{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:01:10Z","timestamp":1775649670632,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"44","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale:<\/jats:title><jats:p>Congenital factor VII (FVII) deficiency is a rare coagulopathy. There are little clinical data for congenital FVII deficiency and no evidence-based medicine guidelines for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient concerns:<\/jats:title><jats:p>A 48-year-old woman with gallbladder stones suffered from intermittent abdominal pain for 2 months that was accompanied by an abnormally prolonged prothrombin time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnoses:<\/jats:title><jats:p>The woman was diagnosed as having cholecystolithiasis with cholecystitis and congenital FVII deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention:<\/jats:title><jats:p>Preoperative evaluation confirmed the necessity of recombinant activated factor VII (rFVIIa) replacement therapy. We monitored the plasma factor VII activity (FVII:C) and coagulation function, determined the half-life of rFVIIa in the patient, and administered personalized rFVIIa replacement therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes:<\/jats:title><jats:p>Laparoscopic cholecystectomy was performed successfully, and the patient recovered well without any complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lessons:<\/jats:title><jats:p>The clinical manifestations and severity of bleeding in patients with congenital FVII deficiency can vary widely. The history of massive bleeding and plasma FVII:C are the decisive factors when implementing a replacement therapy. The actual half-life of rFVIIa can be determined from intensive monitoring results of plasma FVII:C at the beginning of replacement therapy, which could further guide the personalization of rFVIIa replacement therapy.<\/jats:p><\/jats:sec>","DOI":"10.1097\/md.0000000000012776","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T23:41:29Z","timestamp":1541029289000},"page":"e12776","source":"Crossref","is-referenced-by-count":3,"title":["A new perspective on perioperative coagulation management in a patient with congenital factor VII deficiency"],"prefix":"10.1097","volume":"97","author":[{"given":"Yongliang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of General Surgery, China-Japan Friendship Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, China-Japan Friendship Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230914","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/s-0029-1225762","article-title":"Factor VII deficiency","volume":"35","author":"Mariani","year":"2009","journal-title":"Semin Thromb Hemost"},{"issue":"(suppl 4)","key":"R2-20230914","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1365-2516.2012.02841.x","article-title":"Rare bleeding 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