title":"Lupus"},{"key":"R45-1-20210226","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/BOR.0b013e32832c9d04","article-title":"Rheumatic manifestations associated with HIV in the highly active antiretroviral therapy era.","volume":"21","author":"Nguyen","year":"2009","journal-title":"Curr Opin Rheumatol"},{"key":"R46-1-20210226","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-0037-1613748","article-title":"Elevation of FVIII:C in venous thromboembolism is persistent and independent of the acute phase response.","volume":"83","author":"ODonnell","year":"2000","journal-title":"Thromb Haemost"},{"key":"R47-1-20210226","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1055\/s-0038-1656061","article-title":"High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction.","volume":"77","author":"ODonnell","year":"1997","journal-title":"Thromb Haemost"},{"key":"R48-1-20210226","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1253\/circj.CJ-10-1051","article-title":"High plasma level of factor VIII: an important risk factor for venous thromboembolism.","volume":"75","author":"Ota","year":"2011","journal-title":"Circ J"},{"key":"R49-1-20210226","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2009.03674.x","article-title":"Clinical course of high-risk patients diagnosed with antiphospholipid syndrome.","volume":"8","author":"Pengo","year":"2010","journal-title":"J Thromb Haemost"},{"key":"R50-1-20210226","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/RHU.0b013e3181e9345d","article-title":"Avascular necrosis of the metacarpals in juvenile dermatomyositis.","volume":"16","author":"Robinson","year":"2010","journal-title":"J Clin Rheumatol"},{"key":"R51-1-20210226","first-page":"105","article-title":"Elevated plasma factor VIII levels in patients with venous thrombosisconstitutional risk factor or secondary epiphenomenon Thromb Res.","volume":"129","author":"Ryan","year":"2012","journal-title":""},{"key":"R52-1-20210226","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/01.ATV.21.2.289","article-title":"Familial clustering of high factor VIII levels in patients with venous thromboembolism.","volume":"21","author":"Schambeck","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R53-1-20210226","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0049-3848(94)90095-7","article-title":"Protein S and HIV infection. The role of anticardiolipin and anti-protein S antibodies.","volume":"73","author":"Sorice","year":"1994","journal-title":"Thromb Res"},{"key":"R54-1-20210226","first-page":"51","article-title":"Early diagnosis of avascular necrosis of the femoral head.","volume":"37","author":"Steinberg","year":"1988","journal-title":"Instr Course Lect"},{"key":"R55-1-20210226","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00003086-198912000-00019","article-title":"A diagnostic algorithm for osteonecrosis of the femoral head.","volume":"249","author":"Stulberg","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"R56-1-20210226","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/art.10835","article-title":"Asymptomatic avascular necrosis in patients with primary antiphospholipid syndrome in the absence of corticosteroid use: a prospective study by magnetic resonance imaging.","volume":"48","author":"Tektonidou","year":"2003","journal-title":"Arthritis Rheum"},{"key":"R57-1-20210226","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.thromres.2011.09.024","article-title":"The acute phase reaction explains only a part of initially elevated factor VIII:C levels: a prospective cohort study in patients with venous thrombosis.","volume":"129","author":"Tichelaar","year":"2012","journal-title":"Thromb Res"},{"key":"R58-1-20210226","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jaut.2009.05.002","article-title":"Management of antiphospholipid syndrome.","volume":"33","author":"Tuthill","year":"2009","journal-title":"J Autoimmun"},{"key":"R59-1-20210226","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1055\/s-0038-1657602","article-title":"The Leiden Thrombophilia Study (LETS).","volume":"78","author":"van der Meer","year":"1997","journal-title":"Thromb Haemost"},{"key":"R60-1-20210226","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0002-9343(94)90108-2","article-title":"Comparison of the primary and secondary antiphospholipid syndrome: a European multicenter study of 114 patients.","volume":"96","author":"Vianna","year":"1994","journal-title":"Am J Med"},{"key":"R61-1-20210226","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/rheumatology\/ker197","article-title":"Effects of an anti-platelet drug on the prevention of steroid-induced osteonecrosis in rabbits.","volume":"51","author":"Yamaguchi","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"R62-1-20210226","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/ard.2003.006197","article-title":"Multiple rib infarcts: a rare form of osteonecrosis in antiphospholipid syndrome.","volume":"63","author":"Yoo","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"R63-1-20210226","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1055\/s-0037-1613138","article-title":"Factor V Leiden and prothrombin gene mutations in femoral head osteonecrosis.","volume":"87","author":"Zalavras","year":"2002","journal-title":"Thromb Haemost"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000000007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T19:46:11Z","timestamp":1646855171000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00005792-201311000-00001"}},"subtitle":["Description of a Series and Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000000007","relation":{},"ISSN":["0025-7974"],"issn-type":[{"value":"0025-7974","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}