{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:46:45Z","timestamp":1768826805785,"version":"3.49.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1097\/md.0000000000012136","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T01:02:36Z","timestamp":1535677356000},"page":"e12136","source":"Crossref","is-referenced-by-count":5,"title":["MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population"],"prefix":"10.1097","volume":"97","author":[{"given":"Chenyang","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guimei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianbo","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-83-20210309","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJMc1609622","article-title":"Ankylosing spondylitis and axial spondyloarthritis","volume":"375","author":"Campochiaro","year":"2016","journal-title":"N Engl J Med"},{"key":"R2-83-20210309","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1186\/ar2368","article-title":"Rheumatic diseases in China","volume":"10","author":"Zeng","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"R3-83-20210309","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/MAJ.0b013e318294457f","article-title":"The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States","volume":"345","author":"Reveille","year":"2013","journal-title":"Am J Med Sci"},{"key":"R4-83-20210309","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.0105-2896.2009.00852.x","article-title":"Genetics and genomics of ankylosing spondylitis","volume":"233","author":"Thomas","year":"2010","journal-title":"Immunol Rev"},{"key":"R5-83-20210309","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11882-014-0489-6","article-title":"Update on ankylosing spondylitis: current concepts in pathogenesis","volume":"15","author":"Smith","year":"2015","journal-title":"Curr Allergy Asthma Rep"},{"key":"R6-83-20210309","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/art.1780401015","article-title":"Susceptibility to ankylosing spondylitis in twins the role of genes, HLA, and the environment","volume":"40","author":"Brown","year":"1997","journal-title":"Arthritis Rheum"},{"key":"R7-83-20210309","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng.2667","article-title":"Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci","volume":"45","author":"Cortes","year":"2013","journal-title":"Nat Genet"},{"key":"R8-83-20210309","doi-asserted-by":"crossref","first-page":"9560","DOI":"10.1073\/pnas.1017854108","article-title":"Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses","volume":"108","author":"Sarin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R9-83-20210309","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Consortium","year":"2011","journal-title":"Nat Genet"},{"key":"R10-83-20210309","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13075-017-1417-7","article-title":"Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study","volume":"19","author":"Jadon","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"R11-83-20210309","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc Res"},{"key":"R12-83-20210309","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/bs.pmbts.2017.03.003","article-title":"Matrix Metalloproteinases and Synovial Joint Pathology","volume":"148","author":"Malemud","year":"2017","journal-title":"Prog Mol Biol Transl Sci"},{"key":"R13-83-20210309","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.bor.0000231904.04548.09","article-title":"Matrix metalloproteinase expression in the spondyloarthropathies","volume":"18","author":"Zhu","year":"2006","journal-title":"Curr Opin Rheumatol"},{"key":"R14-83-20210309","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/978-1-4419-0298-6_9","article-title":"Biomarkers in spondyloarthropathies","volume":"649","author":"Chen","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"R15-83-20210309","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/bj3040347","article-title":"Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan","volume":"304","author":"Fosang","year":"1994","journal-title":"Biochem J"},{"key":"R16-83-20210309","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1158\/0008-5472.CAN-07-5154","article-title":"Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion","volume":"68","author":"Guti\u00e9rrezfern\u00e1ndez","year":"2008","journal-title":"Cancer Res"},{"key":"R17-83-20210309","doi-asserted-by":"crossref","first-page":"21561","DOI":"10.18632\/oncotarget.15371","article-title":"MMP8 polymorphism is associated with susceptibility to osteonecrosis of the femoral head in a Chinese Han population","volume":"8","author":"An","year":"2017","journal-title":"Oncotarget"},{"key":"R18-83-20210309","doi-asserted-by":"crossref","first-page":"R224","DOI":"10.1186\/ar3211","article-title":"Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K\/BxN serum-transfer arthritis model","volume":"12","author":"Garc\u00eda","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"R19-83-20210309","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1186\/ar3857","article-title":"Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis","volume":"14","author":"Mattey","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"R20-83-20210309","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J Biol Chem"},{"key":"R21-83-20210309","doi-asserted-by":"crossref","first-page":"e5407","DOI":"10.1097\/MD.0000000000005407","article-title":"Single-nucleotide polymorphisms of MMP2 in MMP\/TIMP pathways associated with the risk of alcohol-induced osteonecrosis of the femoral head in Chinese males: a case\u2013control study","volume":"95","author":"Yu","year":"2016","journal-title":"Medicine"},{"key":"R22-83-20210309","doi-asserted-by":"crossref","first-page":"304","DOI":"10.15761\/IMM.1000158","article-title":"Blockade of recombinant human IL-6 by tocilizumab suppresses matrix metalloproteinase-9 production in the C28\/I2 immortalized human chondrocyte cell line","volume":"2","author":"Meszaros","year":"2015","journal-title":"Integr Mol Med"},{"key":"R23-83-20210309","doi-asserted-by":"crossref","first-page":"R113","DOI":"10.1186\/ar2772","article-title":"Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-Oncostatin M and response to biologic therapies","volume":"11","author":"Moran","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"R24-83-20210309","doi-asserted-by":"crossref","first-page":"70310","DOI":"10.18632\/oncotarget.20319","article-title":"IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a southwest Chinese population","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"R25-83-20210309","first-page":"1","article-title":"ERAP1 and ERAP2 gene variations influence the risk of psoriatic arthritis in romanian population","volume":"64","author":"Popa","year":"2017","journal-title":"Arch Immunol Ther Exp"},{"key":"R26-83-20210309","doi-asserted-by":"crossref","first-page":"e4794","DOI":"10.1097\/MD.0000000000004794","article-title":"Association between genetic polymorphisms of MMP8 and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China","volume":"95","author":"Du","year":"2016","journal-title":"Medicine"},{"key":"R27-83-20210309","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s10753-013-9758-0","article-title":"MMP-8 genotypes influence the inflammatory response in human endotoxemia","volume":"37","author":"Rella","year":"2014","journal-title":"Inflammation"},{"key":"R28-83-20210309","doi-asserted-by":"crossref","first-page":"25177","DOI":"10.18632\/oncotarget.15587","article-title":"MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"R30-83-20210309","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"R31-83-20210309","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.cr.7290272","article-title":"SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci","volume":"15","author":"Shi","year":"2005","journal-title":"Cell Res"},{"key":"R32-83-20210309","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s10067-015-2949-3","article-title":"Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis","volume":"34","author":"Reveille","year":"2015","journal-title":"Clin Rheumatol"},{"key":"R33-83-20210309","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1002\/art.22589","article-title":"Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis","volume":"56","author":"Maksymowych","year":"2007","journal-title":"Arthritis Rheum"},{"key":"R34-83-20210309","first-page":"22","article-title":"MMP1 polymorphisms are associated with severity of radiographic measures of ankylosing spondylitis","volume":"41","author":"Cortes","year":"2011","journal-title":"Int Med J"},{"key":"R35-83-20210309","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1007\/s11033-013-2743-8","article-title":"MMP - 2, TNF - and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis","volume":"40","author":"Sun","year":"2013","journal-title":"Mol Biol Rep"},{"key":"R36-83-20210309","doi-asserted-by":"crossref","first-page":"17068","DOI":"10.4238\/2015.December.16.7","article-title":"Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis","volume":"14","author":"Gao","year":"2015","journal-title":"Genet Mol Res"},{"key":"R37-83-20210309","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/ijms18040697","article-title":"Role and function of A2A and A3 adenosine receptors in patients with ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis","volume":"18","author":"Ravani","year":"2017","journal-title":"Int J Mol Sci"},{"key":"R38-83-20210309","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1007\/s11033-013-2743-8","article-title":"MMP-2, TNF-( and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis","volume":"40","author":"Sun","year":"2013","journal-title":"Mol Biol Rep"},{"key":"R39-83-20210309","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/alr.20059","article-title":"Altered expression of tissue remodeling genes in a mouse model of acute allergic rhinitis","volume":"1","author":"Sautter","year":"2011","journal-title":"Int Forum Allergy Rhinol"},{"key":"R40-83-20210309","doi-asserted-by":"crossref","first-page":"16282","DOI":"10.1074\/jbc.M113.464230","article-title":"Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells*","volume":"288","author":"Thirkettle","year":"2013","journal-title":"J Biol Chem"},{"key":"R42-83-20210309","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3899\/jrheum.090074","article-title":"Anakinra for rheumatoid arthritis: a systematic review","volume":"36","author":"Mertens","year":"2009","journal-title":"J Rheumatol"},{"key":"R43-83-20210309","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1177\/0300060517708693","article-title":"Association of adipokines, interleukin-6, and tumor necrosis factor-( concentrations with clinical characteristics and presence of spinal syndesmophytes in patients with ankylosing spondylitis: a cross-sectional study","volume":"45","author":"Gonzalez-Lopez","year":"2017","journal-title":"J Int Med Res"},{"key":"R44-83-20210309","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJMc1609622","article-title":"Ankylosing spondylitis and axial spondyloarthritis","volume":"375","author":"Taurog","year":"2016","journal-title":"N Engl J Med"},{"key":"R45-83-20210309","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/annrheumdis-2017-211544","article-title":"TNF blockers inhibit spinal radiographic progression in ankylosing spondylitis by reducing disease activity: results from the Swiss Clinical Quality Management cohort","volume":"77","author":"Molnar","year":"2018","journal-title":"Ann Rheum Dis"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000012136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T03:25:03Z","timestamp":1620962703000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00005792-201808310-00083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":43,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000012136","relation":{},"ISSN":["0025-7974"],"issn-type":[{"value":"0025-7974","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}